Disease relevance of SAR1A

• Using a nucleotide sequence-based genetic typing method, multilocus sequence typing, we were able for the first time to match clonal cultivable isolates to a published and controversial bacterial metagenome, Burkholderia SAR-1, which derived from analysis of the Sargasso Sea [1].
• Sara Hodgson reports the findings of a study in the Oxford region to determine the safety and immunogenicity of the Hib conjugate vaccine PRP-T when given to British infants in concurrence with primary immunisations, according to the accelerated schedule of two, three and four months of age [2].
• METHODS: The authors devised the Scale for the Assessment and Rating of Ataxia (SARA) and tested it in two trials of 167 and 119 patients with spinocerebellar ataxia [3].
• Within the SARA group, those with antibodies against HTLV-III/LAV had percentages of ARFC significantly lower than SARA with negative antibodies [4].

Psychiatry related information on SAR1A

• SARA score increased with the disease stage (p < 0.001) and was closely correlated with the Barthel Index (r = -0.80, p < 0.001) and part IV (functional assessment) of the Unified Huntington's Disease Rating Scale (UHDRS-IV) (r = -0.89, p < 0.0001), whereas it had only a weak correlation with disease duration (r = 0.34, p < 0.0002) [3].

High impact information on SAR1A

• In this issue of Neuron, Sara et al. find that spontaneously released miniature synaptic potentials arise from a pool of vesicles distinct from those released by neural activity [5].
• Analysis in a permeabilized cell assay indicated that up-regulation of COPII assembly occurred in the absence GTP hydrolysis and any cytosolic factors other than the COPII prebudding complex Sar1p-Sec23p-Sec24p [6].
• The formation of transport vesicles that bud from endoplasmic reticulum (ER) exit sites is dependent on the COPII coat made up of three components: the small GTPase Sar1, the Sec23/24 complex, and the Sec13/31 complex [7].
• Furthermore, we propose a mechanism for COPII assembly and disassembly in which dimerization of Sar1 plays an important role [8].
• Results. Overall, there were no statistically significant differences between PSC patients and controls in genotype and allele frequencies for the CTLA4 +49AG and CT60 SNPs or for the CD28-A, CD28-B, SARA43, SARA1, SARA31, and SARA47 microsatellite markers [9].

Biological context of SAR1A

• We hybridized whole human chromosome-specific DNA libraries to chromosomes of two supposed subspecies of Alouatta seniculus: Alouatta seniculus sara and Alouatta seniculus arctoides [10].
• The number of hybridization signals per haploid set is 42 in A. s. sara and 43 in A. s. arctoidea; the two karyotypes differ by at least 16 chromosomal rearrangements, including numerous translocations [10].
• Our new SARA (SQUID Array for Reproductive Assessment) is a unique MEG device designed specifically for the study of the fetal neurophysiology [11].
• Here Dr Sara Levene, medical consultant to the Child Accident Prevention Trust, considers accidents, a major problem which health visitors can do much to control [12].
• Comparison of the Burkholderia SAR-1 metagenome to closely related B. cepacia complex genomes indicated that it was greater than 98% intact in terms of conserved genes, and it also shared complete sequence identity with the cultivable isolates at random loci beyond the genes sampled by the multilocus sequence typing [1].

Anatomical context of SAR1A

• Agglutination percentages of red blood cells from European and from three African populations (Twareg from Mali, Sara from Central African Republic, and Niokholonko from Senegal) in the ABO system have been compared [13].
• We performed recording of the magnetic fields (Magnetomyography - MMG) corresponding to the electrical activity of the uterine smooth muscle with a device called SARA, (SQuid Array for Reproductive Assessment) [14].
• These results indicate that SARA possess a depletion of this subpopulation of T cells [4].
• The mean percentage of ARFC of SARA had a direct linear correlation with the percentage of T4+ cells (p less than 0.01) [4].
• PtdIns4P was utilized to support Sar1-induced proliferation and constriction of ERES membranes [15].

Associations of SAR1A with chemical compounds

• PPG-SARA read desflurane mainly as isoflurane(I) and, to a lesser extent, as nitrous oxide [16].
• PPG-SARA read sevoflurane mainly as enflurane(E) and, to a lesser extent, as nitrous oxide and halothane [16].
• Desflurane 0% to 18% in 3% increments or sevoflurane 0% to 7% in 1% increments in 5-L/min oxygen was delivered to the Advantage and PPG-SARA mass spectrometry systems [16].
• Unenforceable today, enforceable tomorrow--Illinois Supreme Court reverses Berlin decision. Richard B. Berlin, Jr., M.D. v. Sara Bush Lincoln Health Center [17].

Analytical, diagnostic and therapeutic context of SAR1A

• In this paper, we review the current progress in the area of fetal magnetoencephalography (fMEG) and also present an overview of the studies performed using a system called SARA that is specifically designed for fetal MEG studies [18].
• Through in-depth interviews and archival research, we trace the origins of female circumcision among this group and examine its role and function in the context of contemporary Sara culture [19].
• SARA ratings showed a linear relation to global assessments using a visual analogue scale, suggesting linearity of the scale (p < 0.0001, r(2) = 0.98) [3].
• In this Comment, Sara Petersen proposes that courts should draw upon contract law principles in determining whether the parties to such conflicts actually reached agreements regarding embryo disposition in the event of divorce [20].
• In its present configuration the system records information from a Spacelabs 500 series physiologic monitor, Hewlett-Packard physiologic monitor with the Careport computer interface, SARA mass spectrometer, Nellcor pulse oximeter, Neurotrac processed EEG, Lawrence cardiac output monitor, Hewlett-Packard capnometer, and Bourns spirometer [21].

References