Disease relevance of Fas2

• Semaphorin-1a acts in concert with the cell adhesion molecules fasciclin II and connectin to regulate axon fasciculation in Drosophila [1].

Psychiatry related information on Fas2

• Drosophila fasciclinII (fasII) mutants perform poorly after olfactory conditioning due to a defect in encoding, stabilizing, or retrieving short-term memories [2].

High impact information on Fas2

• Like several other mutants deficient in odor learning, fasII mutants exhibit a heightened sensitivity to ethanol vapors [2].
• Genetic analysis of growth cone guidance in Drosophila: fasciclin II functions as a neuronal recognition molecule [3].
• This was associated with a significant increase in the postsynaptic DGluR-IIA protein levels and a reduction in the junctional expression of the cell-adhesion molecule Fasciclin II [4].
• Some new boutons exhibit a lower level of Fasciclin II, suggesting that the levels of this synaptic cell adhesion molecule vary locally during synaptic growth [5].
• DLG can directly mediate a biochemical complex and a macroscopic cluster of FASII and Shaker K+ channels in heterologous cells [6].

Biological context of Fas2

• Synaptic clustering of the cell adhesion molecule fasciclin II by discs-large and its role in the regulation of presynaptic structure [6].
• Interestingly, green fluorescent protein reporter gene expression in adult MB lobes was predominantly observed in the alpha and beta lobes with a core-deficient pattern, but not in the alpha' and beta' lobes, similar to Fasciclin II immunoreactivity [7].
• Here we show complementary fasII loss-of-function and gain-of-function phenotypes [8].
• We used the enhancer detection/GAL4 system in Drosophila to direct increased levels of Fasciclin II (Fas II) expression on motoneuron growth cones and axons and to direct ectopic Fas II expression on other cells they encounter [9].
• Mutations in the Abelson tyrosine kinase gene show dominant interactions with fasII mutations, suggesting that Abl and Fas II function in a signaling pathway that controls proneural gene expression [10].

Anatomical context of Fas2

• A Fasciclin 2 morphogenetic switch organizes epithelial cell cluster polarity and motility [11].
• Embryonic and larval development of the Drosophila mushroom bodies: concentric layer subdivisions and the role of fasciclin II [12].
• In addition, the fasII and nac mutants displayed ectopic sensory neurons in the wing [13].
• Taken together, phenotypic analysis, genetic interactions, expression studies and rescue experiments suggest that, in normal development, secretion of Beaten path by cells of the optic lobes allows the Fasciclin II-expressing larval visual organ cells to detach from the optic lobes as a cohesive cell cluster [14].
• Here, we used the Drosophila larval neuromuscular junction to investigate the pathways activated by Fasciclin II (FasII), a transmembrane CAM of the Ig superfamily, during synapse remodeling [15].

Regulatory relationships of Fas2

• No significant genetic interactions were detected with the Notch, Wingless, Hedgehog or Dpp pathways, nor did Fas2 inhibit the FGF receptor or Torso, indicating specificity in the inhibitory role of Fas2 in EGFR signalling [16].

Other interactions of Fas2

• Regulatory betaPS integrin mutations increase the expression and synaptic localization of FAS2 [17].
• Recent work has shown that DLG and FAS2 function together to modulate activity-dependent synaptic development and that this role is regulated by activation of CaMKII [17].
• Drosophila amphiphysin functions during synaptic Fasciclin II membrane cycling [18].
• We observe that the cell adhesion molecule Fasciclin II and the secreted anti-adhesion molecule Beaten path have additional critical roles in the development of at least one set of sensory organs, the larval visual organs [14].
• Neuroglian and FasciclinII can promote neurite outgrowth via the FGF receptor Heartless [19].

Analytical, diagnostic and therapeutic context of Fas2

• Genetic dissection of structural and functional components of synaptic plasticity. II. Fasciclin II controls presynaptic structural plasticity [20].
• The repressive effects of the chimeric protein on fasII gene expression were tested by western-blot analysis and in brain sections of adult Drosophila [21].

References