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Chemical Compound Review

Carisoma     [2-(aminocarbonyloxymethyl)- 2-methyl...

Synonyms: Atonalyt, Somalgit, Soprodol, Isobamate, SOMA, ...
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Disease relevance of meprobamate

  • Treatment of hypotension in meprobamate poisoning [1].
  • Meprobamate poisoning and pulmonary edema [2].
  • The initial Subjective Objective Medical management and Analytic (SOMA) injury evaluation score was 13.2 +/- 5.9 and included evidence of edema, plexitis, restricted movement, and local inflammatory signs [3].
  • The TDC group had fewer Grade 3 or 4 acute and chronic toxicities and lower SOMA scores [4].
  • Xerostomia was defined according to the subjective, objective, management, analytic (SOMA) criteria as occurring when posttreatment salivary function was < 25% of the pretreatment function [5].

Psychiatry related information on meprobamate


High impact information on meprobamate


Chemical compound and disease context of meprobamate


Biological context of meprobamate


Anatomical context of meprobamate

  • PURPOSE: To examine the Late Effects Normal Tissue Task Force (LENT)-Subjective, Objective, Management, Analytic (SOMA) scales prospectively in carcinoma of the cervix treated curatively with radiotherapy (RT) using interviews and postal questionnaires and to test the sensitivity of the scales in assessing the radiation effects [22].
  • The small intestine/colon SOMA median score was 0.1538 (range 0-1) and the rectal SOMA median score was 0.1428 (range 0-1) [23].
  • Subjective, objective, management, and analytic (SOMA) parameters related to radiation spinal cord and brain injury have been developed and presented on ordinal scales [24].
  • Late toxicity results of the GORTEC 94-01 randomized trial comparing radiotherapy with concomitant radiochemotherapy for advanced-stage oropharynx carcinoma: comparison of LENT/SOMA, RTOG/EORTC, and NCI-CTC scoring systems [25].
  • Transfer of carisoprodol to breast milk [26].

Associations of meprobamate with other chemical compounds


Gene context of meprobamate

  • Most studies on carisoprodol metabolism have been carried out on individuals phenotyped for CYP2C19 activity using the probe drug S-mephenytoin [11].
  • The effect of a purified somatostatin monoclonal antibody, SOMA 10, and its Fab fragments on gastrin release have been examined in the isolated perfused rat stomach [30].
  • Serum meprobamate concentrations exceeding 12 mg/dl were consistent with coma [31].
  • Lineage A contained Flexal, Parana, Pichinde, and Tamiami viruses; lineage B contained Amapari, Guanarito (GUA), Junin (JUN), Machupo (MAC), Sabia (SAB), and Tacaribe viruses [32].
  • In spiked human sera, protein binding of carisoprodol was in the range of 41-67%, whereas meprobamate was bound to a lesser extent, 14-24% [33].

Analytical, diagnostic and therapeutic context of meprobamate


  1. Treatment of hypotension in meprobamate poisoning. Lhoste, F., Lemaire, F., Rapin, M. N. Engl. J. Med. (1977) [Pubmed]
  2. Meprobamate poisoning and pulmonary edema. Axelson, J.A., Hagaman, J.F. N. Engl. J. Med. (1977) [Pubmed]
  3. Striking regression of chronic radiotherapy damage in a clinical trial of combined pentoxifylline and tocopherol. Delanian, S., Balla-Mekias, S., Lefaix, J.L. J. Clin. Oncol. (1999) [Pubmed]
  4. Tissue/dose compensation to reduce toxicity from combined radiation and chemotherapy for advanced head and neck cancers. Mittal, B.B., Kepka, A., Mahadevan, A., Kies, M., Pelzer, H., List, M.A., Rademaker, A., Logemann, J. Int. J. Cancer (2001) [Pubmed]
  5. Dose-volume modeling of salivary function in patients with head-and-neck cancer receiving radiotherapy. Blanco, A.I., Chao, K.S., El Naqa, I., Franklin, G.E., Zakarian, K., Vicic, M., Deasy, J.O. Int. J. Radiat. Oncol. Biol. Phys. (2005) [Pubmed]
  6. Anxiety, anxiolytics and brain stimulation reinforcement. Liebman, J.M. Neuroscience and biobehavioral reviews. (1985) [Pubmed]
  7. Impairment due to intake of carisoprodol. Bramness, J.G., Skurtveit, S., Mørland, J. Drug and alcohol dependence. (2004) [Pubmed]
  8. Phase II study of vitamin E and pentoxifylline in patients with late side effects of pelvic radiotherapy. Gothard, L., Cornes, P., Brooker, S., Earl, J., Glees, J., Hall, E., Peckitt, C., Tait, D., Yarnold, J. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. (2005) [Pubmed]
  9. A test of anxiety that distinguishes between the actions of benzodiazepines and those of other minor tranquilisers and of stimulants. File, S.E., Hyde, J.R. Pharmacol. Biochem. Behav. (1979) [Pubmed]
  10. NTP toxicity studies of carisoprodol (CAS No. 78-44-4) administered by Gavage to F344/N rats and B6C3F1 mice. Chan, P.C. Toxicity report series. (2000) [Pubmed]
  11. Association between blood carisoprodol:meprobamate concentration ratios and CYP2C19 genotype in carisoprodol-drugged drivers: decreased metabolic capacity in heterozygous CYP2C19*1/CYP2C19*2 subjects? Bramness, J.G., Skurtveit, S., Fauske, L., Grung, M., Molven, A., Mørland, J., Steen, V.M. Pharmacogenetics (2003) [Pubmed]
  12. Comparative abuse liability and pharmacological effects of meprobamate, triazolam, and butabarbital. Zawertailo, L.A., Busto, U.E., Kaplan, H.L., Greenblatt, D.J., Sellers, E.M. Journal of clinical psychopharmacology. (2003) [Pubmed]
  13. Formation of meprobamate from carisoprodol is catalysed by CYP2C19. Dalén, P., Alvan, G., Wakelkamp, M., Olsen, H. Pharmacogenetics (1996) [Pubmed]
  14. Comparative efficacy and safety of skeletal muscle relaxants for spasticity and musculoskeletal conditions: a systematic review. Chou, R., Peterson, K., Helfand, M. Journal of pain and symptom management. (2004) [Pubmed]
  15. Treatment of fibromyalgia (fibrositis syndrome): a parallel double blind trial with carisoprodol, paracetamol and caffeine (Somadril comp) versus placebo. Vaerøy, H., Abrahamsen, A., Førre, O., Kåss, E. Clin. Rheumatol. (1989) [Pubmed]
  16. Psychopharmacological analysis of hypothalamically-induced emotions. Korelli, A.G., Davituliani, D.S. Acta physiologica Hungarica. (1988) [Pubmed]
  17. Comparison of changes in the pain threshold following oral administration of carisoprodol, acetylsalicylic acid, and placebo. A trial on volunteers. Dahl, E., Grenthe, B., Lindqvist, B. Swedish dental journal. (1981) [Pubmed]
  18. Late radiation effects to the rectum and bladder in gynecologic cancer patients: the comparison of LENT/SOMA and RTOG/EORTC late-effects scoring systems. Anacak, Y., Yalman, D., Ozsaran, Z., Haydaroğlu, A. Int. J. Radiat. Oncol. Biol. Phys. (2001) [Pubmed]
  19. Stimulant and relaxant drugs combined with stimulant and relaxant information: a study of active placebo. Flaten, M.A., Simonsen, T., Zahlsen, K., Aamo, T., Sager, G., Olsen, H. Psychopharmacology (Berl.) (2004) [Pubmed]
  20. What is the role of radiation in the treatment of subfoveal membranes: review of radiobiologic, pathologic, and other considerations to initiate a multimodality discussion. Archambeau, J.O., Mao, X.W., Yonemoto, L.T., Slater, J.D., Friedrichsen, E., Teichman, S., Preston, W., Slater, J.M. Int. J. Radiat. Oncol. Biol. Phys. (1998) [Pubmed]
  21. Increasing the rate of late toxicity by changing the score? A comparison of RTOG/EORTC and LENT/SOMA scores. Hoeller, U., Tribius, S., Kuhlmey, A., Grader, K., Fehlauer, F., Alberti, W. Int. J. Radiat. Oncol. Biol. Phys. (2003) [Pubmed]
  22. Evaluation of the LENT-SOMA scales for the prospective assessment of treatment morbidity in cervical carcinoma. Routledge, J.A., Burns, M.P., Swindell, R., Khoo, V.S., West, C.M., Davidson, S.E. Int. J. Radiat. Oncol. Biol. Phys. (2003) [Pubmed]
  23. A modified Inflammatory Bowel Disease questionnaire and the Vaizey Incontinence questionnaire are simple ways to identify patients with significant gastrointestinal symptoms after pelvic radiotherapy. Olopade, F.A., Norman, A., Blake, P., Dearnaley, D.P., Harrington, K.J., Khoo, V., Tait, D., Hackett, C., Andreyev, H.J. Br. J. Cancer (2005) [Pubmed]
  24. Radiation response of the central nervous system. Schultheiss, T.E., Kun, L.E., Ang, K.K., Stephens, L.C. Int. J. Radiat. Oncol. Biol. Phys. (1995) [Pubmed]
  25. Late toxicity results of the GORTEC 94-01 randomized trial comparing radiotherapy with concomitant radiochemotherapy for advanced-stage oropharynx carcinoma: comparison of LENT/SOMA, RTOG/EORTC, and NCI-CTC scoring systems. Denis, F., Garaud, P., Bardet, E., Alfonsi, M., Sire, C., Germain, T., Bergerot, P., Rhein, B., Tortochaux, J., Oudinot, P., Calais, G. Int. J. Radiat. Oncol. Biol. Phys. (2003) [Pubmed]
  26. Transfer of carisoprodol to breast milk. Nordeng, H., Zahlsen, K., Spigset, O. Therapeutic drug monitoring. (2001) [Pubmed]
  27. Risks of non-Hodgkin's lymphoma, multiple myeloma, and leukemia associated with common medications. Doody, M.M., Linet, M.S., Glass, A.G., Curtis, R.E., Pottern, L.M., Rush, B.B., Boice, J.D., Fraumeni, J.F., Friedman, G.D. Epidemiology (Cambridge, Mass.) (1996) [Pubmed]
  28. Behavioral effects of nonbenzodiazepine anxiolytic drugs: a comparison of CGS 9896 and zopiclone with chlordiazepoxide. Sanger, D.J., Joly, D., Zivkovic, B. J. Pharmacol. Exp. Ther. (1985) [Pubmed]
  29. Determination of meprobamate in serum by alkaline hydrolysis, trimethylsilyl derivatization and detection by gas chromatography-mass spectrometry. Stidman, J., Taylor, E.H., Simmons, H.F., Gandy, J., Pappas, A.A. J. Chromatogr. (1989) [Pubmed]
  30. Effect of a purified somatostatin monoclonal antibody and its Fab fragments on gastrin release. McIntosh, C.H., Tang, C.L., Malcolm, A.J., Ho, M., Kwok, Y.N., Brown, J.C. Am. J. Physiol. (1991) [Pubmed]
  31. The present status of meprobamate ingestion. A five-year review of cases with serum concentrations and clinical findings. Bailey, D.N. Am. J. Clin. Pathol. (1981) [Pubmed]
  32. The phylogeny of New World (Tacaribe complex) arenaviruses. Bowen, M.D., Peters, C.J., Nichol, S.T. Virology (1996) [Pubmed]
  33. Carisoprodol elimination in humans. Olsen, H., Koppang, E., Alvan, G., Mørland, J. Therapeutic drug monitoring. (1994) [Pubmed]
  34. Resin hemoperfusion for treatment of a massive meprobamate overdose. Hoy, W.E., Rivero, A., Marin, M.G., Rieders, F. Ann. Intern. Med. (1980) [Pubmed]
  35. Lack of correlation between residual radiation-induced DNA damage, in keratinocytes assayed directly from skin, and late radiotherapy reactions in breast cancer patients. Kiltie, A.E., Barber, J.B., Swindell, R., Ryan, A.J., West, C.M., Hendry, J.H., Magee, B. Int. J. Radiat. Oncol. Biol. Phys. (1999) [Pubmed]
  36. Carisoprodol: an unrecognized drug of abuse. Bailey, D.N., Briggs, J.R. Am. J. Clin. Pathol. (2002) [Pubmed]
  37. Determination of meprobamate as an n-butylboronate ester derivative in serum by gas-liquid chromatography. Johansson, B., Fromark, I. J. Chromatogr. (1985) [Pubmed]
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