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Gene Review

F13a1  -  coagulation factor XIII, A1 subunit

Mus musculus

Synonyms: 1200014I03Rik, AI462306, Coagulation factor XIII A chain, Coagulation factor XIIIa, F13a, ...
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Disease relevance of F13a1


High impact information on F13a1


Biological context of F13a1


Anatomical context of F13a1

  • We revealed the expression of FXIIIA in the epiphyseal growth plate, where FXIIIA appears first intracellularly in the zone of proliferation/maturation, and remains intra- and extracellularly throughout the hypertrophic zone [7].
  • We conclude, that coagulation factor FXIIIA is expressed by chondrocytes of embryonic mouse long bone cartilages in a strictly regulated pattern, which correlates with chondrocyte differentiation and matrix mineralization [7].
  • At day 7 post-BLM, 48% of CD11b+ BAMC displayed features of DC differentiation, as judged by dendritic morphology, expression of class II MHC, 33D1, Factor XIIIa, CD80, and CD86 antigens, and the ability to support a primary allogeneic lymphocyte response (MLR) [8].
  • Double-labelling experiments showed that a proportion (approximately 20%) of PKC-beta+ dendritic cells also expressed factor XIIIa [9].
  • Expression of the A subunit of factor XIII is restricted to megakaryocytes in the bone marrow cavity, and factor XIIIa is abundant in platelets that probably provide the major source for factor XIII in plasma [10].

Associations of F13a1 with chemical compounds


Analytical, diagnostic and therapeutic context of F13a1


  1. 12E2: a cloned murine dermal cell with features of dermal dendrocytes and capacity to produce pathologic changes resembling early Kaposi's sarcoma. Deguchi, M., Whitaker-Menezes, D., Jones, S.C., Aiba, S., Nakagawa, S., Tagami, H., Korngold, R., Murphy, G.F. Am. J. Pathol. (2003) [Pubmed]
  2. Molecular imaging of factor XIIIa activity in thrombosis using a novel, near-infrared fluorescent contrast agent that covalently links to thrombi. Jaffer, F.A., Tung, C.H., Wykrzykowska, J.J., Ho, N.H., Houng, A.K., Reed, G.L., Weissleder, R. Circulation (2004) [Pubmed]
  3. Fibronectin (cold-insoluble globulin): role in defence. Vaheri, A. Schweizerische medizinische Wochenschrift. (1980) [Pubmed]
  4. Factor XIIIA transglutaminase crosslinks AT1 receptor dimers of monocytes at the onset of atherosclerosis. AbdAlla, S., Lother, H., Langer, A., el Faramawy, Y., Quitterer, U. Cell (2004) [Pubmed]
  5. Covalent cross-linking of fibronectin to fibrin is required for maximal cell adhesion to a fibronectin-fibrin matrix. Corbett, S.A., Lee, L., Wilson, C.L., Schwarzbauer, J.E. J. Biol. Chem. (1997) [Pubmed]
  6. Analysis of the catalytic activity of human factor XIIIa by site-directed mutagenesis. Hettasch, J.M., Greenberg, C.S. J. Biol. Chem. (1994) [Pubmed]
  7. Immunohistological analysis of transglutaminase factor XIIIA expression in mouse embryonic growth plate. Nurminskaya, M.V., Linsenmayer, T.F. J. Orthop. Res. (2002) [Pubmed]
  8. Accessory cells with immunophenotypic and functional features of monocyte-derived dendritic cells are recruited to the lung during pulmonary inflammation. Tager, A.M., Luster, A.D., Leary, C.P., Sakamoto, H., Zhao, L.H., Preffer, F., Kradin, R.L. J. Leukoc. Biol. (1999) [Pubmed]
  9. Overexpression of protein kinase C-alpha and -beta isozymes by stromal dendritic cells in basal and squamous cell carcinoma. Reynolds, N.J., Todd, C., Angus, B. Br. J. Dermatol. (1997) [Pubmed]
  10. Tissue transglutaminase and factor XIII in cartilage and bone remodeling. Aeschlimann, D., Mosher, D., Paulsson, M. Semin. Thromb. Hemost. (1996) [Pubmed]
  11. Propolypeptide of von Willebrand factor serves as a substrate for factor XIIIa and is cross-linked to laminin. Usui, T., Takagi, J., Saito, Y. J. Biol. Chem. (1993) [Pubmed]
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