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Gene Review

actb1  -  actin, beta 1

Danio rerio

Synonyms: ACTB, B-ACTZF, SO:0000704, actba, bact, ...
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Disease relevance of bactin1

  • In order to fully capture the dynamic processes of germ cells' proliferation and juvenile hermaphroditism in zebrafish, we established transgenic lines TG(beta-actin:EGFP), harboring an enhanced green fluorescent protein (EGFP) gene driven by a medaka beta-actin promoter [1].
  • These EGFP gene cassettes were flanked by inverted terminal repeats (ITRs) from adeno-associated virus (AAV) and driven by zebrafish alpha-actin (palpha-actin-EGFP-ITR) or medaka beta-actin promoters (pbeta-actin-EGFP-ITR) [2].
  • Of the GFP-positive embryos, 34.6% (81/234), 10% (10/60), and 18% (38/212) showed homogenous GFP-expression for the derivative constructs of the cytomegalovirus, alpha-actin, and beta-actin promoters, respectively [3].

High impact information on bactin1


Biological context of bactin1

  • For the purpose of studying the factors that cause wide variation in transient transgene expression in individual fish, a lacZ reporter gene linked to a carp beta-actin regulatory sequence was introduced into zebrafish embryos [6].

Anatomical context of bactin1


Associations of bactin1 with chemical compounds

  • The three most expressed transcripts were a rhamnose-binding lectin, beta-actin 2, and a transcribed locus similar to the H2B histone family [8].

Other interactions of bactin1


Analytical, diagnostic and therapeutic context of bactin1

  • We have cloned a new beta-actin gene from the teleost zebrafish (Danio rerio), a well-established model for developmental studies, and analysed its expression by Northern blot and in situ hybridization studies [10].
  • Using a semi-quantitative RT-PCR with beta-actin as the internal control, we demonstrated that hCG significantly stimulated mRNA expression of both activin betaA and ActRIIA receptor in the cultured follicle cells in a time- and dose-dependent manner [11].


  1. Transgenic zebrafish with fluorescent germ cell: a useful tool to visualize germ cell proliferation and juvenile hermaphroditism in vivo. Hsiao, C.D., Tsai, H.J. Dev. Biol. (2003) [Pubmed]
  2. Enhanced expression and stable transmission of transgenes flanked by inverted terminal repeats from adeno-associated virus in zebrafish. Hsiao, C.D., Hsieh, F.J., Tsai, H.J. Dev. Dyn. (2001) [Pubmed]
  3. Uniform GFP-expression in transgenic medaka (Oryzias latipes) at the F0 generation. Chou, C.Y., Horng, L.S., Tsai, H.J. Transgenic Res. (2001) [Pubmed]
  4. Regulation of expression of transgenes in developing fish. Moav, B., Liu, Z., Caldovic, L.D., Gross, M.L., Faras, A.J., Hackett, P.B. Transgenic Res. (1993) [Pubmed]
  5. Vitellogenin 1 mRNA as an early molecular biomarker for endocrine disruption in developing zebrafish (Danio rerio). Muncke, J., Eggen, R.I. Environ. Toxicol. Chem. (2006) [Pubmed]
  6. High transgene activity in the yolk syncytial layer affects quantitative transient expression assays in zebrafish Danio rerio) embryos. Williams, D.W., Müller, F., Lavender, F.L., Orbán, L., Maclean, N. Transgenic Res. (1996) [Pubmed]
  7. Changes in gravitational force affect gene expression in developing organ systems at different developmental times. Shimada, N., Sokunbi, G., Moorman, S.J. BMC Dev. Biol. (2005) [Pubmed]
  8. Molecular phenotype of zebrafish ovarian follicle by serial analysis of gene expression and proteomic profiling, and comparison with the transcriptomes of other animals. Knoll-Gellida, A., André, M., Gattegno, T., Forgue, J., Admon, A., Babin, P.J. BMC Genomics (2006) [Pubmed]
  9. Differential regulation of spontaneous and heat-induced HSP 70 expression in developing zebrafish (Danio rerio). Yeh, F.L., Hsu, T. J. Exp. Zool. (2002) [Pubmed]
  10. Differential brain expression of a new beta-actin gene from zebrafish (Danio rerio). Barrallo, A., González-Sarmiento, R., García-Isidoro, M., Cidad, P., Porteros, A., Rodríguez, R.E. Eur. J. Neurosci. (1999) [Pubmed]
  11. Gonadotropin regulation of activin betaA and activin type IIA receptor expression in the ovarian follicle cells of the zebrafish, Danio rerio. Pang, Y., Ge, W. Mol. Cell. Endocrinol. (2002) [Pubmed]
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