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MeSH Review

CD8-Positive T-Lymphocytes

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Disease relevance of CD8-Positive T-Lymphocytes

  • The mechanism of suppression by PWM-activated T8+ cells of T4+ cell proliferation, not only to PWM, but also to tetanus toxoid, was pursued by measuring decreased interleukin 2 (IL2) recovery from cultures containing suppressors [1].
  • Interferon-alpha modulates the immune response enhancing B7-1 and B7-2 costimulatory molecules and T8 lymphocytes in chronic myeloid leukemia [2].
  • Immunohistochemical experiments showed that in AIDS lymphomas intratumoral CD8-positive T lymphocytes accumulated and expressed the TIA-1 antigen, a marker of cytotoxic cells [3].
  • OBJECTIVES: We investigated the shifts of T4/T8 lymphocytes from BAL fluid (BALF) and peripheral blood by the clinical grade of pulmonary tuberculosis (TB), which is determined by factors such as extent of pulmonary involvement, fever, and loss of body weight [4].
  • Since in HIV-infected persons, the increased number of HLA-DR+ CD38+T (T8) cells is associated with a fall in CD4-level and with development of AIDS, we are looking for the elimination of these HLA-DR+ targets by our novel technique in two AIDS-simulating (FIV/FeLV and SIV) animal models [5].

Psychiatry related information on CD8-Positive T-Lymphocytes

  • The significance of LCA, T4 and T8 cells in Alzheimer's disease is unknown but may be indicative of a cell mediated immune response in the disease [6].

High impact information on CD8-Positive T-Lymphocytes

  • During the course of investigating the regulation of IL-2-dependent T cell proliferation, we found that the subset of human T cells expressing the T4 surface glycoprotein become refractory to IL-2 growth promotion earlier than T8+ cells [7].
  • Moreover, a detailed comparison of IL-2-R expression by T4+ vs. T8+ cells revealed no differences in the number, affinity, rate of expression, or functional activity of high-affinity IL-2-R expressed by the two subsets [7].
  • Both T4 and T8 lymphocytes were found to make mRNA for TGF-beta upon activation [8].
  • In contrast, the clusters in RA SF cultures have a T4/T8 ratio of less than 1 and a majority of the T8 cells coexpress the Leu 7 marker [9].
  • In this study, we demonstrate that both highly purified T4+ and T8+ lymphocytes can produce substantial amounts of Interleukin 2(IL 2) when stimulated with the combination of concanavalin A (Con A) and phorbol myristate acetate [10].

Chemical compound and disease context of CD8-Positive T-Lymphocytes


Biological context of CD8-Positive T-Lymphocytes


Anatomical context of CD8-Positive T-Lymphocytes

  • Finally, whereas TsGF in the absence of IL-2 could not support the proliferation of T suppressor cells, it did cause T8+ cells to become strongly IL-2 receptor-positive [17].
  • In the majority of sera, cytotoxicity for T4+ cells was greater than that for T8+ cells regardless of cellular activation status [18].
  • By performing reconstitution experiments involving E+, T4+, or T8+ cells derived from either MS patients or controls, and normal allogeneic macrophages or E- cells, we sought to define the cellular basis for this suppressor defect [19].
  • To see if PAGF was a T-dependent polyclonal activator of B cells, T and non-T populations were obtained by SRBC rosettes and negatively selected T4 and T8 cells by complement-mediated lysis of SRBC+(T) cells [20].
  • In this context, the rejection of TSA-IL4 seems to involve a variety of reactive cells and rests on a continuous cross-talk between basophils, mast cells, macrophages, CD8-positive lymphocytes, and granulocyte subsets, mostly neutrophils [21].

Associations of CD8-Positive T-Lymphocytes with chemical compounds

  • Treatment of the same cells with hydroxyurea, an inhibitor of DNA synthesis, failed to induce T4 on T8+ cells [22].
  • Furthermore, T8+ cell-depleted T lymphocyte cultures, incubated for 24 hr with LTB4, showed a significant increase in the proportion of T8+ cells [23].
  • Substantial levels of IL-2 responsiveness were induced in T8+ cells by lectin, Con A, mAb directed against the CD3 Ag, OKT3, Ca2+ ionophore, ionomycin or phorbol ester, PMA [24].
  • Using either approach we found that both T4 and T8 lymphocytes expressed the 1,25-(OH)2D3 receptor protein upon activation [25].
  • The selective activation of T8+ cells by neuraminidase and galactose oxidase is mediated by activated T4+ cells [26].

Gene context of CD8-Positive T-Lymphocytes

  • Moreover, an Mab directed at the CD4 molecule (66.1) inhibited OKT3-induced T4 but not T8 cell proliferation, whereas an Mab directed at the CD8 molecule (OKT8) inhibited T8 but not T4 cell responses [27].
  • Splenic CD8-positive lymphocytes expressed increased levels of IFN-gamma and IL-10 but the latter decreased sharply when diabetes occurred [28].
  • Moreover, addition of mAb to the p55 component of IL2 receptor (anti-Tac) inhibited the generation of suppressor activity from CD45RA+ and CD45RA- T8 cells [29].
  • After exposure to HCV E2 markedly fewer CD8-positive lymphocytes were attracted by RANTES when compared with CD8+ cells that were studied in the absence of HCV E2 [30].
  • Furthermore, IL-1 beta was negatively correlated with the number of T8 lymphocytes [31].

Analytical, diagnostic and therapeutic context of CD8-Positive T-Lymphocytes


  1. Regulatory interactions governing the proliferation of T cell subsets stimulated with pokeweed mitogen. Puck, J.M., Rich, R.R. J. Immunol. (1984) [Pubmed]
  2. Interferon-alpha modulates the immune response enhancing B7-1 and B7-2 costimulatory molecules and T8 lymphocytes in chronic myeloid leukemia. Delfini, C., Centis, F., Tabellini, L., Nicolini, G., Visani, G. Leukemia (2003) [Pubmed]
  3. Intratumoral activation of CD8-positive cytotoxic lymphocytes in acquired immunodeficiency syndrome lymphomas. Devergne, O., Raphael, M., Autran, B., Leger-Ravet, M.B., Coumbaras, J., Crevon, M.C., Galanaud, P., Emilie, D. Hum. Pathol. (1995) [Pubmed]
  4. Shifts of T4/T8 T lymphocytes from BAL fluid and peripheral blood by clinical grade in patients with pulmonary tuberculosis. Tsao, T.C., Chen, C.H., Hong, J.H., Hsieh, M.J., Tsao, K.C., Lee, C.H. Chest (2002) [Pubmed]
  5. Treatment of solid tumors should obligatorily be combined with the in vivo codepletion of tumor-protecting, CD8+/HLA-DR(+)-suppressor T cells by alloreactive donor T cells whose preprogrammed cell death allows a high GvL-effect before GvHD can be established. Results of animal experiments, including more than 6000 mice. Leskovar, P., Bielmeier, J. Pflugers Arch. (1996) [Pubmed]
  6. Presence of T-cytotoxic suppressor and leucocyte common antigen positive cells in Alzheimer's disease brain tissue. Itagaki, S., McGeer, P.L., Akiyama, H. Neurosci. Lett. (1988) [Pubmed]
  7. Regulation of T cell autocrine growth. T4+ cells become refractory to interleukin 2. Gullberg, M., Smith, K.A. J. Exp. Med. (1986) [Pubmed]
  8. Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth. Kehrl, J.H., Wakefield, L.M., Roberts, A.B., Jakowlew, S., Alvarez-Mon, M., Derynck, R., Sporn, M.B., Fauci, A.S. J. Exp. Med. (1986) [Pubmed]
  9. Dendritic cell-lymphocyte clusters that form spontaneously in rheumatoid arthritis synovial effusions differ from clusters formed in human mixed leukocyte reactions. Tsai, V., Zvaifler, N.J. J. Clin. Invest. (1988) [Pubmed]
  10. Human lymphocytes with either the OKT4 or OKT8 phenotype produce interleukin 2 in culture. Luger, T.A., Smolen, J.S., Chused, T.M., Steinberg, A.D., Oppenheim, J.J. J. Clin. Invest. (1982) [Pubmed]
  11. Effects of cyclosporin on T-cell subsets in human immunodeficiency virus disease. Andrieu, J.M., Even, P., Venet, A., Tourani, J.M., Stern, M., Lowenstein, W., Audroin, C., Eme, D., Masson, D., Sors, H. Clin. Immunol. Immunopathol. (1988) [Pubmed]
  12. Immunosuppressive effects of isoprinosine in man: a comparison to chlorambucil effects in multiple sclerosis. Pompidou, A., Rancurel, G., Delsaux, M.C., Meunier, C., Telvi, L., Cour, V., Buge, A. Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc. (1987) [Pubmed]
  13. CSF cells in multiple sclerosis: monoclonal antibody analysis and relationship to peripheral blood T-cell subsets. Hauser, S.L., Reinherz, E.L., Hoban, C.J., Schlossman, S.F., Weiner, H.L. Neurology (1983) [Pubmed]
  14. V3 loop of human immunodeficiency virus type 1 suppresses interleukin 2-induced T cell growth. Sakaida, H., Murakami, T., Kawamata, S., Hattori, T., Uchiyama, T. AIDS Res. Hum. Retroviruses (1997) [Pubmed]
  15. The stimulation of angiotensin-converting enzyme induction in cultured monocytes by T4+ and T8+ lymphocytes. Lauderdale, B., Rohrbach, M.S. Ann. N. Y. Acad. Sci. (1986) [Pubmed]
  16. Intratumoral administration of a 1,2-dimyristyloxypropyl-3- dimethylhydroxyethyl ammonium bromide/dioleoylphosphatidylethanolamine formulation of the human interleukin-2 gene in the treatment of metastatic renal cell carcinoma. Galanis, E., Burch, P.A., Richardson, R.L., Lewis, B., Pitot, H.C., Frytak, S., Spier, C., Akporiaye, E.T., Peethambaram, P.P., Kaur, J.S., Okuno, S.H., Unni, K.K., Rubin, J. Cancer (2004) [Pubmed]
  17. Proliferative signals for suppressor T cells. Helper cells stimulated with pokeweed mitogen in vitro produce a suppressor cell growth factor. Fox, E.J., Cook, R.G., Lewis, D.E., Rich, R.R. J. Clin. Invest. (1986) [Pubmed]
  18. Subset specificity of antilymphocyte antibodies in systemic lupus erythematosus. Preferential reactivity with cells bearing the T4 and autologous erythrocyte receptor phenotypes. Yamada, A., Cohen, P.L., Winfield, J.B. Arthritis Rheum. (1985) [Pubmed]
  19. Activated suppressor cell dysfunction in progressive multiple sclerosis. Antel, J.P., Bania, M.B., Reder, A., Cashman, N. J. Immunol. (1986) [Pubmed]
  20. Pregnancy-associated growth factor. II. A T-dependent polyclonal activator of human adult peripheral blood lymphocytes (PBL). Carlino, J.A., Morse, J.H. J. Immunol. (1985) [Pubmed]
  21. Interaction between endothelial cells and the secreted cytokine drives the fate of an IL4- or an IL5-transduced tumour. Di Carlo, E., Modesti, A., Coletti, A., Colombo, M.P., Giovarelli, M., Forni, G., Diodoro, M.G., Musiani, P. J. Pathol. (1998) [Pubmed]
  22. Effect of an inhibitor of DNA methylation on T cells. I. 5-Azacytidine induces T4 expression on T8+ T cells. Richardson, B., Kahn, L., Lovett, E.J., Hudson, J. J. Immunol. (1986) [Pubmed]
  23. Differential effects of leukotriene B4 on T4+ and T8+ lymphocyte phenotype and immunoregulatory functions. Rola-Pleszczynski, M. J. Immunol. (1985) [Pubmed]
  24. Intracellular activation signal requirements for the induction of IL-2 responsiveness in resting T cell subsets in humans. Tsuchida, T., Sakane, T. J. Immunol. (1988) [Pubmed]
  25. 1 Alpha,25-dihydroxyvitamin D3 receptor distribution and effects in subpopulations of normal human T lymphocytes. Provvedini, D.M., Manolagas, S.C. J. Clin. Endocrinol. Metab. (1989) [Pubmed]
  26. The selective activation of T8+ cells by neuraminidase and galactose oxidase is mediated by activated T4+ cells. Akeson, A.L., Harmony, J.A. Exp. Cell Res. (1987) [Pubmed]
  27. Accessory cell-T cell interactions involved in anti-CD3-induced T4 and T8 cell proliferation: analysis with monoclonal antibodies. Geppert, T.D., Lipsky, P.E. J. Immunol. (1986) [Pubmed]
  28. The expression of cytokine genes in the peritoneal macrophages and splenic CD4- and CD8-positive lymphocytes of the nonobese diabetic mice. Yaacob, N.S., Kaderi, M.A., Norazmi, M.N. J. Clin. Immunol. (2004) [Pubmed]
  29. T8 cell regulation of human B cell responsiveness: regulatory influences of CD45RA+ and CD45RA- T8 cell subsets. Hirohata, S. Cell. Immunol. (1991) [Pubmed]
  30. Binding of HCV E2 to CD81 induces RANTES secretion and internalization of CC chemokine receptor 5. Nattermann, J., Nischalke, H.D., Feldmann, G., Ahlenstiel, G., Sauerbruch, T., Spengler, U. J. Viral Hepat. (2004) [Pubmed]
  31. Direct stimulation of cytokines (IL-1 beta, TNF-alpha, IL-6, IL-2, IFN-gamma and GM-CSF) in whole blood. I. Comparison with isolated PBMC stimulation. De Groote, D., Zangerle, P.F., Gevaert, Y., Fassotte, M.F., Beguin, Y., Noizat-Pirenne, F., Pirenne, J., Gathy, R., Lopez, M., Dehart, I. Cytokine (1992) [Pubmed]
  32. Defective suppressor cell function mediated by T8+ cell lines from patients with progressive multiple sclerosis. Antel, J., Bania, M., Noronha, A., Neely, S. J. Immunol. (1986) [Pubmed]
  33. Subset specificity of antilymhocyte antibodies in systemic lupus erythematosus. II. Preferential reactivity with T4 + cells is associated with relative depletion of autologous T4 + cells. Winfield, J.B., Shaw, M., Yamada, A., Minota, S. Arthritis Rheum. (1987) [Pubmed]
  34. Clinical, hematologic, and immunologic cross-sectional evaluation of individuals exposed to human immunodeficiency virus type-2 (HIV-2). Marlink, R.G., Ricard, D., M'Boup, S., Kanki, P.J., Romet-Lemonne, J.L., N'Doye, I., Diop, K., Simpson, M.A., Greco, F., Chou, M.J. AIDS Res. Hum. Retroviruses (1988) [Pubmed]
  35. Different effects of IL-2 addition or antibody crosslinking on T-cell subset stimulation by CD3 antibodies. Walker, C., Pichler, W.J., Koponen, M., Domzig, W., de Weck, A.L. Cell. Immunol. (1986) [Pubmed]
  36. Activities of granulocyte-macrophage colony-stimulating factor revealed by gene transfer and gene knockout studies. Dranoff, G., Mulligan, R.C. Stem Cells (1994) [Pubmed]
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