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Gene Review

Aqp9  -  aquaporin 9

Mus musculus

Synonyms: 1700020I22Rik, AI266899, AQP-9, Aquaglyceroporin-9, Aquaporin-9
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Disease relevance of Aqp9


High impact information on Aqp9

  • Introduction of a plasmid containing AQP9 reverses the metalloid tolerance of the deletion strain [4].
  • Xenopus laevis oocytes microinjected with either AQP7 or AQP9 cRNA exhibited increased transport of (73)As(III) [4].
  • Arsenite transport by mammalian aquaglyceroporins AQP7 and AQP9 [4].
  • Involvement of aquaporin 9 in osteoclast differentiation [5].
  • Our results indicate that coordinated regulations of fat-specific AQPap/7 and liver-specific AQP9 should be crucial to determine glucose metabolism in physiology and insulin resistance [1].

Biological context of Aqp9


Anatomical context of Aqp9


Associations of Aqp9 with chemical compounds

  • These changes in hepatic AQP9 mRNA were accompanied by those of hepatic gluconeogenic mRNAs and plasma glycerol levels [1].
  • Insulin deficiency induced by streptozotocin resulted in increased hepatic AQP9 mRNA [1].
  • Finally, we examined the effect of phloretin, an AQP9 inhibitor, on RANKL-induced osteoclast differentiation [5].
  • Aquaporin-9 (AQP9) is a new member of the aquaporin family of water-selective channels mainly expressed in liver and testis, presenting the characteristic of also being permeable to various solutes, particularly lactate [2].

Other interactions of Aqp9

  • Light microscope immunolocalizations of AQP-1 and AQP-9 revealed dramatic reduction and patchier staining in alphaERKO mice with distal areas of the efferent ductules being more affected than proximal areas [12].

Analytical, diagnostic and therapeutic context of Aqp9


  1. Coordinated regulation of fat-specific and liver-specific glycerol channels, aquaporin adipose and aquaporin 9. Kuriyama, H., Shimomura, I., Kishida, K., Kondo, H., Furuyama, N., Nishizawa, H., Maeda, N., Matsuda, M., Nagaretani, H., Kihara, S., Nakamura, T., Tochino, Y., Funahashi, T., Matsuzawa, Y. Diabetes (2002) [Pubmed]
  2. Astrocyte-specific expression of aquaporin-9 in mouse brain is increased after transient focal cerebral ischemia. Badaut, J., Hirt, L., Granziera, C., Bogousslavsky, J., Magistretti, P.J., Regli, L. J. Cereb. Blood Flow Metab. (2001) [Pubmed]
  3. Time course of aquaporin expression after transient focal cerebral ischemia in mice. de Castro Ribeiro, M., Hirt, L., Bogousslavsky, J., Regli, L., Badaut, J. J. Neurosci. Res. (2006) [Pubmed]
  4. Arsenite transport by mammalian aquaglyceroporins AQP7 and AQP9. Liu, Z., Shen, J., Carbrey, J.M., Mukhopadhyay, R., Agre, P., Rosen, B.P. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  5. Involvement of aquaporin 9 in osteoclast differentiation. Aharon, R., Bar-Shavit, Z. J. Biol. Chem. (2006) [Pubmed]
  6. Role of aquaporin-7 in the pathophysiological control of fat accumulation in mice. Rodríguez, A., Catalán, V., Gómez-Ambrosi, J., Frühbeck, G. FEBS Lett. (2006) [Pubmed]
  7. Functional challenge affects aquaporin mRNA abundance in mouse blastocysts. Offenberg, H., Thomsen, P.D. Mol. Reprod. Dev. (2005) [Pubmed]
  8. Aquaporin proteins in murine trophectoderm mediate transepithelial water movements during cavitation. Barcroft, L.C., Offenberg, H., Thomsen, P., Watson, A.J. Dev. Biol. (2003) [Pubmed]
  9. Aquaporin water channel genes are differentially expressed and regulated by ovarian steroids during the periimplantation period in the mouse. Richard, C., Gao, J., Brown, N., Reese, J. Endocrinology (2003) [Pubmed]
  10. Expression of aquaporin water channels in mouse spinal cord. Oshio, K., Binder, D.K., Yang, B., Schecter, S., Verkman, A.S., Manley, G.T. Neuroscience (2004) [Pubmed]
  11. Aquaporin-9 is expressed in a mucus-secreting goblet cell subset in the small intestine. Okada, S., Misaka, T., Matsumoto, I., Watanabe, H., Abe, K. FEBS Lett. (2003) [Pubmed]
  12. Expression of aquaporins in the efferent ductules, sperm counts, and sperm motility in estrogen receptor-alpha deficient mice fed lab chow versus casein. Ruz, R., Gregory, M., Smith, C.E., Cyr, D.G., Lubahn, D.B., Hess, R.A., Hermo, L. Mol. Reprod. Dev. (2006) [Pubmed]
  13. Immunolocalization of AQP9 in liver, epididymis, testis, spleen, and brain. Elkjaer, M., Vajda, Z., Nejsum, L.N., Kwon, T., Jensen, U.B., Amiry-Moghaddam, M., Frøkiaer, J., Nielsen, S. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
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