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Tspan3  -  tetraspanin 3

Mus musculus

Synonyms: 1700055K04Rik, OAP-1, OSP-associated protein 1, TM4-A, Tetraspanin TM4-A, ...
 
 
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Disease relevance of Tspan3

 

High impact information on Tspan3

  • The tetraspanin CD151 is a cell-surface molecule known for its strong lateral interaction with the laminin-binding integrin alpha3beta1 [2].
  • In this paper, we define a novel role for alpha3beta1 integrin in association with the tetraspanin CD151 as a component of a cell-cell adhesion complex in epithelial cells that directly stimulates cadherin-mediated adhesion [4].
  • Overexpression of OSP/claudin-11 or OAP-1 induced proliferation in an oligodendrocyte cell line [5].
  • The tetraspanin CD9 mediates lateral association of MHC class II molecules on the dendritic cell surface [6].
  • Mice lacking CD81 (TAPA-1), a widely expressed tetraspanin molecule, have impaired antibody responses to protein antigens [7].
 

Biological context of Tspan3

  • Amino acid sequence analysis of the Tspans highlights conserved residues which may be critical to tetraspanin structure and function [8].
  • Taken together, our results indicate that palmitoylation is crucial for the functional integrity of tetraspanin KAI1/CD82 during the suppression of cancer cell migration and invasion [9].
  • The mRNA expression of a tetraspanin transmembrane protein, CD9, was high in undifferentiated ES cells and decreased shortly after cell differentiation [10].
  • Wound healing is defective in mice lacking tetraspanin CD151 [11].
  • Tetraspanin CD9 regulates invasion during mouse embryo implantation [12].
 

Anatomical context of Tspan3

 

Associations of Tspan3 with chemical compounds

  • On PKC inhibition, integrin beta 1 and PKC epsilon become reversibly trapped in a tetraspanin (CD81)-positive intracellular compartment, correlating with reduced haptotaxis [16].
  • Here, using a new monoclonal antibody that only binds to the tetraspanin CD81 associated with other tetraspanins, we show that membrane cholesterol contributes to the organization of tetraspanin microdomains on the surface of live cells [17].
  • In the present study the effects of the HDAC inhibitor trichostatin A (TSA) on the tetraspanin cell surface antigen CD9 were determined in primary murine macrophages [18].
  • CD9 and CD63 belong to a tetramembrane-spanning glycoprotein family called tetraspanin, and are involved in a wide variety of cellular processes, but the structure-function relationship of this family of proteins has yet to be clarified [19].
 

Other interactions of Tspan3

 

Analytical, diagnostic and therapeutic context of Tspan3

  • Mice were immunized with cells having a high expression of the chosen tetraspanin and the constructs were used to screen hybridomas in a solid phase ELISA [21].

References

  1. Hepatocyte CD81 is required for Plasmodium falciparum and Plasmodium yoelii sporozoite infectivity. Silvie, O., Rubinstein, E., Franetich, J.F., Prenant, M., Belnoue, E., Rénia, L., Hannoun, L., Eling, W., Levy, S., Boucheix, C., Mazier, D. Nat. Med. (2003) [Pubmed]
  2. Kidney failure in mice lacking the tetraspanin CD151. Sachs, N., Kreft, M., van den Bergh Weerman, M.A., Beynon, A.J., Peters, T.A., Weening, J.J., Sonnenberg, A. J. Cell Biol. (2006) [Pubmed]
  3. A functionally relevant conformational epitope on the CD9 tetraspanin depends on the association with activated beta1 integrin. Gutierrez-Lopez, M.D., Ovalle, S., Yanez-Mo, M., Sanchez-Sanchez, N., Rubinstein, E., Olmo, N., Lizarbe, M.A., Sanchez-Madrid, F., Cabanas, C. J. Biol. Chem. (2003) [Pubmed]
  4. alpha3beta1 integrin-CD151, a component of the cadherin-catenin complex, regulates PTPmu expression and cell-cell adhesion. Chattopadhyay, N., Wang, Z., Ashman, L.K., Brady-Kalnay, S.M., Kreidberg, J.A. J. Cell Biol. (2003) [Pubmed]
  5. OSP/claudin-11 forms a complex with a novel member of the tetraspanin super family and beta1 integrin and regulates proliferation and migration of oligodendrocytes. Tiwari-Woodruff, S.K., Buznikov, A.G., Vu, T.Q., Micevych, P.E., Chen, K., Kornblum, H.I., Bronstein, J.M. J. Cell Biol. (2001) [Pubmed]
  6. The tetraspanin CD9 mediates lateral association of MHC class II molecules on the dendritic cell surface. Unternaehrer, J.J., Chow, A., Pypaert, M., Inaba, K., Mellman, I. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
  7. CD81 on B cells promotes interleukin 4 secretion and antibody production during T helper type 2 immune responses. Maecker, H.T., Do, M.S., Levy, S. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  8. Sequences and expression of six new members of the tetraspanin/TM4SF family. Todd, S.C., Doctor, V.S., Levy, S. Biochim. Biophys. Acta (1998) [Pubmed]
  9. The palmitoylation of metastasis suppressor KAI1/CD82 is important for its motility- and invasiveness-inhibitory activity. Zhou, B., Liu, L., Reddivari, M., Zhang, X.A. Cancer Res. (2004) [Pubmed]
  10. CD9 is associated with leukemia inhibitory factor-mediated maintenance of embryonic stem cells. Oka, M., Tagoku, K., Russell, T.L., Nakano, Y., Hamazaki, T., Meyer, E.M., Yokota, T., Terada, N. Mol. Biol. Cell (2002) [Pubmed]
  11. Wound healing is defective in mice lacking tetraspanin CD151. Cowin, A.J., Adams, D., Geary, S.M., Wright, M.D., Jones, J.C., Ashman, L.K. J. Invest. Dermatol. (2006) [Pubmed]
  12. Tetraspanin CD9 regulates invasion during mouse embryo implantation. Liu, W.M., Cao, Y.J., Yang, Y.J., Li, J., Hu, Z., Duan, E.K. J. Mol. Endocrinol. (2006) [Pubmed]
  13. Molecular cloning and characterization of mouse Tspan-3, a novel member of the tetraspanin superfamily, expressed on resting dendritic cells. Tokoro, Y., Shibuya, K., Osawa, M., Tahara-Hanaoka, S., Iwama, A., Kitamura, T., Nakauchi, H., Shibuya, A. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  14. The molecular characterisation of mouse tspan-3. Puls, K.L., Wright, M.D. DNA Seq. (2000) [Pubmed]
  15. Impaired CD19 expression and signaling, enhanced antibody response to type II T independent antigen and reduction of B-1 cells in CD81-deficient mice. Tsitsikov, E.N., Gutierrez-Ramos, J.C., Geha, R.S. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  16. PKC epsilon controls the traffic of beta1 integrins in motile cells. Ivaska, J., Whelan, R.D., Watson, R., Parker, P.J. EMBO J. (2002) [Pubmed]
  17. Cholesterol contributes to the organization of tetraspanin-enriched microdomains and to CD81-dependent infection by malaria sporozoites. Silvie, O., Charrin, S., Billard, M., Franetich, J.F., Clark, K.L., van Gemert, G.J., Sauerwein, R.W., Dautry, F., Boucheix, C., Mazier, D., Rubinstein, E. J. Cell. Sci. (2006) [Pubmed]
  18. Histone deacetylase inhibition results in decreased macrophage CD9 expression. Wang, X.Q., Alfaro, M.L., Evans, G.F., Zuckerman, S.H. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  19. Domain analysis of the tetraspanins: studies of CD9/CD63 chimeric molecules on subcellular localization and upregulation activity for diphtheria toxin binding. Ryu, F., Takahashi, T., Nakamura, K., Takahashi, Y., Kobayashi, T., Shida, S., Kameyama, T., Mekada, E. Cell Struct. Funct. (2000) [Pubmed]
  20. Developmental expression of OAP-1/Tspan-3, a member of the tetraspanin superfamily. Tiwari-Woodruff, S.K., Kaplan, R., Kornblum, H.I., Bronstein, J.M. J. Neurosci. Res. (2004) [Pubmed]
  21. A general approach to the generation of monoclonal antibodies against members of the tetraspanin superfamily using recombinant GST fusion proteins. Azorsa, D.O., Moog, S., Cazenave, J.P., Lanza, F. J. Immunol. Methods (1999) [Pubmed]
 
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