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Gene Review

QARS  -  glutaminyl-tRNA synthetase

Homo sapiens

Synonyms: GLNRS, GlnRS, Glutamine--tRNA ligase, Glutaminyl-tRNA synthetase, MSCCA, ...
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Disease relevance of QARS


High impact information on QARS


Biological context of QARS


Anatomical context of QARS


Associations of QARS with chemical compounds


Other interactions of QARS


  1. Evolution of the Glx-tRNA synthetase family: the glutaminyl enzyme as a case of horizontal gene transfer. Lamour, V., Quevillon, S., Diriong, S., N'Guyen, V.C., Lipinski, M., Mirande, M. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  2. Quarantine Activity Reporting System (QARS). Krishnamurthy, R., Remis, M., Brooke, L., Miller, C., Navin, A., Guerra, M. AMIA ... Annual Symposium proceedings / AMIA Symposium. AMIA Symposium (2006) [Pubmed]
  3. Protein biosynthesis in organelles requires misaminoacylation of tRNA. Schön, A., Kannangara, C.G., Gough, S., Söll, D. Nature (1988) [Pubmed]
  4. Gene descent, duplication, and horizontal transfer in the evolution of glutamyl- and glutaminyl-tRNA synthetases. Brown, J.R., Doolittle, W.F. J. Mol. Evol. (1999) [Pubmed]
  5. Activation of microhelix charging by localized helix destabilization. Alexander, R.W., Nordin, B.E., Schimmel, P. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  6. An EcoRI polymorphism for the glutaminyl-tRNA synthetase (QARS) gene on chromosome 1q. Sander, A.K., Liechti-Gallati, S., Kunze, N., Moser, H., Zingg, M., Raveh, J. Hum. Mol. Genet. (1992) [Pubmed]
  7. tRNA-dependent aminoacyl-adenylate hydrolysis by a nonediting class I aminoacyl-tRNA synthetase. Gruic-Sovulj, I., Uter, N., Bullock, T., Perona, J.J. J. Biol. Chem. (2005) [Pubmed]
  8. Exons encoding the highly conserved part of human glutaminyl-tRNA synthetase. Kaiser, E., Eberhard, D., Knippers, R. J. Mol. Evol. (1992) [Pubmed]
  9. Slow solvation dynamics at the active site of an enzyme: implications for catalysis. Guha, S., Sahu, K., Roy, D., Mondal, S.K., Roy, S., Bhattacharyya, K. Biochemistry (2005) [Pubmed]
  10. Dynamics of compact denatured states of glutaminyl-tRNA synthetase probed by bis-ANS binding kinetics. Bhattacharyya, A., Mandal, A.K., Banerjee, R., Roy, S. Biophys. Chem. (2000) [Pubmed]
  11. Stressing out over survival: glutamine as an apoptotic modulator. Fuchs, B.C., Bode, B.P. J. Surg. Res. (2006) [Pubmed]
  12. The human QARS locus: assignment of the human gene for glutaminyl-tRNA synthetase to chromosome 1q32-42. Kunze, N., Bittler, E., Fett, R., Schray, B., Hameister, H., Wiedorn, K.H., Knippers, R. Hum. Genet. (1990) [Pubmed]
  13. Glutamine-dependent antiapoptotic interaction of human glutaminyl-tRNA synthetase with apoptosis signal-regulating kinase 1. Ko, Y.G., Kim, E.Y., Kim, T., Park, H., Park, H.S., Choi, E.J., Kim, S. J. Biol. Chem. (2001) [Pubmed]
  14. Divergence of glutamate and glutamine aminoacylation pathways: providing the evolutionary rationale for mischarging. Rogers, K.C., Söll, D. J. Mol. Evol. (1995) [Pubmed]
  15. Retracing the evolution of amino acid specificity in glutaminyl-tRNA synthetase. Hong, K.W., Ibba, M., Söll, D. FEBS Lett. (1998) [Pubmed]
  16. Macromolecular assemblage of aminoacyl-tRNA synthetases: quantitative analysis of protein-protein interactions and mechanism of complex assembly. Robinson, J.C., Kerjan, P., Mirande, M. J. Mol. Biol. (2000) [Pubmed]
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