Disease relevance of EPRS

• This study demonstrates that despite an allergen-mediated pulmonary eosinophilia and earlier studies showing that Ears are constituents of eosinophil secondary granules, alveolar macrophages are a significant source of these RNases in lungs of OVA-treated mice [1].
• INTERVENTION: Pars plana vitrectomy for standard macular hole repair performed by multiple surgeons [2].
• INTERVENTION: Pars plana vitrectomy and epiretinal membrane stripping [3].
• INTERVENTIONS: Pars plana vitrectomy; foreign body removal; additional surgical procedures according to the clinical situation [4].
• CONCLUSIONS: Pars plana vitrectomy appears to be relatively safe and effective in treating massive macular hemorrhage caused by a retinal arterial macroaneurysm [5].

High impact information on EPRS

• Here we investigate the effects of the naturally occurring threonine-linked L-fucose moiety on the structure, dynamics and stability of the proteinase inhibitor PMP-C (Pars intercerebralis major peptide C) [6].
• An EcoRI polymorphism for the glutaminyl-tRNA synthetase (QARS) gene on chromosome 1q [7].
• After screening 3 x 10(6) clones from 3 different cDNA libraries, 15 tumor antigens were identified, including cytokeratin 2-8, glutamyl-prolyl-tRNA synthetase, complement C3, galectin 8, and serine/threonine-rich protein kinase 1 [8].
• We found that hDUS2 protein had tRNA-DUS activity and that it physically interacted with EPRS, a glutamyl-prolyl tRNA synthetase, and was likely to enhance translational efficiencies [9].
• The EPRS repeats also showed the binding activity to the N-terminal motif of arginyl-tRNA synthetase as well as to various nucleic acids, including tRNA [10].

Chemical compound and disease context of EPRS

• Gene Expression Profiling of Sporadic Parkinson's Disease Substantia Nigra Pars Compacta Reveals Impairment of Ubiquitin-Proteasome Subunits, SKP1A, Aldehyde Dehydrogenase, and Chaperone HSC-70 [11].
• CONCLUSION: Pars plana vitrectomy can be an effective treatment for diabetic macular edema refractory to laser therapy and/or sub-Tenon's capsule steroid injection [12].
• PARTICIPANTS: Fifty-five United States military personnel with an IOFB injury during Operation Iraqi Freedom. INTERVENTION: Pars plana vitrectomy, foreign body removal, and additional surgical procedures as the clinical situation dictated [13].

Biological context of EPRS

• Tandem repeats located in the human bifunctional glutamyl-prolyl-tRNA synthetase (EPRS) have been found in many different eukaryotic tRNA synthetases and were previously shown to interact with another distinct repeated motifs in human isoleucyl-tRNA synthetase [10].
• We report the structure of the human EPRS gene, which consists of 29 exons spread over at least 90 kb of genomic DNA [14].
• The human QARS locus: assignment of the human gene for glutaminyl-tRNA synthetase to chromosome 1q32-42 [15].
• It comprises a helix-turn-helix (HTH) motif related to the repeated units of the linker region of bifunctional glutamyl-prolyl-tRNA synthetase, and a specific C-terminal KGKKKK lysine-rich cluster (LRC) [16].
• CONCLUSIONS: Pars plana vitrectomy to evacuate massive subretinal hemorrhage can improve visual acuity, but final visual acuity is limited by the underlying disease [17].

Anatomical context of EPRS

• INTERVENTION: Pars plana vitrectomy for removal of massive foveal exudates was performed [18].
• CONCLUSIONS: Pars plana lensectomy-vitrectomy and anterior chamber intraocular lens implantation appears to be an excellent technique for the management of ectopia lentis associated with Marfan syndrome [19].
• Perović also described the part of the vomer behind this crest was shaped as a cone, and termed it Pars cuneiformis vomeris [20].
• Adopting intraoperative monitoring of the facial nerve and the cochlea as well as the Pars acustica by means of far-field and near-field electrodes, a good facial 'mobility' was achieved in 95.3%, and a useful audition (AAO-HNS Types A and B) in 60% [21].

Other interactions of EPRS

• Serological responses to three antigens (C21ORF2, EPRS and NAP1L1) were found mainly in cancer patients' sera [22].

Analytical, diagnostic and therapeutic context of EPRS

• Interaction of hsp90 with human glutamyl-prolyl-tRNA synthetase (EPRS) was found by genetic screening, co-immunoprecipitation, and in vitro binding experiments [23].
• INTERVENTION: Pars plana vitrectomy, posterior hyaloid peeling, fluid-air and air-gas exchange with a nonexpansile 17% C2F6 mixture followed by face-down positioning [24].
• INTERVENTION: Pars plana vitrectomy and scleral buckling procedure in the left eye with intravenous and intravitreal amphotericin in both eyes [25].
• METHODS: Pars plana vitrectomy was performed in the 12 eyes, followed by posterior hyaloid dissection, removal of the posterior inner limiting membrane after staining with indocyanine green, and gas tamponade [26].
• A comparison has been made between pars plana lansectomy and intracapsular cataract extraction Pars plana lensectomy has been shown to have many advantages [27].

References