Gene Review:
MLLT1 - myeloid/lymphoid or mixed-lineage leukemia...
Homo sapiens
Synonyms:
ENL, LTG19, Protein ENL, YEATS domain-containing protein 1, YEATS1
- The leukemia-associated gene Mllt1/ENL: characterization of a murine homolog and demonstration of an essential role in embryonic development. Doty, R.T., Vanasse, G.J., Disteche, C.M., Willerford, D.M. Blood Cells Mol. Dis. (2002)
- The oncogenic capacity of HRX-ENL requires the transcriptional transactivation activity of ENL and the DNA binding motifs of HRX. Slany, R.K., Lavau, C., Cleary, M.L. Mol. Cell. Biol. (1998)
- Molecular analysis of t(11;19) breakpoints in childhood acute leukemias. Rubnitz, J.E., Behm, F.G., Curcio-Brint, A.M., Pinheiro, R.P., Carroll, A.J., Raimondi, S.C., Shurtleff, S.A., Downing, J.R. Blood (1996)
- The mechanism of hematopoietic progenitor cell immortalization by MLL-ENL. Horton, S.J., Williams, O. Cell Cycle (2006)
- Patterns of disease in localized extranodal lymphomas. Gospodarowicz, M.K., Sutcliffe, S.B., Brown, T.C., Chua, T., Bush, R.S. J. Clin. Oncol. (1987)
- Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias. Tkachuk, D.C., Kohler, S., Cleary, M.L. Cell (1992)
- MLL-ENL cooperates with SCF to transform primary avian multipotent cells. Schulte, C.E., von Lindern, M., Steinlein, P., Beug, H., Wiedemann, L.M. EMBO J. (2002)
- Molecular emergence of acute myeloid leukemia during treatment for acute lymphoblastic leukemia. Blanco, J.G., Dervieux, T., Edick, M.J., Mehta, P.K., Rubnitz, J.E., Shurtleff, S., Raimondi, S.C., Behm, F.G., Pui, C.H., Relling, M.V. Proc. Natl. Acad. Sci. U.S.A. (2001)
- Acute leukemias of different lineages have similar MLL gene fusions encoding related chimeric proteins resulting from chromosomal translocation. Corral, J., Forster, A., Thompson, S., Lampert, F., Kaneko, Y., Slater, R., Kroes, W.G., van der Schoot, C.E., Ludwig, W.D., Karpas, A. Proc. Natl. Acad. Sci. U.S.A. (1993)
- IgG antibody subclasses, tumor necrosis factor and IFN-gamma levels in patients with type II lepra reaction on thalidomide treatment. Partida-Sanchez, S., Favila-Castillo, L., Pedraza-Sanchez, S., Gomez-Melgar, M., Saul, A., Estrada-Parra, S., Estrada-Garcia, I. Int. Arch. Allergy Immunol. (1998)
- Effect of one year clofazimine therapy on autonomic functions in lepromatous leprosy with lepra (ENL) reaction. Burte, N.P., Chandorkar, A.G., Muley, M.P., Balsara, J.J., Bulakh, P.M. Leprosy in India. (1983)
- Levamisole in cases of E.N.L. Arora, S.K., Singh, G., Sen, P.C. Indian journal of leprosy. (1985)
- Deep vein thrombosis: a rare complication of thalidomide therapy in recurrent erythema nodosum leprosum. Sharma, N.L., Sharma, V., Shanker, V., Mahajan, V.K., Sarin, S. Int. J. Lepr. Other Mycobact. Dis. (2004)
- Serological study for presence of C-reactive protein, rheumatoid factor, anti streptolysin O in leprosy cases. Bhatia, V.N., Balakrishnan, S., Harikrishnan, S. Leprosy in India. (1983)
- The HRX proto-oncogene product is widely expressed in human tissues and localizes to nuclear structures. Butler, L.H., Slany, R., Cui, X., Cleary, M.L., Mason, D.Y. Blood (1997)
- Two distinct portions of LTG19/ENL at 19p13 are involved in t(11;19) leukemia. Yamamoto, K., Seto, M., Komatsu, H., Iida, S., Akao, Y., Kojima, S., Kodera, Y., Nakazawa, S., Ariyoshi, Y., Takahashi, T. Oncogene (1993)
- The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3. García-Cuéllar, M.P., Zilles, O., Schreiner, S.A., Birke, M., Winkler, T.H., Slany, R.K. Oncogene (2001)
- Complex MLL rearrangement in a patient with T-cell acute lymphoblastic leukemia. Chervinsky, D.S., Sait, S.N., Nowak, N.J., Shows, T.B., Aplan, P.D. Genes Chromosomes Cancer (1995)
- Analysis of Acute Leukemias With MLL/ENL Fusion Transcripts: Identification of Two Novel Breakpoints in ENL. Fu, J.F., Liang, D.C., Shih, L.Y. Am. J. Clin. Pathol. (2007)
- MLLT3 gene on 9p22 involved in t(9;11) leukemia encodes a serine/proline rich protein homologous to MLLT1 on 19p13. Iida, S., Seto, M., Yamamoto, K., Komatsu, H., Tojo, A., Asano, S., Kamada, N., Ariyoshi, Y., Takahashi, T., Ueda, R. Oncogene (1993)
- Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization. Zeisig, B.B., Milne, T., García-Cuéllar, M.P., Schreiner, S., Martin, M.E., Fuchs, U., Borkhardt, A., Chanda, S.K., Walker, J., Soden, R., Hess, J.L., Slany, R.K. Mol. Cell. Biol. (2004)
- Characterization of t(11;19)(q23;p13.3) by fluorescence in situ hybridization analysis in a pediatric patient with therapy-related acute myelogenous leukemia. Cheng, L., Ramesh, K.H., Radel, E., Ratech, H., Wei, D., Cannizzaro, L.A. Cancer Genet. Cytogenet. (2001)
- Oral zinc in recurrent Erythema Nodosum Leprosum reaction. Mathur, N.K., Bumb, R.A., Mangal, H.N. Leprosy in India. (1983)
- The eleven-nineteen-leukemia protein ENL connects nuclear MLL fusion partners with chromatin. Zeisig, D.T., Bittner, C.B., Zeisig, B.B., García-Cuéllar, M.P., Hess, J.L., Slany, R.K. Oncogene (2005)
- Simultaneous localization of MLL, AF4 and ENL genes in interphase nuclei by 3D-FISH: MLL translocation revisited. Gué, M., Sun, J.S., Boudier, T. BMC Cancer (2006)
- A RUNX/AML-binding motif residing in a novel 13-bp DNA palindrome may determine the expression of the proximal promoter of the human uPA gene. Kopf, E., Miskin, R. J. Thromb. Haemost. (2005)
- Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs. Nakamura, T., Alder, H., Gu, Y., Prasad, R., Canaani, O., Kamada, N., Gale, R.P., Lange, B., Crist, W.M., Nowell, P.C. Proc. Natl. Acad. Sci. U.S.A. (1993)
- Prospective randomized comparison of external dacryocystorhinostomy and endonasal laser dacryocystorhinostomy. Hartikainen, J., Grenman, R., Puukka, P., Seppä, H. Ophthalmology (1998)
- Differences in predominant T cell phenotypes and distribution pattern in reactional lesions of tuberculoid and lepromatous leprosy. Narayanan, R.B., Laal, S., Sharma, A.K., Bhutani, L.K., Nath, I. Clin. Exp. Immunol. (1984)