The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Slc2a8  -  solute carrier family 2, (facilitated...

Mus musculus

Synonyms: D2Ertd44e, GLUT-8, GLUT8, Glucose transporter type 8, Glucose transporter type X1, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Slc2a8


High impact information on Slc2a8


Biological context of Slc2a8


Anatomical context of Slc2a8


Associations of Slc2a8 with chemical compounds

  • By employing stable transfectants that expressed GLUT8-GFP, the effect of insulin and insulin-like growth factor-I, potassium chloride (depolarized state), and 3% oxygen on translocation of GLUT8 to the plasma membrane of N2A cells was examined immunohistochemically and by subfractionation, followed by Western blot analysis [3].
  • However, when the internalization dileucine motif (L(12,13)) of GLUT8 was mutated to a dialanine motif (A(12,13)), GLUT8 colocalized with GLUT3 in the plasma membrane [3].

Regulatory relationships of Slc2a8

  • Exposure to insulin in the embryos exposed to IGF-1R sense induced translocation of GLUT8 from intracellular compartments to the plasma membrane [8].

Other interactions of Slc2a8

  • This difference in GLUT8 translocation directly correlated with one-third of blastocysts from Stx4a+/- mating having reduced rates of insulin-stimulated glucose uptake and 67% with wild-type rates [1].
  • GLUT8 is a novel IGF-I/insulin-regulated glucose transporter expressed in the mouse blastocyst [1].
  • Blastocysts exposed to IGF-1R antisense, however, failed to demonstrate any change in the intracellular location of GLUT8 with insulin treatment [8].
  • Exogenous expression of GLUT8-green fluorescent protein (GFP) DNA constructs mimicked the endogenous GLUT8 localization to intracellular vesicles and minimally to the Giantin-positive Golgi [3].

Analytical, diagnostic and therapeutic context of Slc2a8


  1. Syntaxin 4 expression affects glucose transporter 8 translocation and embryo survival. Wyman, A.H., Chi, M., Riley, J., Carayannopoulos, M.O., Yang, C., Coker, K.J., Pessin, J.E., Moley, K.H. Mol. Endocrinol. (2003) [Pubmed]
  2. GLUT8 subcellular localization and absence of translocation to the plasma membrane in PC12 cells and hippocampal neurons. Widmer, M., Uldry, M., Thorens, B. Endocrinology (2005) [Pubmed]
  3. Glucose transporter GLUT8 translocation in neurons is not insulin responsive. Shin, B.C., McKnight, R.A., Devaskar, S.U. J. Neurosci. Res. (2004) [Pubmed]
  4. GLUT8 is a glucose transporter responsible for insulin-stimulated glucose uptake in the blastocyst. Carayannopoulos, M.O., Chi, M.M., Cui, Y., Pingsterhaus, J.M., McKnight, R.A., Mueckler, M., Devaskar, S.U., Moley, K.H. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  5. GLUT8 is dispensable for embryonic development but influences hippocampal neurogenesis and heart function. Membrez, M., Hummler, E., Beermann, F., Haefliger, J.A., Savioz, R., Pedrazzini, T., Thorens, B. Mol. Cell. Biol. (2006) [Pubmed]
  6. Regulation of hepatic GLUT8 expression in normal and diabetic models. Gorovits, N., Cui, L., Busik, J.V., Ranalletta, M., Hauguel de-Mouzon, S., Charron, M.J. Endocrinology (2003) [Pubmed]
  7. Localization of the GLUT8 glucose transporter in murine kidney and regulation in vivo in nondiabetic and diabetic conditions. Schiffer, M., Susztak, K., Ranalletta, M., Raff, A.C., Böttinger, E.P., Charron, M.J. Am. J. Physiol. Renal Physiol. (2005) [Pubmed]
  8. Glucose transporter 8 expression and translocation are critical for murine blastocyst survival. Pinto, A.B., Carayannopoulos, M.O., Hoehn, A., Dowd, L., Moley, K.H. Biol. Reprod. (2002) [Pubmed]
  9. Insulin-responsive glucose transporters-GLUT8 and GLUT4 are expressed in the developing mammalian brain. Sankar, R., Thamotharan, S., Shin, D., Moley, K.H., Devaskar, S.U. Brain Res. Mol. Brain Res. (2002) [Pubmed]
  10. Differential expression of glucose transporter GLUT8 during mouse spermatogenesis. Gómez, O., Romero, A., Terrado, J., Mesonero, J.E. Reproduction (2006) [Pubmed]
WikiGenes - Universities