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Gene Review

CLDN11  -  claudin 11

Homo sapiens

Synonyms: Claudin-11, OSP, OTM, Oligodendrocyte-specific protein
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Disease relevance of CLDN11


Psychiatry related information on CLDN11

  • Making the pessimistic assumption that there will be 5000 deaths during the variant Creutzfeldt-Jakob disease (vCJD) epidemic in total, our analysis indicates that replacement of the OTM rule with testing would result in 0.04 additional vCJD deaths over the next 60 years [6].
  • The present study set out to assess if the different probabilities reported in the literature of obtaining equivalence after baseline training with MTO and OTM protocols could be attributed to individual differences and, if so, whether equivalence formation could be facilitated by using familiar stimuli as nodes [7].
  • Here, we investigated oligodendrocyte-specific and myelination-associated gene expression in schizophrenia and bipolar affective disorder [8].

High impact information on CLDN11


Chemical compound and disease context of CLDN11

  • As such, lesions along this shared pathway, such as occur in neurologically complete injury to the cervical spinal cord (tetraplegia), would be predicted to result in simultaneous OSP and loss of pineal melatonin production [5].

Biological context of CLDN11


Anatomical context of CLDN11


Associations of CLDN11 with chemical compounds

  • A testosterone induced acceleration of oligodendrocyte maturation could be detected in several brain areas by using the monoclonal antibody O 10 recognizing an oligodendrocyte-specific cell surface antigen and by the silver impregnation for myelin [18].
  • Alpha-chymotrypsin, which has a potential for use in industrial applications, was covalently modified by reductive alkylation using polymeric sucrose (OSP, molecular weight 70 and 400 kDa), dextran (73 and 250 kDa) and carboxymethyl cellulose (CMC, approximately 12 kDa) [19].
  • At higher concentrations of up to 2.5x10(-2) induced DNA migration was expressed by OTM of 3.3 for HEMA, 4.5 for TEGDMA, 7.4 for Bis-GMA, and 2.8 for UDMA [20].
  • The Japan Institute for the Control of Aging (JaICA) and Genox have jointly developed a profiling technique to measure the "Oxidative Stress Profiles (JaICA-Genox OSP)" of individuals and laboratory test animals [21].
  • One protein synthesized de novo, the estrogen-dependent oviductal secretory glycoprotein (OSP), has been shown to be unique to the oviduct and is conserved across a number of mammalian species [22].

Other interactions of CLDN11


Analytical, diagnostic and therapeutic context of CLDN11


  1. Involvement of OSP/claudin-11 in oligodendrocyte membrane interactions: role in biology and disease. Bronstein, J.M., Tiwari-Woodruff, S., Buznikov, A.G., Stevens, D.B. J. Neurosci. Res. (2000) [Pubmed]
  2. Oligodendrocyte survival, loss and birth in lesions of chronic-stage multiple sclerosis. Wolswijk, G. Brain (2000) [Pubmed]
  3. Plastic phenotype of human oligodendroglial tumour cells in vitro. Tenenbaum, L., Teugels, E., Dogusan, Z., Avellana-Adalid, V., Hooghe-Peters, E.L. Neuropathol. Appl. Neurobiol. (1996) [Pubmed]
  4. Mitochondrial disease activates transcripts of the unfolded protein response and cell cycle and inhibits vesicular secretion and oligodendrocyte-specific transcripts. Cortopassi, G., Danielson, S., Alemi, M., Zhan, S.S., Tong, W., Carelli, V., Martinuzzi, A., Marzuki, S., Majamaa, K., Wong, A. Mitochondrion (2006) [Pubmed]
  5. Bilateral oculosympathetic paresis associated with loss of nocturnal melatonin secretion in patients with spinal cord injury. Zeitzer, J.M., Ayas, N.T., Wu, A.D., Czeisler, C.A., Brown, R. The journal of spinal cord medicine. (2005) [Pubmed]
  6. Assessment of the risk posed by bovine spongiform encephalopathy in cattle in Great Britain and the impact of potential changes to current control measures. Ferguson, N.M., Donnelly, C.A. Proc. Biol. Sci. (2003) [Pubmed]
  7. Establishing equivalence classes in preschool children with one-to-many and many-to-one training protocols. Smeets, P.M., Barnes-Holmes, D. Behav. Processes (2005) [Pubmed]
  8. Oligodendrocyte dysfunction in schizophrenia and bipolar disorder. Tkachev, D., Mimmack, M.L., Ryan, M.M., Wayland, M., Freeman, T., Jones, P.B., Starkey, M., Webster, M.J., Yolken, R.H., Bahn, S. Lancet (2003) [Pubmed]
  9. OSP/claudin-11 forms a complex with a novel member of the tetraspanin super family and beta1 integrin and regulates proliferation and migration of oligodendrocytes. Tiwari-Woodruff, S.K., Buznikov, A.G., Vu, T.Q., Micevych, P.E., Chen, K., Kornblum, H.I., Bronstein, J.M. J. Cell Biol. (2001) [Pubmed]
  10. An oligodendrocyte-specific zinc-finger transcription regulator cooperates with Olig2 to promote oligodendrocyte differentiation. Wang, S.Z., Dulin, J., Wu, H., Hurlock, E., Lee, S.E., Jansson, K., Lu, Q.R. Development (2006) [Pubmed]
  11. Origin of oligodendrocytes within the human spinal cord. Hajihosseini, M., Tham, T.N., Dubois-Dalcq, M. J. Neurosci. (1996) [Pubmed]
  12. A humoral response to oligodendrocyte-specific protein in MS: a potential molecular mimic. Bronstein, J.M., Lallone, R.L., Seitz, R.S., Ellison, G.W., Myers, L.W. Neurology (1999) [Pubmed]
  13. Myelin basic protein functions as a microtubule stabilizing protein in differentiated oligodendrocytes. Galiano, M.R., Andrieux, A., Deloulme, J.C., Bosc, C., Schweitzer, A., Job, D., Hallak, M.E. J. Neurosci. Res. (2006) [Pubmed]
  14. Oligodendrocyte gene expression in the human fetal spinal cord during the second trimester of gestation. Grever, W.E., Weidenheim, K.M., Tricoche, M., Rashbaum, W.K., Lyman, W.D. J. Neurosci. Res. (1997) [Pubmed]
  15. Modelling studies on bovine spongiform encephalopathy occurrence to assist in the review of the over 30 months rule in Great Britain. Arnold, M., Wilesmith, J. Proc. Biol. Sci. (2003) [Pubmed]
  16. Developmental expression of OSP/claudin-11. Bronstein, J.M., Chen, K., Tiwari-Woodruff, S., Kornblum, H.I. J. Neurosci. Res. (2000) [Pubmed]
  17. Novel microtubule-associated protein-2 isoform is expressed early in human oligodendrocyte maturation. Shafit-Zagardo, B., Davies, P., Rockwood, J., Kress, Y., Lee, S.C. Glia (2000) [Pubmed]
  18. Application of testosterone accelerates oligodendrocyte maturation in brains of zebra finches. Kafitz, K.W., Herth, G., Bartsch, U., Güttinger, H.R., Schachner, M. Neuroreport (1992) [Pubmed]
  19. Retardation of thermal and urea induced inactivation of alpha-chymotrypsin by modification with carbohydrate polymers. Sundaram, P.V., Venkatesh, R. Protein Eng. (1998) [Pubmed]
  20. Genotoxicity and cytotoxicity of dental materials in human lymphocytes as assessed by the single cell microgel electrophoresis (comet) assay. Kleinsasser, N.H., Wallner, B.C., Harréus, U.A., Kleinjung, T., Folwaczny, M., Hickel, R., Kehe, K., Reichl, F.X. Journal of dentistry. (2004) [Pubmed]
  21. The JaICA-genox oxidative stress profile--an overview on the profiling technique in the oxidative stress assessment and management. Ochi, H., Cheng, R.Z., Kantha, S.S., Takeuchi, M., Ramarathnam, N. Biofactors (2000) [Pubmed]
  22. Secreted proteins of the oviduct. Buhi, W.C., Alvarez, I.M., Kouba, A.J. Cells Tissues Organs (Print) (2000) [Pubmed]
  23. A novel microtubule-associated protein-2 expressed in oligodendrocytes in multiple sclerosis lesions. Shafit-Zagardo, B., Kress, Y., Zhao, M.L., Lee, S.C. J. Neurochem. (1999) [Pubmed]
  24. Reactive oxygen species mediate activity-dependent neuron-glia signaling in output fibers of the hippocampus. Atkins, C.M., Sweatt, J.D. J. Neurosci. (1999) [Pubmed]
  25. Cerebrospinal fluid immunoglobulin G promotes oligodendrocyte progenitor cell migration. Tiwari-Woodruff, S.K., Myers, L.W., Bronstein, J.M. J. Neurosci. Res. (2004) [Pubmed]
  26. Fluvastatin and lovastatin but not pravastatin induce neuroglial differentiation in human mesenchymal stem cells. Lee, O.K., Ko, Y.C., Kuo, T.K., Chou, S.H., Li, H.J., Chen, W.M., Chen, T.H., Su, Y. J. Cell. Biochem. (2004) [Pubmed]
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