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Gene Review

CA8  -  carbonic anhydrase VIII

Homo sapiens

Synonyms: CA-VIII, CALS, CAMRQ3, CARP, Carbonic anhydrase VIII, ...
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Disease relevance of CA8


High impact information on CA8


Chemical compound and disease context of CA8

  • Arpp, a protein containing an ankyrin repeat domain, PEST sequence, and proline-rich region, is a novel ankyrin-repeated protein highly homologous to Carp, which is proposed to be the putative genetic marker for cardiac hypertrophy [7].

Biological context of CA8


Anatomical context of CA8

  • A recently reported mRNA, encoding 'carbonic anhydrase-related polypeptide' (CARP) from the Purkinje cells of mouse cerebellum, was shown to have a 30-40% deduced amino acid sequence identity with the carbonic anhydrases (CA) of mammals [9].
  • On the other hand, in adult cardiac muscle, interestingly, Arpp was expressed in ventricles mostly, whereas Carp was expressed throughout the atrium and ventricle [7].
  • Since ATP is the major organic phosphate in the erythrocytes of many fish, the binding of ATP to a representative fish hemoglobin (Carp I) was investigated [11].
  • Furthermore, although Carp was identified in fetal heart at 11 developmental weeks, Arpp was very low or undetectable in these fetal hearts [7].
  • Less than 5% of epithelial cells in normal colonic mucosae (n = 73) were CA-RP VIII-positive and these were localized to the deep part of the cryptal epithelium [12].

Associations of CA8 with chemical compounds


Other interactions of CA8


Analytical, diagnostic and therapeutic context of CA8


  1. Overexpression of carbonic anhydrase-related protein XI promotes proliferation and invasion of gastrointestinal stromal tumors. Morimoto, K., Nishimori, I., Takeuchi, T., Kohsaki, T., Okamoto, N., Taguchi, T., Yunoki, S., Watanabe, R., Ohtsuki, Y., Onishi, S. Virchows Arch. (2005) [Pubmed]
  2. Expression of carbonic anhydrase-related protein CA-RP VIII in non-small cell lung cancer. Akisawa, Y., Nishimori, I., Taniuchi, K., Okamoto, N., Takeuchi, T., Sonobe, H., Ohtsuki, Y., Onishi, S. Virchows Arch. (2003) [Pubmed]
  3. Two point mutations convert a catalytically inactive carbonic anhydrase-related protein (CARP) to an active enzyme. Sjöblom, B., Elleby, B., Wallgren, K., Jonsson, B.H., Lindskog, S. FEBS Lett. (1996) [Pubmed]
  4. Relation between Carp (multiple-sclerosis associated) agent and multiple sclerosis. Adams, D.H. Lancet (1976) [Pubmed]
  5. Colonic inhibition of pancreatic and biliary secretion. Owyang, C., Green, L., Rader, D. Gastroenterology (1983) [Pubmed]
  6. Carbonic anhydrase-related protein VIII: autoantigen in paraneoplastic cerebellar degeneration. Bataller, L., Sabater, L., Saiz, A., Serra, C., Claramonte, B., Graus, F. Ann. Neurol. (2004) [Pubmed]
  7. Carp, a cardiac ankyrin-repeated protein, and its new homologue, Arpp, are differentially expressed in heart, skeletal muscle, and rhabdomyosarcomas. Ishiguro, N., Baba, T., Ishida, T., Takeuchi, K., Osaki, M., Araki, N., Okada, E., Takahashi, S., Saito, M., Watanabe, M., Nakada, C., Tsukamoto, Y., Sato, K., Ito, K., Fukayama, M., Mori, S., Ito, H., Moriyama, M. Am. J. Pathol. (2002) [Pubmed]
  8. Sequence and tissue expression of a novel human carbonic anhydrase-related protein, CARP-2, mapping to chromosome 19q13.3. Bellingham, J., Gregory-Evans, K., Gregory-Evans, C.Y. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  9. The deduced amino acid sequence of human carbonic anhydrase-related protein (CARP) is 98% identical to the mouse homologue. Skaggs, L.A., Bergenhem, N.C., Venta, P.J., Tashian, R.E. Gene (1993) [Pubmed]
  10. Expression of the acatalytic carbonic anhydrase VIII gene, Car8, during mouse embryonic development. Lakkis, M.M., Bergenhem, N.C., O'Shea, K.S., Tashian, R.E. Histochem. J. (1997) [Pubmed]
  11. The effects of temperature and pH on the binding of ATP to carp (Cyprinus carpio) deoxyhemoglobin. Greaney, G.S., Hobish, M.K., Powers, D.A. J. Biol. Chem. (1980) [Pubmed]
  12. Overexpression of carbonic anhydrase-related protein VIII in human colorectal cancer. Miyaji, E., Nishimori, I., Taniuchi, K., Takeuchi, T., Ohtsuki, Y., Onishi, S. J. Pathol. (2003) [Pubmed]
  13. Enhancement of catalytic efficiency by the combination of site-specific mutations in a carbonic anhydrase-related protein. Elleby, B., Sjöblom, B., Tu, C., Silverman, D.N., Lindskog, S. Eur. J. Biochem. (2000) [Pubmed]
  14. cDNA sequence of human carbonic anhydrase-related protein, CA-RP X: mRNA expressions of CA-RP X and XI in human brain. Okamoto, N., Fujikawa-Adachi, K., Nishimori, I., Taniuchi, K., Onishi, S. Biochim. Biophys. Acta (2001) [Pubmed]
  15. cDNA sequence, mRNA expression, and chromosomal localization of human carbonic anhydrase-related protein, CA-RP XI. Fujikawa-Adachi, K., Nishimori, I., Taguchi, T., Yuri, K., Onishi, S. Biochim. Biophys. Acta (1999) [Pubmed]
  16. Parvalbumin in skeletal muscles of teleost (Tinca tinca L. and Misgurnus fossilis L.). Histochemical and immunohistochemical study. Zawadowska, B., Supiková, I. Folia Histochem. Cytobiol. (1992) [Pubmed]
  17. Increase in cytochrome oxidase capacity of BAT and other tissues in cold-acclimated gerbils. Bourhim, M., Barre, H., Oufara, S., Minaire, Y., Chatonnet, J., Cohen-Adad, F., Rouanet, J.L. Am. J. Physiol. (1990) [Pubmed]
  18. Assignment of the gene for human carbonic anhydrase VIII(CA8) to chromosome 8q11-->q12. Bergenhem, N.C., Sait, S.S., Eddy, R.L., Shows, T.B., Tashian, R.E. Cytogenet. Cell Genet. (1995) [Pubmed]
  19. Arpp, a new homolog of carp, is preferentially expressed in type 1 skeletal muscle fibers and is markedly induced by denervation. Tsukamoto, Y., Senda, T., Nakano, T., Nakada, C., Hida, T., Ishiguro, N., Kondo, G., Baba, T., Sato, K., Osaki, M., Mori, S., Ito, H., Moriyama, M. Lab. Invest. (2002) [Pubmed]
  20. Identification of a novel human ankyrin-repeated protein homologous to CARP. Moriyama, M., Tsukamoto, Y., Fujiwara, M., Kondo, G., Nakada, C., Baba, T., Ishiguro, N., Miyazaki, A., Nakamura, K., Hori, N., Sato, K., Shomori, K., Takeuchi, K., Satoh, H., Mori, S., Ito, H. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  21. L-Histidine ammonia-lyase activity of axenically grown Hartmannella culbertsoni. Singh, U.S., Raizada, M.K., Mohan Rao, V.K. Zentralblatt für Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Erste Abteilung Originale. Reihe A: Medizinische Mikrobiologie und Parasitologie. (1978) [Pubmed]
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