Gene Review:
MLLT3 - myeloid/lymphoid or mixed-lineage leukemia...
Homo sapiens
Synonyms:
AF-9, AF9, ALL1-fused gene from chromosome 9 protein, Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein, Protein AF-9, ...
Strissel,
Strick,
Tomek,
Roe,
Rowley,
Zeleznik-Le,
Hemenway,
de Erkenez,
Gould,
Pession,
Martino,
Tonelli,
Beltramini,
Locatelli,
Biserni,
Franzoni,
Freccero,
Montemurro,
Pattacini,
Paolucci,
Martin,
Bass,
Gilbert,
Pericak-Vance,
Hauser,
- MLLT3 gene on 9p22 involved in t(9;11) leukemia encodes a serine/proline rich protein homologous to MLLT1 on 19p13. Iida, S., Seto, M., Yamamoto, K., Komatsu, H., Tojo, A., Asano, S., Kamada, N., Ariyoshi, Y., Takahashi, T., Ueda, R. Oncogene (1993)
- The MLLT3 gene maps between D9S156 and D9S171 and contains an unstable polymorphic trinucleotide repeat. Walker, G.J., Walters, M.K., Palmer, J.M., Hayward, N.K. Genomics (1994)
- The oncogenic capacity of HRX-ENL requires the transcriptional transactivation activity of ENL and the DNA binding motifs of HRX. Slany, R.K., Lavau, C., Cleary, M.L. Mol. Cell. Biol. (1998)
- A murine Mll-AF4 knock-in model results in lymphoid and myeloid deregulation and hematologic malignancy. Chen, W., Li, Q., Hudson, W.A., Kumar, A., Kirchhof, N., Kersey, J.H. Blood (2006)
- The polycomb protein MPc3 interacts with AF9, an MLL fusion partner in t(9;11)(p22;q23) acute leukemias. Hemenway, C.S., de Erkenez, A.C., Gould, G.C. Oncogene (2001)
- The mll-AF9 gene fusion in mice controls myeloproliferation and specifies acute myeloid leukaemogenesis. Dobson, C.L., Warren, A.J., Pannell, R., Forster, A., Lavenir, I., Corral, J., Smith, A.J., Rabbitts, T.H. EMBO J. (1999)
- The amino terminus of the mixed lineage leukemia protein (MLL) promotes cell cycle arrest and monocytic differentiation. Caslini, C., Shilatifard, A., Yang, L., Hess, J.L. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Domains with transcriptional regulatory activity within the ALL1 and AF4 proteins involved in acute leukemia. Prasad, R., Yano, T., Sorio, C., Nakamura, T., Rallapalli, R., Gu, Y., Leshkowitz, D., Croce, C.M., Canaani, E. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Prophylactic amantadine dose and plasma concentration-effect relationships in healthy adults. Aoki, F.Y., Stiver, H.G., Sitar, D.S., Boudreault, A., Ogilvie, R.I. Clin. Pharmacol. Ther. (1985)
- Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs. Nakamura, T., Alder, H., Gu, Y., Prasad, R., Canaani, O., Kamada, N., Gale, R.P., Lange, B., Crist, W.M., Nowell, P.C. Proc. Natl. Acad. Sci. U.S.A. (1993)
- Prenatal and postnatal myeloid cells demonstrate stepwise progression in the pathogenesis of MLL fusion gene leukemia. Johnson, J.J., Chen, W., Hudson, W., Yao, Q., Taylor, M., Rabbitts, T.H., Kersey, J.H. Blood (2003)
- MLL-AF9 oncogene expression affects cell growth but not terminal differentiation and is downregulated during monocyte-macrophage maturation in AML-M5 THP-1 cells. Pession, A., Martino, V., Tonelli, R., Beltramini, C., Locatelli, F., Biserni, G., Franzoni, M., Freccero, F., Montemurro, L., Pattacini, L., Paolucci, G. Oncogene (2003)
- Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9. Krivtsov, A.V., Twomey, D., Feng, Z., Stubbs, M.C., Wang, Y., Faber, J., Levine, J.E., Wang, J., Hahn, W.C., Gilliland, D.G., Golub, T.R., Armstrong, S.A. Nature (2006)
- Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia. Somervaille, T.C., Cleary, M.L. Cancer Cell (2006)
- The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3. García-Cuéllar, M.P., Zilles, O., Schreiner, S.A., Birke, M., Winkler, T.H., Slany, R.K. Oncogene (2001)
- Targeted down-regulation of MLL-AF9 with antisense oligodeoxyribonucleotide reduces the expression of the HOXA7 and -A10 genes and induces apoptosis in a human leukemia cell line, THP-1. Kawagoe, H., Kawagoe, R., Sano, K. Leukemia (2001)
- DNA structural properties of AF9 are similar to MLL and could act as recombination hot spots resulting in MLL/AF9 translocations and leukemogenesis. Strissel, P.L., Strick, R., Tomek, R.J., Roe, B.A., Rowley, J.D., Zeleznik-Le, N.J. Hum. Mol. Genet. (2000)
- Partial duplication of the MLL oncogene in patients with aggressive acute myeloid leukemia. Sambani, C., La Starza, R., Roumier, C., Crescenzi, B., Stavropoulou, C., Katsarou, O., Karafoulidou, A., Dhalle, J.H., Lai, J.L., Preudhomme, C., Martelli, M.F., Mecucci, C. Haematologica (2004)
- Genotype-based association test for general pedigrees: the genotype-PDT. Martin, E.R., Bass, M.P., Gilbert, J.R., Pericak-Vance, M.A., Hauser, E.R. Genet. Epidemiol. (2003)
- Monitoring of minimal residual leukemia in patients with MLL-AF9 positive acute myeloid leukemia by RT-PCR. Mitterbauer, G., Zimmer, C., Fonatsch, C., Haas, O., Thalhammer-Scherrer, R., Schwarzinger, I., Kalhs, P., Jaeger, U., Lechner, K., Mannhalter, C. Leukemia (1999)