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Gene Review

TARBP2  -  TAR (HIV-1) RNA binding protein 2

Homo sapiens

Synonyms: LOQS, RISC-loading complex subunit TARBP2, TAR RNA-binding protein 2, TRBP, TRBP1, ...
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Disease relevance of TARBP2


High impact information on TARBP2

  • Here we show that RISC is composed of Dicer, the double-stranded RNA binding protein TRBP, and Argonaute2 [6].
  • In intracellular and in cell-free assays we show that TRBP directly inhibits PKR autophosphorylation through an RNA binding-independent pathway [7].
  • Biologically, TRBP serves a growth-promoting role; cells that overexpress TRBP exhibit transformed phenotypes [7].
  • Our results demonstrate the oncogenic potential of TRBP and are consistent with the notion that intracellular PKR function contributes physiologically towards regulating cellular proliferation [7].
  • In transfection assays, TRBP has also been shown to inhibit the interferon-induced protein kinase PKR possibly by direct physical interaction [8].

Biological context of TARBP2


Anatomical context of TARBP2


Associations of TARBP2 with chemical compounds

  • Merlin efficiently inhibited these oncogenic activities of TRBP in our experiments [9].

Physical interactions of TARBP2


Regulatory relationships of TARBP2


Other interactions of TARBP2

  • The expression of both CycT1 and TRBP2 had a more than additive activity on RT function in cell extracts and on viral particle production in supernatant of murine cells [16].
  • TRBP promoters are TATA-less but have CCAAT boxes, a CpG island, and several potential binding sites for transcriptional factors [11].
  • TAR RNA-binding protein, TRBP, was recently discovered to be an essential partner for Dicer and a crucial component of the RNA-induced silencing complex (RISC), a critical element of the RNA interference (RNAi) of the cell apparatus [17].
  • In the human embryonic kidney 293 cell line, the level of endogenous merlin increased, whereas that of endogenous TRBP significantly decreased along with the increase in cell confluence [15].

Analytical, diagnostic and therapeutic context of TARBP2


  1. A Role of RNA Helicase A in cis-Acting Transactivation Response Element-mediated Transcriptional Regulation of Human Immunodeficiency Virus Type 1. Fujii, R., Okamoto, M., Aratani, S., Oishi, T., Ohshima, T., Taira, K., Baba, M., Fukamizu, A., Nakajima, T. J. Biol. Chem. (2001) [Pubmed]
  2. Cell-specific regulation of TRBP1 promoter by NF-Y transcription factor in lymphocytes and astrocytes. Bannwarth, S., Lainé, S., Daher, A., Grandvaux, N., Clerzius, G., Leblanc, A.C., Hiscott, J., Gatignol, A. J. Mol. Biol. (2006) [Pubmed]
  3. Characterization of TRBP1 and TRBP2. Stable stem-loop structure at the 5' end of TRBP2 mRNA resembles HIV-1 TAR and is not found in its processed pseudogene. Duarte, M., Graham, K., Daher, A., Battisti, P.L., Bannwarth, S., Segeral, E., Jeang, K.T., Gatignol, A. J. Biomed. Sci. (2000) [Pubmed]
  4. Identification and requirement of three ribosome binding domains in dsRNA-dependent protein kinase (PKR). Wu, S., Kumar, K.U., Kaufman, R.J. Biochemistry (1998) [Pubmed]
  5. Sp1 binds to the precise locus of end processing within the terminal repeats of Epstein-Barr virus DNA. Sun, R., Spain, T.A., Lin, S.F., Miller, G. J. Virol. (1997) [Pubmed]
  6. Human RISC couples microRNA biogenesis and posttranscriptional gene silencing. Gregory, R.I., Chendrimada, T.P., Cooch, N., Shiekhattar, R. Cell (2005) [Pubmed]
  7. Oncogenic potential of TAR RNA binding protein TRBP and its regulatory interaction with RNA-dependent protein kinase PKR. Benkirane, M., Neuveut, C., Chun, R.F., Smith, S.M., Samuel, C.E., Gatignol, A., Jeang, K.T. EMBO J. (1997) [Pubmed]
  8. Xlrbpa, a double-stranded RNA-binding protein associated with ribosomes and heterogeneous nuclear RNPs. Eckmann, C.R., Jantsch, M.F. J. Cell Biol. (1997) [Pubmed]
  9. Merlin, a tumor suppressor, interacts with transactivation-responsive RNA-binding protein and inhibits its oncogenic activity. Lee, J.Y., Kim, H., Ryu, C.H., Kim, J.Y., Choi, B.H., Lim, Y., Huh, P.W., Kim, Y.H., Lee, K.H., Jun, T.Y., Rha, H.K., Kang, J.K., Choi, C.R. J. Biol. Chem. (2004) [Pubmed]
  10. Relatedness of an RNA-binding motif in human immunodeficiency virus type 1 TAR RNA-binding protein TRBP to human P1/dsI kinase and Drosophila staufen. Gatignol, A., Buckler, C., Jeang, K.T. Mol. Cell. Biol. (1993) [Pubmed]
  11. Organization of the human tarbp2 gene reveals two promoters that are repressed in an astrocytic cell line. Bannwarth, S., Talakoub, L., Letourneur, F., Duarte, M., Purcell, D.F., Hiscott, J., Gatignol, A. J. Biol. Chem. (2001) [Pubmed]
  12. Two dimerization domains in the trans-activation response RNA-binding protein (TRBP) individually reverse the protein kinase R inhibition of HIV-1 long terminal repeat expression. Daher, A., Longuet, M., Dorin, D., Bois, F., Segeral, E., Bannwarth, S., Battisti, P.L., Purcell, D.F., Benarous, R., Vaquero, C., Meurs, E.F., Gatignol, A. J. Biol. Chem. (2001) [Pubmed]
  13. TRBP, a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing. Haase, A.D., Jaskiewicz, L., Zhang, H., Lainé, S., Sack, R., Gatignol, A., Filipowicz, W. EMBO Rep. (2005) [Pubmed]
  14. Expression of the TAR RNA binding protein in human testis. Siffroi, J.P., Pawlak, A., Alfonsi, M.F., Troalen, F., Guellaen, G., Dadoune, J.P. Mol. Hum. Reprod. (2001) [Pubmed]
  15. Merlin facilitates ubiquitination and degradation of transactivation-responsive RNA-binding protein. Lee, J.Y., Moon, H.J., Lee, W.K., Chun, H.J., Han, C.W., Jeon, Y.W., Lim, Y., Kim, Y.H., Yao, T.P., Lee, K.H., Jun, T.Y., Rha, H.K., Kang, J.K. Oncogene (2006) [Pubmed]
  16. Additive activity between the trans-activation response RNA-binding protein, TRBP2, and cyclin T1 on HIV type 1 expression and viral production in murine cells. Battisti, P.L., Daher, A., Bannwarth, S., Voortman, J., Peden, K.W., Hiscott, J., Mouland, A.J., Benarous, R., Gatignol, A. AIDS Res. Hum. Retroviruses (2003) [Pubmed]
  17. HIV-1 TAR RNA Subverts RNA Interference in Transfected Cells through Sequestration of TAR RNA-binding Protein, TRBP. Bennasser, Y., Yeung, M.L., Jeang, K.T. J. Biol. Chem. (2006) [Pubmed]
  18. Genetic mapping in human and mouse of the locus encoding TRBP, a protein that binds the TAR region of the human immunodeficiency virus (HIV-1). Kozak, C.A., Gatignol, A., Graham, K., Jeang, K.T., McBride, O.W. Genomics (1995) [Pubmed]
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