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Gene Review

Pdgfc  -  platelet-derived growth factor, C polypeptide

Mus musculus

Synonyms: 1110064L01Rik, AI647969, Fallotein, PDGF-C, Platelet-derived growth factor C, ...
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Disease relevance of Pdgfc

  • Pdgfc(-/-) Pdgfa(-/-) embryos developed a cleft face, subepidermal blistering, deficiency of renal cortex mesenchyme, spina bifida and skeletal and vascular defects [1].
  • In conclusion, our results suggest that PDGF-C signaling is a new mechanism of cleft palate induced by RA [2].
  • These studies indicate that hepatic expression of PDGF-C induces a number of profibrotic pathways, suggesting that this growth factor may act as an initiator of fibrosis [3].
  • We show that both transient and stable expression of PDGF-C results in the development of liver fibrosis consisting of the deposition of collagen in a pericellular and perivenular pattern that resembles human alcoholic and nonalcoholic fatty liver disease [3].
  • Interestingly, PDGF-C expression was ubiquitous in brain tumor cells and tissues but was very low or absent in normal adult and fetal brain [4].

High impact information on Pdgfc

  • Complete loss of function of both ligands, therefore, phenocopied the loss of PDGFR-alpha function, suggesting that both PDGF-A and PDGF-C signal through PDGFR-alpha to regulate the development of craniofacial structures, the neural tube and mesodermal organs [1].
  • In situ hybridization analysis in the murine embryonic kidney shows preferential expression of PDGF-C messenger RNA in the metanephric mesenchyme during epithelial conversion [5].
  • PDGF-C is activated by proteolysis and induces proliferation of fibroblasts when overexpressed in transgenic mice [5].
  • We further demonstrate that growth of primary fibroblasts in culture is dependent on a tPA-mediated cleavage of latent PDGF-CC, generating a growth stimulatory loop [6].
  • Tissue plasminogen activator is a potent activator of PDGF-CC [6].

Chemical compound and disease context of Pdgfc


Biological context of Pdgfc


Anatomical context of Pdgfc


Associations of Pdgfc with chemical compounds

  • PDGF-C Controls proliferation and is down-regulated by retinoic acid in mouse embryonic palatal mesenchymal cells [2].
  • Our findings demonstrate that administration of bleomycin to murine lungs leads to a significant increase in PDGF-C mRNA expression and a significant decrease in PDGF-D mRNA expression [7].

Regulatory relationships of Pdgfc

  • PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor [5].

Other interactions of Pdgfc


Analytical, diagnostic and therapeutic context of Pdgfc


  1. A specific requirement for PDGF-C in palate formation and PDGFR-alpha signaling. Ding, H., Wu, X., Boström, H., Kim, I., Wong, N., Tsoi, B., O'Rourke, M., Koh, G.Y., Soriano, P., Betsholtz, C., Hart, T.C., Marazita, M.L., Field, L.L., Tam, P.P., Nagy, A. Nat. Genet. (2004) [Pubmed]
  2. PDGF-C Controls proliferation and is down-regulated by retinoic acid in mouse embryonic palatal mesenchymal cells. Han, J., Xiao, Y., Lin, J., Li, Y. Birth Defects Res. B Dev. Reprod. Toxicol. (2006) [Pubmed]
  3. Platelet-derived growth factor C induces liver fibrosis, steatosis, and hepatocellular carcinoma. Campbell, J.S., Hughes, S.D., Gilbertson, D.G., Palmer, T.E., Holdren, M.S., Haran, A.C., Odell, M.M., Bauer, R.L., Ren, H.P., Haugen, H.S., Yeh, M.M., Fausto, N. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  4. Platelet-derived growth factor (PDGF) autocrine signaling regulates survival and mitogenic pathways in glioblastoma cells: evidence that the novel PDGF-C and PDGF-D ligands may play a role in the development of brain tumors. Lokker, N.A., Sullivan, C.M., Hollenbach, S.J., Israel, M.A., Giese, N.A. Cancer Res. (2002) [Pubmed]
  5. PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor. Li, X., Pontén, A., Aase, K., Karlsson, L., Abramsson, A., Uutela, M., Bäckström, G., Hellström, M., Boström, H., Li, H., Soriano, P., Betsholtz, C., Heldin, C.H., Alitalo, K., Ostman, A., Eriksson, U. Nat. Cell Biol. (2000) [Pubmed]
  6. Tissue plasminogen activator is a potent activator of PDGF-CC. Fredriksson, L., Li, H., Fieber, C., Li, X., Eriksson, U. EMBO J. (2004) [Pubmed]
  7. Modulation of PDGF-C and PDGF-D expression during bleomycin-induced lung fibrosis. Zhuo, Y., Zhang, J., Laboy, M., Lasky, J.A. Am. J. Physiol. Lung Cell Mol. Physiol. (2004) [Pubmed]
  8. The mouse Pdgfc gene: dynamic expression in embryonic tissues during organogenesis. Ding, H., Wu, X., Kim, I., Tam, P.P., Koh, G.Y., Nagy, A. Mech. Dev. (2000) [Pubmed]
  9. A potential oncogenic activity of platelet-derived growth factor d in prostate cancer progression. Ustach, C.V., Taube, M.E., Hurst, N.J., Bhagat, S., Bonfil, R.D., Cher, M.L., Schuger, L., Kim, H.R. Cancer Res. (2004) [Pubmed]
  10. PDGF-D is a potent transforming and angiogenic growth factor. Li, H., Fredriksson, L., Li, X., Eriksson, U. Oncogene (2003) [Pubmed]
  11. PDGF C is a selective alpha platelet-derived growth factor receptor agonist that is highly expressed in platelet alpha granules and vascular smooth muscle. Fang, L., Yan, Y., Komuves, L.G., Yonkovich, S., Sullivan, C.M., Stringer, B., Galbraith, S., Lokker, N.A., Hwang, S.S., Nurden, P., Phillips, D.R., Giese, N.A. Arterioscler. Thromb. Vasc. Biol. (2004) [Pubmed]
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