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Gene Review

PDGFC  -  platelet derived growth factor C

Homo sapiens

Synonyms: FALLOTEIN, Fallotein, PDGF-C, Platelet-derived growth factor C, SCDGF, ...
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Disease relevance of PDGFC


High impact information on PDGFC

  • PDGF-C protein was not differentially expressed in OA and RA [5].
  • PDGF-C and PDGF-D were expressed throughout the SM (lining layer, diffuse infiltrates, and stroma) by both synovial fibroblasts and macrophages [5].
  • Platelet-derived growth factor C (PDGF-C) is one of four members in the PDGF family of growth factors, which are known mitogens and survival factors for cells of mesenchymal origin [1].
  • PDGF-C is secreted as a latent dimeric factor (PDGF-CC), which undergoes extracellular removal of the CUB domains to become a PDGF receptor alpha agonist [1].
  • Inhibition of PDGF-B via specific aptamers reduced the injury in anti-Thy 1.1 nephritis but did not affect the glomerular PDGF-C overexpression or the mitogenicity of PDGF-CC in vitro [3].

Chemical compound and disease context of PDGFC


Biological context of PDGFC


Anatomical context of PDGFC

  • In addition, we showed that Calu-6 tumors express significant levels of PDGFC, and that the levels of expression of these two PDGFRalpha ligands correlate strongly with the degree of stromal fibroblast infiltration into the tumor mass [10].
  • CONCLUSION: PDGF-C and PDGF-D are expressed by synovial fibroblasts and macrophages in RA and OA SMs [5].
  • This demonstrates that specific inhibition of PDGF-C signaling in EFT cell lines partially reverts their phenotype [8].
  • It is concluded that PDGF-C is a novel mesangial cell mitogen that is constitutively expressed in the kidney and specifically upregulated in mesangial, visceral epithelial, and interstitial cells after predominant injury to these cells [3].
  • Dominant negative PDGF-C inhibits growth of Ewing family tumor cell lines [8].

Associations of PDGFC with chemical compounds

  • They also suggest that PDGF-C driven signaling may be a possible therapeutic target of more clinically relevant tyrosine kinase inhibitors [8].
  • PDGF-C expressed nuclear localisation in 95% of all tested cell types in culture and in 10% of the thyrocytes from both PTC and non-neoplastic tissue [6].

Other interactions of PDGFC

  • Furthermore, analysis of a compendium of microarray data revealed significant expression of PDGFA, PDGFC, and PDGFRalpha in human lung tumors [10].
  • An N-terminal CUB domain is encoded by exons 2 and 3 of both genes, and a region of proteolytic cleavage involved in releasing and activating the growth factor domain is located in exon 4 in PDGFC and exon 5 in PDGFD [7].
  • We also show that Arg231 in PDGF-C is essential for tPA-mediated proteolysis and that the released "free" CUB domain of PDGF-C can act as a competitive inhibitor of the cleavage reaction [1].
  • There was differential expression of profibrotic and growth factors that while transforming growth factor-beta induced factor, thrombospondin 1, and platelet derived growth factor-C were up-regulated, vascular endothelial growth factor, epidermal growth factor, and fibroblast growth factors 1 and 9 were downregulated [11].
  • Nuclear localisation of endogenous SUMO-1-modified PDGF-C in human thyroid tissue and cell lines [6].

Analytical, diagnostic and therapeutic context of PDGFC


  1. Structural requirements for activation of latent platelet-derived growth factor CC by tissue plasminogen activator. Fredriksson, L., Ehnman, M., Fieber, C., Eriksson, U. J. Biol. Chem. (2005) [Pubmed]
  2. Platelet-derived growth factor C induces liver fibrosis, steatosis, and hepatocellular carcinoma. Campbell, J.S., Hughes, S.D., Gilbertson, D.G., Palmer, T.E., Holdren, M.S., Haran, A.C., Odell, M.M., Bauer, R.L., Ren, H.P., Haugen, H.S., Yeh, M.M., Fausto, N. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  3. Expression of a novel PDGF isoform, PDGF-C, in normal and diseased rat kidney. Eitner, F., Ostendorf, T., Van Roeyen, C., Kitahara, M., Li, X., Aase, K., Gröne, H.J., Eriksson, U., Floege, J. J. Am. Soc. Nephrol. (2002) [Pubmed]
  4. Characterization of platelet-derived growth factor-C (PDGF-C): expression in normal and tumor cells, biological activity and chromosomal localization. Dijkmans, J., Xu, J., Masure, S., Dhanaraj, S., Gosiewska, A., Geesin, J., Sprengel, J., Harris, S., Verhasselt, P., Gordon, R., Yon, J. Int. J. Biochem. Cell Biol. (2002) [Pubmed]
  5. Expression of platelet-derived growth factors C and D in the synovial membrane of patients with rheumatoid arthritis and osteoarthritis. Pohlers, D., Huber, R., Ukena, B., Kinne, R.W. Arthritis Rheum. (2006) [Pubmed]
  6. Nuclear localisation of endogenous SUMO-1-modified PDGF-C in human thyroid tissue and cell lines. Reigstad, L.J., Martinez, A., Varhaug, J.E., Lillehaug, J.R. Exp. Cell Res. (2006) [Pubmed]
  7. Chromosomal location, exon structure, and vascular expression patterns of the human PDGFC and PDGFC genes. Uutela, M., Laurén, J., Bergsten, E., Li, X., Horelli-Kuitunen, N., Eriksson, U., Alitalo, K. Circulation (2001) [Pubmed]
  8. Dominant negative PDGF-C inhibits growth of Ewing family tumor cell lines. Zwerner, J.P., May, W.A. Oncogene (2002) [Pubmed]
  9. PDGF-C participates in branchial arch morphogenesis and is down-regulated by retinoic acid. Han, J., Li, L., Zhang, Z., Xiao, Y., Lin, J., Li, Y. Toxicol. Lett. (2006) [Pubmed]
  10. Tumor-Driven Paracrine Platelet-Derived Growth Factor Receptor {alpha} Signaling Is a Key Determinant of Stromal Cell Recruitment in a Model of Human Lung Carcinoma. Tejada, M.L., Yu, L., Dong, J., Jung, K., Meng, G., Peale, F.V., Frantz, G.D., Hall, L., Liang, X., Gerber, H.P., Ferrara, N. Clin. Cancer Res. (2006) [Pubmed]
  11. Differential expression of profibrotic and growth factors in chronic allograft nephropathy. Hotchkiss, H., Chu, T.T., Hancock, W.W., Schröppel, B., Kretzler, M., Schmid, H., Liu, Y., Dikman, S., Akalin, E. Transplantation (2006) [Pubmed]
  12. Molecular cloning of SCDGF-B, a novel growth factor homologous to SCDGF/PDGF-C/fallotein. Hamada, T., Ui-Tei, K., Imaki, J., Miyata, Y. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
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