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Gene Review

RIT1  -  Ras-like without CAAX 1

Homo sapiens

Synonyms: GTP-binding protein Rit1, MGC125864, MGC125865, NS8, RIBB, ...
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Disease relevance of RIT1

  • Immunogenicity and safety of live oral attenuated bovine rotavirus vaccine strain RIT 4237 in adults and young children [1].
  • We report the outcomes after reduced-intensity conditioning allogeneic stem cell transplantation (RIT) for non-Hodgkin lymphoma (NHL) in 88 patients (low-grade NHL [LG-NHL], n = 41; high-grade NHL [HG-NHL], n = 37; mantle cell lymphoma [MCL], n = 10) [2].
  • In the present study, we investigated the biochemical pathways by which C5b-9 generates AA from clone ROC-1, a fusion product of rat oligodendrocytes and C6 glioma [3].
  • GSK-MMR (Priorix) is a trivalent live attenuated measles, mumps and rubella (MMR) vaccine which contains the Schwarz measles, the RIT 4385 mumps (derived from the Jeryl Lynn mumps strain) and the Wistar RA 27/3 rubella strains [4].
  • Cell swelling, blebbing, and death are dependent on ATP depletion and independent of calcium during chemical hypoxia in a glial cell line (ROC-1) [5].

High impact information on RIT1


Chemical compound and disease context of RIT1

  • There were no significant increases in lactate dehydrogenase activity in N1E-115 neuroblastoma or ROC-1 oligodendroglial cells [9].

Biological context of RIT1

  • Furthermore, endogenous levels of pro-caspase-3 were decreased by overexpression of SAG/ROC-SCF(beta-TrCP) E3 Ub ligases, but increased on siRNA silencing of SAG, regulator of cullin-1 (ROC1), or beta-TrCPs, leading to increased apoptosis by etoposide and TNF-related apoptosis-inducing ligand through increased activation of caspase-3 [10].
  • Antibody response, indicating infection with the vaccine virus, was detected in 21 (88%) of 24 children receiving the RRV-1 vaccine and in 18 (75%) of 24 receiving the RIT 4237 vaccine [11].
  • These results suggest that osmotic cell swelling may be a contributing factor in the loss of cell viability when ROC-1 cells are depleted of ATP [8].
  • Oligodendroglia-glioma hybrid cells (ROC-1) subjected to inhibition of glycolytic and oxidative ATP synthesis undergo a sequence of changes, including ATP depletion, parallel processes of cell swelling and blebbing, and finally plasma membrane disruption and cell death [8].
  • It was found to be associated with domain haplotypes I (RIT) and 4 (RVR) and with the presence and absence of the Alu insertion [12].

Anatomical context of RIT1

  • Oligodendroglial-glioma hybrid cells (ROC-1) were subjected to inhibitors of glycolytic and oxidative ATP synthesis (chemical hypoxia) [5].
  • RIT is a promising new therapy that should be incorporated into the management of patients with B-cell non-Hodgkin's lymphoma (NHL) soon after these patients have proven incurable [13].
  • To assess the cytotoxicity of four clays containing an aluminum silicate--montmorillonite, bentonite, kaolinite and erionite--we used human umbilical vein endothelial, N1E-115 neuroblastoma, and ROC-1 oligodendroglial cells [9].
  • In some countries with a limited number of specialized hospital beds for radionuclide therapy, ablation therapy (RIT) of differentiated thyroid carcinoma (DTC) is performed using a fractionated dosage of radioiodine [14].
  • We developed two markers specifically staining the L2 and L3 layers (OsSCR and OsPNH1, respectively) and characterized the gle mutants by using these markers in addition to the already developed markers Roc1 (marker for the L1 layer), Ramy1A (marker of the L1 layer of the epithelium), and OSH1 (marker of the apical region) [15].

Associations of RIT1 with chemical compounds

  • Therapy was zidovudine/lamivudine 1 pill twice daily plus IND/RIT (liquid formulation) 800/100 mg twice daily with food [16].
  • Additionally, radiotracer ((65)Zn, (109)Cd) flux techniques were used to show that RIT can also mediate a lower affinity Zn and Cd influx ( K(m) of 4 and 100 microM, for Zn(2+) and Cd(2+), respectively) [17].
  • Ten obese women and 10 normal-weight control women underwent three IIH tests, at 14-day intervals: the first in basal conditions, the other two after randomized administration of a serotoninergic drug, fenfluramine (FF, 120 mg/day for 7 days) and FF plus ritanserin (RIT, 30 mg/day for the first 2 days and 20 mg/day on the following days) [18].
  • The activity of ALT and RIT in CLL patients resistant to FA and their synergistic interactions with cytotoxic drugs suggests that a combination of these agents may lead to further progress in the treatment of this disease [19].
  • In this study, a lithium-ion (Li+) secondary battery was used as the RIBB [20].

Analytical, diagnostic and therapeutic context of RIT1

  • Alemtuzumab concentrations in RIT patients were in excess of that required to kill infused donor CD52+ cells at the time of transplantation and remained at potentially lympholytic levels (> 0.1 microg/mL) for approximately 56 days after transplantation, 26 days longer than for the myeloablative group [6].
  • Excretion of virus in the stools within one week after vaccination was demonstrable in 84% of the RRV-1 and in 21% of the RIT 4237 vaccinees [11].
  • The fractionation of human serum proteins using capillary isotachophoresis (CITP) and recycling isotachophoresis (RITP) in presence of low molecular mass spacer compounds is reported [21].
  • Together with U36 and BIWA-1, these new antibodies were evaluated for affinity to the antigen in vitro as well as for biodistribution and efficacy in RIT using nude mice bearing the HNSCC xenograft line HNX-OE [22].
  • Omission of the first step (RITP) and direct processing of dialyzed serum by RIEF-OptiFocus, ultrafiltration and RITP, is shown to provide remarkable results as well [23].


  1. Immunogenicity and safety of live oral attenuated bovine rotavirus vaccine strain RIT 4237 in adults and young children. Vesikari, T., Isolauri, E., Delem, A., D'Hondt, E., André, F.E., Zissis, G. Lancet (1983) [Pubmed]
  2. Outcomes after alemtuzumab-containing reduced-intensity allogeneic transplantation regimen for relapsed and refractory non-Hodgkin lymphoma. Morris, E., Thomson, K., Craddock, C., Mahendra, P., Milligan, D., Cook, G., Smith, G.M., Parker, A., Schey, S., Chopra, R., Hatton, C., Tighe, J., Hunter, A., Peggs, K., Linch, D., Goldstone, A., Mackinnon, S. Blood (2004) [Pubmed]
  3. Arachidonic acid mobilization and phosphoinositide turnover by the terminal complement complex, C5b-9, in rat oligodendrocyte x C6 glioma cell hybrids. Shirazi, Y., McMorris, F.A., Shin, M.L. J. Immunol. (1989) [Pubmed]
  4. Measles, mumps, rubella vaccine (Priorix; GSK-MMR): a review of its use in the prevention of measles, mumps and rubella. Wellington, K., Goa, K.L. Drugs (2003) [Pubmed]
  5. Cell swelling, blebbing, and death are dependent on ATP depletion and independent of calcium during chemical hypoxia in a glial cell line (ROC-1). Jurkowitz-Alexander, M.S., Altschuld, R.A., Hohl, C.M., Johnson, J.D., McDonald, J.S., Simmons, T.D., Horrocks, L.A. J. Neurochem. (1992) [Pubmed]
  6. Pharmacokinetics of alemtuzumab used for in vivo and in vitro T-cell depletion in allogeneic transplantations: relevance for early adoptive immunotherapy and infectious complications. Morris, E.C., Rebello, P., Thomson, K.J., Peggs, K.S., Kyriakou, C., Goldstone, A.H., Mackinnon, S., Hale, G. Blood (2003) [Pubmed]
  7. Enantiomeric separation of methadone by cyclodextrin-based capillary and recycling isotachophoresis. Lanz, M., Caslavska, J., Thormann, W. Electrophoresis (1998) [Pubmed]
  8. Protection of ROC-1 hybrid glial cells by polyethylene glycol following ATP depletion. Jurkowitz-Alexander, M.S., Altschuld, R.A., Haun, S.E., Stephens, R.E., Horrocks, L.A. J. Neurochem. (1993) [Pubmed]
  9. Aluminum silicate toxicity in cell cultures. Murphy, E.J., Roberts, E., Horrocks, L.A. Neuroscience (1993) [Pubmed]
  10. SAG/ROC-SCFbeta-TrCP E3 ubiquitin ligase promotes pro-caspase-3 degradation as a mechanism of apoptosis protection. Tan, M., Gallegos, J.R., Gu, Q., Huang, Y., Li, J., Jin, Y., Lu, H., Sun, Y. Neoplasia (2006) [Pubmed]
  11. A comparative trial of rhesus monkey (RRV-1) and bovine (RIT 4237) oral rotavirus vaccines in young children. Vesikari, T., Kapikian, A.Z., Delem, A., Zissis, G. J. Infect. Dis. (1986) [Pubmed]
  12. Association of the alpha-spectrin R28H mutation with allele alphaLELY and with alphaI/alphaII domain haplotypes in three Brazilian families. Bassères, D.S., Bordin, S., Costa, F.F., Saad, S.T. Eur. J. Haematol. (2000) [Pubmed]
  13. Cure of incurable lymphoma. Denardo, G.L., Sysko, V.V., Denardo, S.J. Int. J. Radiat. Oncol. Biol. Phys. (2006) [Pubmed]
  14. Fractionated dosage of radioiodine for the ablation of differentiated thyroid carcinoma. Czepczyński, R., Ziemnicka, K., Baczyk, M., Oleksa, R., Ruchała, M., Sowiński, J. Thyroid (2005) [Pubmed]
  15. Rice globular embryo 4 (gle4) mutant is defective in radial pattern formation during embryogenesis. Kamiya, N., Nishimura, A., Sentoku, N., Takabe, E., Nagato, Y., Kitano, H., Matsuoka, M. Plant Cell Physiol. (2003) [Pubmed]
  16. Dose-finding study of once-daily indinavir/ritonavir plus zidovudine and lamivudine in HIV-infected patients. Mallolas, J., Blanco, J.L., Sarasa, M., Giner, V., Martínez, E., García-Viejo, M.A., Arnaiz, J.A., Cruceta, A., Soy, D., Tuset, M., Soriano, A., Codina, C., Pumarola, T., Carné, X., Gatell, J.M. J. Acquir. Immune Defic. Syndr. (2000) [Pubmed]
  17. Kinetic properties of a micronutrient transporter from Pisum sativum indicate a primary function in Fe uptake from the soil. Cohen, C.K., Garvin, D.F., Kochian, L.V. Planta (2004) [Pubmed]
  18. Impaired growth hormone response to insulin-induced hypoglycaemia in obese patients: restoration blocked by ritanserin after fenfluramine administration. Bernini, G.P., Argenio, G.F., Vivaldi, M.S., Del Corso, C., Birindelli, R., Luisi, M., Franchi, F. Clin. Endocrinol. (Oxf) (1990) [Pubmed]
  19. Monoclonal antibodies in the treatment of chronic lymphoid leukemias. Robak, T. Leuk. Lymphoma (2004) [Pubmed]
  20. A transcutaneous energy transmission system with rechargeable internal back-up battery for a totally implantable total artificial heart. Shiba, K., Shu, E., Koshiji, K., Tsukahara, K., Nakamura, T., Masuzawa, T., Tatsumi, E., Taenaka, Y., Takano, H. ASAIO journal (American Society for Artificial Internal Organs : 1992) (1999) [Pubmed]
  21. Fractionation of human serum proteins by capillary and recycling isotachophoresis. Caslavska, J., Gebauer, P., Thormann, W. Electrophoresis (1994) [Pubmed]
  22. Tumor targeting properties of monoclonal antibodies with different affinity for target antigen CD44V6 in nude mice bearing head-and-neck cancer xenografts. Verel, I., Heider, K.H., Siegmund, M., Ostermann, E., Patzelt, E., Sproll, M., Snow, G.B., Adolf, G.R., van Dongen, G.A. Int. J. Cancer (2002) [Pubmed]
  23. Isolation of human serum transferrin by free-fluid recycling electrophoresis in simple buffers. Caslavska, J., Thormann, W. Electrophoresis (1994) [Pubmed]
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