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Gene Review

Con  -  Connectin

Drosophila melanogaster

Synonyms: CG7503, CON, CT1840, Dmel\CG7503, Ubx-t35, ...
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Disease relevance of Con


High impact information on Con

  • This phenotype is suppressed by mutations in FasII and conn, two genes encoding cell adhesion molecules expressed on motor axons, suggesting that beat provides an antiadhesive function. beat encodes a novel secreted protein that is expressed by motoneurons during outgrowth [3].
  • Connectin is expressed on the surface of eight muscles, the motoneurons that innervate them, and several glial cells along the pathways leading to them [4].
  • Engrailed negatively regulates the expression of cell adhesion molecules connectin and neuroglian in embryonic Drosophila nervous system [5].
  • The data suggest that Engrailed is normally a negative regulator of Connectin and neuroglian [5].
  • While a previous study interpreted similar defects as indicating a repulsion role for connectin, we argue that the phenotypes are consistent with connectin's adhesion role [6].

Biological context of Con


Anatomical context of Con


Associations of Con with chemical compounds


Other interactions of Con

  • As VM progenitors merge to form a continuous band running anterior to posterior along the embryo, expression of connectin (con) in 11 metameric patches within the VM reveals VM subdivisions analagous to ectodermal compartments [14].
  • Titin/connectin is a giant muscle protein with a highly modular architecture consisting of multiple repeats of two sequence motifs, named type I and type II [15].

Analytical, diagnostic and therapeutic context of Con


  1. Semaphorin-1a acts in concert with the cell adhesion molecules fasciclin II and connectin to regulate axon fasciculation in Drosophila. Yu, H.H., Huang, A.S., Kolodkin, A.L. Genetics (2000) [Pubmed]
  2. Carbohydrate antigens recognized by anti-horseradish peroxidase antiserum are expressed on mammalian cells. Kurosaka, A., Tsuyuki, Y., Tahara, S. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
  3. The Drosophila beaten path gene encodes a novel secreted protein that regulates defasciculation at motor axon choice points. Fambrough, D., Goodman, C.S. Cell (1996) [Pubmed]
  4. Connectin: a homophilic cell adhesion molecule expressed on a subset of muscles and the motoneurons that innervate them in Drosophila. Nose, A., Mahajan, V.B., Goodman, C.S. Cell (1992) [Pubmed]
  5. Engrailed negatively regulates the expression of cell adhesion molecules connectin and neuroglian in embryonic Drosophila nervous system. Siegler, M.V., Jia, X.X. Neuron (1999) [Pubmed]
  6. Connectin mediates adhesion in Drosophila. Raghavan, S., White, R.A. Neuron (1997) [Pubmed]
  7. Connectin, a target of homeotic gene control in Drosophila. Gould, A.P., White, R.A. Development (1992) [Pubmed]
  8. Functional subdivision of trunk visceral mesoderm parasegments in Drosophila is required for gut and trachea development. Hosono, C., Takaira, K., Matsuda, R., Saigo, K. Development (2003) [Pubmed]
  9. Modification of Drosophila cell surfaces by concanavalin A. Rizki, R.M., Rizki, T.M., Andrews, C.A. Cell Tissue Res. (1977) [Pubmed]
  10. Glycoconjugates of the surface of the spermatozoa of Drosophila melanogaster: a qualitative and quantitative study. Perotti, M.E., Pasini, M.E. J. Exp. Zool. (1995) [Pubmed]
  11. Ectopic expression of connectin reveals a repulsive function during growth cone guidance and synapse formation. Nose, A., Takeichi, M., Goodman, C.S. Neuron (1994) [Pubmed]
  12. The entire cDNA sequences of projectin isoforms of crayfish claw closer and flexor muscles and their localization. Oshino, T., Shimamura, J., Fukuzawa, A., Maruyama, K., Kimura, S. J. Muscle Res. Cell. Motil. (2003) [Pubmed]
  13. Purification and partial characterization of three forms of alpha-glucosidase from the fruit fly Drosophila melanogaster. Tanimura, T., Kitamura, K., Fukuda, T., Kikuchi, T. J. Biochem. (1979) [Pubmed]
  14. Hedgehog and wingless induce metameric pattern in the Drosophila visceral mesoderm. Bilder, D., Scott, M.P. Dev. Biol. (1998) [Pubmed]
  15. 1H and 15N NMR resonance assignments and secondary structure of titin type I domains. Muhle-Goll, C., Nilges, M., Pastore, A. J. Biomol. NMR (1997) [Pubmed]
  16. Purification of a 24 kD parasitism-specific hemolymph protein from pharate pupae of the Caribbean fruit fly, Anastrepha suspensa. Rolle, R.S., Lawrence, P.O. Arch. Insect Biochem. Physiol. (1994) [Pubmed]
  17. Concanavalin A binding sites on the surface of Drosophila melanogaster sperm: a fluorescence and ultrastructural study. Perotti, M.E., Riva, A. J. Ultrastruct. Mol. Struct. Res. (1988) [Pubmed]
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