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Gene Review

CASP3  -  caspase 3, apoptosis-related cysteine...

Pan troglodytes

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Disease relevance of CASP3


High impact information on CASP3


Biological context of CASP3

  • Lastly, a pan caspase inhibitor (Z-D-DCB) and 2'-deoxycytidine (dCyd), which is known to prevent dGTP accumulation following PNP inhibition, were able to prevent cell death and all indicators of caspase-3-like activity in MOLT-4 cells co-treated with dGuo and CI-1000 [8].

Anatomical context of CASP3

  • In summary, we provided several lines of evidence for the role of apoptosis and the contribution of caspase-3-like proteases in T-cell death following PNP inhibition [8].

Associations of CASP3 with chemical compounds

  • Anti-PARP revealed the presence of an 85 kD PARP breakdown product while, anti-alpha-spectrin revealed the accumulation a 120 kD breakdown product, both suggestive of CPP32 cleavage (caspase-3; an ICE-like cysteine protease) [8].
  • RESULTS: Cisplatin induced a dose-dependent increase in Caspase-3 activity and 8-fold of increase in apoptosis (p < 0.01) when applied for 24 h at 100 microM [9].

Analytical, diagnostic and therapeutic context of CASP3


  1. Cyclosporine A protects against arachidonic acid toxicity in rat hepatocytes: role of CYP2E1 and mitochondria. Wu, D., Cederbaum, A.I. Hepatology (2002) [Pubmed]
  2. Effects of caspase inhibition on the progression of experimental glomerulonephritis. Yang, B., Johnson, T.S., Haylor, J.L., Wagner, B., Watson, P.F., El Kossi, M.M., Furness, P.N., El Nahas, A.M. Kidney Int. (2003) [Pubmed]
  3. Induction of apoptosis by combined treatment with differentiation-inducing agents and interferon-alpha in human lung cancer cells. Yamamoto-Yamaguchi, Y., Okabe-Kado, J., Kasukabe, T., Honma, Y. Anticancer Res. (2003) [Pubmed]
  4. Radiation induced cytochrome c release causes loss of rat colonic fluid absorption by damage to crypts and pericryptal myofibroblasts. Thiagarajah, J.R., Gourmelon, P., Griffiths, N.M., Lebrun, F., Naftalin, R.J., Pedley, K.C. Gut (2000) [Pubmed]
  5. Mitochondria and calpains mediate caspase-dependent apoptosis induced by doxycycline in HeLa cells. Wu, J., Liu, T., Xie, J., Xin, F., Guo, L. Cell. Mol. Life Sci. (2006) [Pubmed]
  6. Cell-specific caspase expression by different neuronal phenotypes in transient retinal ischemia. Singh, M., Savitz, S.I., Hoque, R., Gupta, G., Roth, S., Rosenbaum, P.S., Rosenbaum, D.M. J. Neurochem. (2001) [Pubmed]
  7. Carbazolequinone induction of caspase-dependent cell death in Src-overexpressing cells. Aouacheria, A., Néel, B., Bouaziz, Z., Dominique, R., Walchshofer, N., Paris, J., Fillion, H., Gillet, G. Biochem. Pharmacol. (2002) [Pubmed]
  8. A purine nucleoside phosphorylase (PNP) inhibitor induces apoptosis via caspase-3-like protease activity in MOLT-4 T cells. Posmantur, R., Wang, K.K., Nath, R., Gilbertsen, R.B. Immunopharmacology (1997) [Pubmed]
  9. Inhibitors directed towards caspase-1 and -3 are less effective than pan caspase inhibition in preventing renal proximal tubular cell apoptosis. Yang, B., El Nahas, A.M., Fisher, M., Wagner, B., Huang, L., Storie, I., Barnett, D., Barratt, J., Smith, A.C., Johnson, T.S. Nephron Exp. Nephrol. (2004) [Pubmed]
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