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Gene Review

Fas2  -  Fasciclin 2

Drosophila melanogaster

Synonyms: 1D4, Ab 1D4, CG3665, CT12301, Dmel\CG3665, ...
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Disease relevance of Fas2


Psychiatry related information on Fas2


High impact information on Fas2

  • Like several other mutants deficient in odor learning, fasII mutants exhibit a heightened sensitivity to ethanol vapors [2].
  • Genetic analysis of growth cone guidance in Drosophila: fasciclin II functions as a neuronal recognition molecule [3].
  • This was associated with a significant increase in the postsynaptic DGluR-IIA protein levels and a reduction in the junctional expression of the cell-adhesion molecule Fasciclin II [4].
  • Some new boutons exhibit a lower level of Fasciclin II, suggesting that the levels of this synaptic cell adhesion molecule vary locally during synaptic growth [5].
  • DLG can directly mediate a biochemical complex and a macroscopic cluster of FASII and Shaker K+ channels in heterologous cells [6].

Biological context of Fas2

  • Synaptic clustering of the cell adhesion molecule fasciclin II by discs-large and its role in the regulation of presynaptic structure [6].
  • Interestingly, green fluorescent protein reporter gene expression in adult MB lobes was predominantly observed in the alpha and beta lobes with a core-deficient pattern, but not in the alpha' and beta' lobes, similar to Fasciclin II immunoreactivity [7].
  • Here we show complementary fasII loss-of-function and gain-of-function phenotypes [8].
  • We used the enhancer detection/GAL4 system in Drosophila to direct increased levels of Fasciclin II (Fas II) expression on motoneuron growth cones and axons and to direct ectopic Fas II expression on other cells they encounter [9].
  • Mutations in the Abelson tyrosine kinase gene show dominant interactions with fasII mutations, suggesting that Abl and Fas II function in a signaling pathway that controls proneural gene expression [10].

Anatomical context of Fas2


Regulatory relationships of Fas2

  • No significant genetic interactions were detected with the Notch, Wingless, Hedgehog or Dpp pathways, nor did Fas2 inhibit the FGF receptor or Torso, indicating specificity in the inhibitory role of Fas2 in EGFR signalling [16].

Other interactions of Fas2


Analytical, diagnostic and therapeutic context of Fas2


  1. Semaphorin-1a acts in concert with the cell adhesion molecules fasciclin II and connectin to regulate axon fasciculation in Drosophila. Yu, H.H., Huang, A.S., Kolodkin, A.L. Genetics (2000) [Pubmed]
  2. Drosophila fasciclinII is required for the formation of odor memories and for normal sensitivity to alcohol. Cheng, Y., Endo, K., Wu, K., Rodan, A.R., Heberlein, U., Davis, R.L. Cell (2001) [Pubmed]
  3. Genetic analysis of growth cone guidance in Drosophila: fasciclin II functions as a neuronal recognition molecule. Grenningloh, G., Rehm, E.J., Goodman, C.S. Cell (1991) [Pubmed]
  4. Postsynaptic translation affects the efficacy and morphology of neuromuscular junctions. Sigrist, S.J., Thiel, P.R., Reiff, D.F., Lachance, P.E., Lasko, P., Schuster, C.M. Nature (2000) [Pubmed]
  5. Watching a synapse grow: noninvasive confocal imaging of synaptic growth in Drosophila. Zito, K., Parnas, D., Fetter, R.D., Isacoff, E.Y., Goodman, C.S. Neuron (1999) [Pubmed]
  6. Synaptic clustering of the cell adhesion molecule fasciclin II by discs-large and its role in the regulation of presynaptic structure. Thomas, U., Kim, E., Kuhlendahl, S., Koh, Y.H., Gundelfinger, E.D., Sheng, M., Garner, C.C., Budnik, V. Neuron (1997) [Pubmed]
  7. Characterization of the dCaMKII-GAL4 driver line whose expression is controlled by the Drosophila Ca2+/calmodulin-dependent protein kinase II promoter. Takamatsu, Y., Nakagoshi, H., Rachidi, M., Lopes, C., Nishida, Y., Ohsako, S. Cell Tissue Res. (2002) [Pubmed]
  8. Genetic analysis of Fasciclin II in Drosophila: defasciculation, refasciculation, and altered fasciculation. Lin, D.M., Fetter, R.D., Kopczynski, C., Grenningloh, G., Goodman, C.S. Neuron (1994) [Pubmed]
  9. Ectopic and increased expression of Fasciclin II alters motoneuron growth cone guidance. Lin, D.M., Goodman, C.S. Neuron (1994) [Pubmed]
  10. Fasciclin II controls proneural gene expression in Drosophila. García-Alonso, L., VanBerkum, M.F., Grenningloh, G., Schuster, C., Goodman, C.S. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  11. A Fasciclin 2 morphogenetic switch organizes epithelial cell cluster polarity and motility. Szafranski, P., Goode, S. Development (2004) [Pubmed]
  12. Embryonic and larval development of the Drosophila mushroom bodies: concentric layer subdivisions and the role of fasciclin II. Kurusu, M., Awasaki, T., Masuda-Nakagawa, L.M., Kawauchi, H., Ito, K., Furukubo-Tokunaga, K. Development (2002) [Pubmed]
  13. Development of Drosophila wing sensory neurons in mutants with missing or modified cell surface molecules. Whitlock, K.E. Development (1993) [Pubmed]
  14. Fasciclin II and Beaten path modulate intercellular adhesion in Drosophila larval visual organ development. Holmes, A.L., Heilig, J.S. Development (1999) [Pubmed]
  15. Fasciclin II signals new synapse formation through amyloid precursor protein and the scaffolding protein dX11/Mint. Ashley, J., Packard, M., Ataman, B., Budnik, V. J. Neurosci. (2005) [Pubmed]
  16. Fasciclin 2, the Drosophila orthologue of neural cell-adhesion molecule, inhibits EGF receptor signalling. Mao, Y., Freeman, M. Development (2009) [Pubmed]
  17. Integrins regulate DLG/FAS2 via a CaM kinase II-dependent pathway to mediate synapse elaboration and stabilization during postembryonic development. Beumer, K., Matthies, H.J., Bradshaw, A., Broadie, K. Development (2002) [Pubmed]
  18. Drosophila amphiphysin functions during synaptic Fasciclin II membrane cycling. Mathew, D., Popescu, A., Budnik, V. J. Neurosci. (2003) [Pubmed]
  19. Neuroglian and FasciclinII can promote neurite outgrowth via the FGF receptor Heartless. Forni, J.J., Romani, S., Doherty, P., Tear, G. Mol. Cell. Neurosci. (2004) [Pubmed]
  20. Genetic dissection of structural and functional components of synaptic plasticity. II. Fasciclin II controls presynaptic structural plasticity. Schuster, C.M., Davis, G.W., Fetter, R.D., Goodman, C.S. Neuron (1996) [Pubmed]
  21. Conditional UAS-targeted repression in Drosophila. Pascual, A., Huang, K.L., Preat, T. Nucleic Acids Res. (2005) [Pubmed]
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