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Gene Review

Aqp9  -  aquaporin 9

Rattus norvegicus

Synonyms: AQP-9, Aquaglyceroporin-9, Aquaporin-9
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Disease relevance of Aqp9

  • We hypothesize that the complement of mitochondrial AQP9 in dopaminergic neurons may relate to the vulnerability of these neurons in Parkinson's disease [1].

High impact information on Aqp9


Biological context of Aqp9


Anatomical context of Aqp9


Associations of Aqp9 with chemical compounds

  • Interestingly, progesterone administration after progesterone priming also induced AQP9 expression but without a change in mRNA levels [5].
  • The recovery of AQP9 reactivity after ovariectomy correlated with increased mRNA and protein levels after treatment with estradiol alone or progesterone administration after estradiol priming [5].
  • These results indicate that steroid hormones regulate AQP9 expression at the mRNA and protein level and that other ovarian signals are involved in the expression of AQP5 and -8 [5].
  • DHT (5alpha-dihydrotestosterone) also modulated AQP9 in efferent ductules [10].
  • In addition, castrated adult rats showed lower levels of epididymal AQP9 compared with adult controls, whereas systemic testosterone treatment of castrated adult rats induced a recovery of the expression of AQP9 to control levels [11].

Other interactions of Aqp9


Analytical, diagnostic and therapeutic context of Aqp9


  1. Brain mitochondria contain aquaporin water channels: evidence for the expression of a short AQP9 isoform in the inner mitochondrial membrane. Amiry-Moghaddam, M., Lindland, H., Zelenin, S., Roberg, B.A., Gundersen, B.B., Petersen, P., Rinvik, E., Torgner, I.A., Ottersen, O.P. FASEB J. (2005) [Pubmed]
  2. Isolation and characterization of lipid microdomains from apical and basolateral plasma membranes of rat hepatocytes. Mazzone, A., Tietz, P., Jefferson, J., Pagano, R., LaRusso, N.F. Hepatology (2006) [Pubmed]
  3. Expression and localization of aquaporin water channels in rat hepatocytes. Evidence for a role in canalicular bile secretion. Huebert, R.C., Splinter, P.L., Garcia, F., Marinelli, R.A., LaRusso, N.F. J. Biol. Chem. (2002) [Pubmed]
  4. Postnatal expression of aquaporins in epithelial cells of the rat epididymis. Da Silva, N., Silberstein, C., Beaulieu, V., Piétrement, C., Van Hoek, A.N., Brown, D., Breton, S. Biol. Reprod. (2006) [Pubmed]
  5. Regulation of the immunoexpression of aquaporin 9 by ovarian hormones in the rat oviductal epithelium. Brañes, M.C., Morales, B., Ríos, M., Villalón, M.J. Am. J. Physiol., Cell Physiol. (2005) [Pubmed]
  6. Water permeability in rat oocytes at different maturity stages: aquaporin-9 expression. Ford, P., Merot, J., Jawerbaum, A., Gimeno, M.A., Capurro, C., Parisi, M. J. Membr. Biol. (2000) [Pubmed]
  7. Differential regulation of aquaporin-5 and -9 expression in astrocytes by protein kinase A. Yamamoto, N., Sobue, K., Fujita, M., Katsuya, H., Asai, K. Brain Res. Mol. Brain Res. (2002) [Pubmed]
  8. Tissue distribution and membrane localization of aquaporin-9 water channel: evidence for sex-linked differences in liver. Nicchia, G.P., Frigeri, A., Nico, B., Ribatti, D., Svelto, M. J. Histochem. Cytochem. (2001) [Pubmed]
  9. Analysis of the expression of aquaporin-1 and aquaporin-9 in pig liver tissue: comparison with rat liver tissue. Talbot, N.C., Garrett, W.M., Caperna, T.J. Cells Tissues Organs (Print) (2003) [Pubmed]
  10. Aquaporin-1 and -9 are differentially regulated by oestrogen in the efferent ductule epithelium and initial segment of the epididymis. Oliveira, C.A., Carnes, K., França, L.R., Hermo, L., Hess, R.A. Biol. Cell (2005) [Pubmed]
  11. Expression of aquaporin 9 in the adult rat epididymal epithelium is modulated by androgens. Pastor-Soler, N., Isnard-Bagnis, C., Herak-Kramberger, C., Sabolic, I., Van Hoek, A., Brown, D., Breton, S. Biol. Reprod. (2002) [Pubmed]
  12. Radioimmunoassay for aquaporin-9. Li, C., Hirooka, Y., Yasaka, T., Takagi, J., Gotoh, M., Nogimori, T. Endocrine regulations. (2004) [Pubmed]
  13. Distribution of aquaporin-9 in the rat: an immunohistochemical study. Li, C., Hirooka, Y., Honda, R., Morikawa, R., Yatoh, M., Gotoh, M., Nogimori, T. International journal of tissue reactions. (2005) [Pubmed]
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