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Chemical Compound Review

SureCN107806     N-(5-aminopentyl)-5- dimethylamino...

Synonyms: AG-J-88313, D4008_SIGMA, AC1L1HQJ, AC1Q6ULC, CTK8F8945, ...
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Disease relevance of monodansylcadaverine


High impact information on monodansylcadaverine

  • Therefore, we studied the temporo-spatial expression of transglutaminase activity in skin regenerating from cultured epithelial autografts in severely burned children by the specific incorporation of monodansylcadaverine into cryostat sections from skin biopsies obtained between 5 d to 17 mo after grafting [6].
  • Moreover, monodansylcadaverine, a competitive inhibitor of transglutaminase, reversibly inhibited the myofibril maturation [7].
  • Inhibition of tTGase activity by either the tTGase inhibitor monodansylcadaverine or short-hairpin RNA reduces the cross-linked species p40 and p64 and restores caspase 3 activation in response to THG treatment [8].
  • Here, we demonstrate that MPP(+) elicited increased autophagy in SH-SY5Y cells, as assessed by electron microscopy, immunofluorescence for the autophagy protein LC3/Atg8, LC3 electrophoretic mobility shift, mitochondrial degradation, and monodansylcadaverine staining for late AVs/autolysosomes [9].
  • Moreover, cell viability assays showed that incubation of RA-treated cells with LY294002 together with the TGase inhibitor, monodansylcadaverine (MDC), converted RA from a differentiation factor to an apoptotic stimulus [10].

Chemical compound and disease context of monodansylcadaverine

  • We have examined the interaction of the host autophagic pathway with Chlamydia trachomatis serovar L2 by using the specific autophagosomal stain monodansylcadaverine, antibodies to autophagosome-associated markers, and traditionally used autophagic inhibitors, particularly 3-methyladenine and amino acids [11].

Biological context of monodansylcadaverine


Anatomical context of monodansylcadaverine


Associations of monodansylcadaverine with other chemical compounds


Gene context of monodansylcadaverine

  • Inhibition of receptor internalization by monodansylcadaverine selectively blocks p55 tumor necrosis factor receptor death domain signaling [22].
  • Staining with the autophagosome-specific fluorescent dye monodansylcadaverine revealed that, unlike wild-type plants, AtATG18a RNA interference plants are unable to produce autophagosomes in response to starvation or senescence conditions [27].
  • Simultaneous inhibition of intracellular and extracellular TGase activity by monodansylcadaverine (MDC) strongly weakened barrier properties of MyEnd monolayers, whereas inhibition of extracellular TGases by the membrane-impermeable active site-directed TGase inhibitor R281 did not reduce barrier properties [28].
  • The glutamine-3 residue near the amino terminus of each chain was labeled enzymatically with either monodansylcadaverine or monofluoresceinylcadaverine by use of coagulation factor XIIIa [29].
  • Pretreatment with the TG2 inhibitor monodansylcadaverine (MDC) greatly increased EGF-induced DNA synthesis in both PPH and PVH [30].

Analytical, diagnostic and therapeutic context of monodansylcadaverine


  1. Inhibition of the nuclear entry of 3,3',5'-triiodo-L-thyronine by monodansylcadaverine in GH3 cells. Horiuchi, R., Cheng, S.Y., Willingham, M., Pastan, I. J. Biol. Chem. (1982) [Pubmed]
  2. Effect of methylamine and monodansylcadaverine on the susceptibility of McCoy cells to Chlamydia trachomatis infection. Söderlund, G., Kihlström, E. Infect. Immun. (1983) [Pubmed]
  3. Inhibition of infection of macrophages with Ehrlichia risticii by cytochalasins, monodansylcadaverine, and taxol. Rikihisa, Y., Zhang, Y., Park, J. Infect. Immun. (1994) [Pubmed]
  4. Intracellular infection by the human granulocytic ehrlichiosis agent inhibits human neutrophil apoptosis. Yoshiie, K., Kim, H.Y., Mott, J., Rikihisa, Y. Infect. Immun. (2000) [Pubmed]
  5. Signaling pathways initiated in macrophages after engagement of type A scavenger receptors. Coller, S.P., Paulnock, D.M. J. Leukoc. Biol. (2001) [Pubmed]
  6. Cross-linking of the dermo-epidermal junction of skin regenerating from keratinocyte autografts. Anchoring fibrils are a target for tissue transglutaminase. Raghunath, M., Höpfner, B., Aeschlimann, D., Lüthi, U., Meuli, M., Altermatt, S., Gobet, R., Bruckner-Tuderman, L., Steinmann, B. J. Clin. Invest. (1996) [Pubmed]
  7. Involvement of transglutaminase in myofibril assembly of chick embryonic myoblasts in culture. Kang, S.J., Shin, K.S., Song, W.K., Ha, D.B., Chung, C.H., Kang, M.S. J. Cell Biol. (1995) [Pubmed]
  8. Tissue transglutaminase serves as an inhibitor of apoptosis by cross-linking caspase 3 in thapsigargin-treated cells. Yamaguchi, H., Wang, H.G. Mol. Cell. Biol. (2006) [Pubmed]
  9. Regulation of autophagy by extracellular signal-regulated protein kinases during 1-methyl-4-phenylpyridinium-induced cell death. Zhu, J.H., Horbinski, C., Guo, F., Watkins, S., Uchiyama, Y., Chu, C.T. Am. J. Pathol. (2007) [Pubmed]
  10. Phosphoinositide 3-kinase activity is required for retinoic acid-induced expression and activation of the tissue transglutaminase. Antonyak, M.A., Boehm, J.E., Cerione, R.A. J. Biol. Chem. (2002) [Pubmed]
  11. Interaction of Chlamydia trachomatis serovar L2 with the host autophagic pathway. Al-Younes, H.M., Brinkmann, V., Meyer, T.F. Infect. Immun. (2004) [Pubmed]
  12. G protein-coupled receptors mediate two functionally distinct pathways of tyrosine phosphorylation in rat 1a fibroblasts. Shc phosphorylation and receptor endocytosis correlate with activation of Erk kinases. Luttrell, L.M., Daaka, Y., Della Rocca, G.J., Lefkowitz, R.J. J. Biol. Chem. (1997) [Pubmed]
  13. Development of selective inhibitors of transglutaminase. Phenylthiourea derivatives. Lee, K.N., Fesus, L., Yancey, S.T., Girard, J.E., Chung, S.I. J. Biol. Chem. (1985) [Pubmed]
  14. Characterization of 101-kDa transglutaminase from Physarum polycephalum and identification of LAV1-2 as substrate. Mottahedeh, J., Marsh, R. J. Biol. Chem. (1998) [Pubmed]
  15. Hepatocyte growth factor induces transglutaminase activity that negatively regulates the growth signal in primary cultured hepatocytes. Katoh, S., Nakagawa, N., Yano, Y., Satoh, K., Kohno, H., Ohkubo, Y., Suzuki, T., Kitani, K. Exp. Cell Res. (1996) [Pubmed]
  16. Induction of multiple programmed cell death pathways by IFN-beta in human non-small-cell lung cancer cell lines. Zhang, H., Koty, P.P., Mayotte, J., Levitt, M.L. Exp. Cell Res. (1999) [Pubmed]
  17. Transglutaminase-catalyzed matrix cross-linking in differentiating cartilage: identification of osteonectin as a major glutaminyl substrate. Aeschlimann, D., Kaupp, O., Paulsson, M. J. Cell Biol. (1995) [Pubmed]
  18. Core histones are glutaminyl substrates for tissue transglutaminase. Ballestar, E., Abad, C., Franco, L. J. Biol. Chem. (1996) [Pubmed]
  19. Cross-linking of laminin-nidogen complexes by tissue transglutaminase. A novel mechanism for basement membrane stabilization. Aeschlimann, D., Paulsson, M. J. Biol. Chem. (1991) [Pubmed]
  20. Rab7 is required for the normal progression of the autophagic pathway in mammalian cells. Gutierrez, M.G., Munafó, D.B., Berón, W., Colombo, M.I. J. Cell. Sci. (2004) [Pubmed]
  21. Rab22a affects the morphology and function of the endocytic pathway. Mesa, R., Salomón, C., Roggero, M., Stahl, P.D., Mayorga, L.S. J. Cell. Sci. (2001) [Pubmed]
  22. Inhibition of receptor internalization by monodansylcadaverine selectively blocks p55 tumor necrosis factor receptor death domain signaling. Schütze, S., Machleidt, T., Adam, D., Schwandner, R., Wiegmann, K., Kruse, M.L., Heinrich, M., Wickel, M., Krönke, M. J. Biol. Chem. (1999) [Pubmed]
  23. Transforming growth factor (TGF)-beta 1 internalization: modulation by ligand interaction with TGF-beta receptors types I and II and a mechanism that is distinct from clathrin-mediated endocytosis. Zwaagstra, J.C., El-Alfy, M., O'Connor-McCourt, M.D. J. Biol. Chem. (2001) [Pubmed]
  24. Degradation of Oxidized Proteins by Autophagy during Oxidative Stress in Arabidopsis. Xiong, Y., Contento, A.L., Nguyen, P.Q., Bassham, D.C. Plant Physiol. (2007) [Pubmed]
  25. Brugia malayi and Acanthocheilonema viteae: antifilarial activity of transglutaminase inhibitors in vitro. Rao, U.R., Mehta, K., Subrahmanyam, D., Vickery, A.C. Antimicrob. Agents Chemother. (1991) [Pubmed]
  26. Selective modification by transglutaminase of a glutamine side chain in the hinge region of the histidine-388----glutamine mutant of yeast phosphoglycerate kinase. Coussons, P.J., Kelly, S.M., Price, N.C., Johnson, C.M., Smith, B., Sawyer, L. Biochem. J. (1991) [Pubmed]
  27. AtATG18a is required for the formation of autophagosomes during nutrient stress and senescence in Arabidopsis thaliana. Xiong, Y., Contento, A.L., Bassham, D.C. Plant J. (2005) [Pubmed]
  28. Role of transglutaminase 1 in stabilisation of intercellular junctions of the vascular endothelium. Baumgartner, W., Golenhofen, N., Weth, A., Hiiragi, T., Saint, R., Griffin, M., Drenckhahn, D. Histochem. Cell Biol. (2004) [Pubmed]
  29. Evidence that the two amino termini of plasma fibronectin are in close proximity: a fluorescence energy transfer study. Wolff, C., Lai, C.S. Biochemistry (1988) [Pubmed]
  30. Transglutaminase differentially regulates growth signalling in rat perivenous and periportal hepatocytes. Maruko, A., Ohtake, Y., Konno, K., Abe, S., Ohkubo, Y. Cell Prolif. (2006) [Pubmed]
  31. Lipoprotein (a) is a substrate for factor XIIIa and tissue transglutaminase. Borth, W., Chang, V., Bishop, P., Harpel, P.C. J. Biol. Chem. (1991) [Pubmed]
  32. Site-specific modification of interleukin-2 by the combined use of genetic engineering techniques and transglutaminase. Sato, H., Ikeda, M., Suzuki, K., Hirayama, K. Biochemistry (1996) [Pubmed]
  33. Selective labelling of melittin with a fluorescent dansylcadaverine probe using guinea-pig liver transglutaminase. Pérez-Payá, E., Thiaudière, E., Abad, C., Dufourcq, J. FEBS Lett. (1991) [Pubmed]
  34. Rapid determination by high-performance liquid chromatography of free fatty acids released from rat platelets after derivatization with monodansylcadaverine. Lee, Y.M., Nakamura, H., Nakajima, T. J. Chromatogr. (1990) [Pubmed]
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