Disease relevance of TNIP3

• LIND (Listeria INDuced) was induced by Listeria infection, and is predicted to code for an M(r) 39,000 nuclear or cytoplasmic protein containing three coiled-coil domains [1].
• Comparison of Nissen total and Lind partial transabdominal fundoplication in the treatment of gastro-oesophageal reflux [2].
• In a previous report (K. Lind, Lancet ii:1158-1159, 1982), prominent serological cross-reactions were demonstrated between this mycoplasma and M. pneumoniae [3].
• A hydrogen peroxide toxoid of Ptx has been shown to be efficacious in preventing pertussis infections in a mass vaccination trial and is presently licensed in the United States and Europe (B. Trollfors, J. Taranger, T. Lagergard, L. Lind, V. Sundh, G. Zackrisson, C. U. Lowe, W. Blackwelder, and J. B. Robbins, N. Engl. J. Med. 333:1045-1050, 1995) [4].
• A total of 92 men and women with primary mild hypertension, aged 40-60 years, were selected and divided randomly into two groups, receiving either hydroalcoholic extract of C. curvisepala Lind. or placebo three times daily for more than 4 months [5].

High impact information on TNIP3

• Treatment of human monocytic cells with LPS strongly induced ABIN-3 mRNA and protein expression, suggesting a role for ABIN-3 in the LPS/TLR4 pathway [6].
• Three sets of mixed tetradecamer oligonucleotides were synthesized based on amino acid sequences in the 108-amino acid cell attachment domain (Pierschbacher, M. D., Ruoslahti, E., Sundelin, J., Lind, P., and Peterson, P. A. (1982) J. Biol. Chem. 257, 9593-9597) [7].
• When two or more muscle groups contract simultaneously at different relative tensions, the increments in heart rate and blood pressure are the same as when the muscle group at the higher relative tension contracts alone at that tension (Lind & McNicol, 1967) [8].
• 1. The cardiovascular responses to voluntary isometric contractions performed by human subjects are determined by the proportion of maximal tension achieved by the muscles contracting, and not by the mass of the contracting muscles, nor by the absolute tension achieved (Lind & McNicol, 1967; confirmed here) [8].
• A standard Gibbs energy of formation of 16.6 kcal mol(-)(1) has been reported for peroxynitrite [Merényi, G., and Lind, J. (1998) Chem. Res. Toxicol. 11, 243-246] [9].

Biological context of TNIP3

• Epidemiology in food safety evaluation - past and present (James Lind, George Baker) [10].
• Antimicrobial, wound healing and antioxidant activity of Plagiochasma appendiculatum Lehm. et Lind [11].

Anatomical context of TNIP3

• Two novel genes FIND and LIND differentially expressed in deactivated and Listeria-infected human macrophages [1].
• In a previously reported phase I trial (Lind et al., J Clin Oncol 1996; 14: 800-5), carboplatin dose intensity was increased by the use of G-CSF to support the bone marrow and using pharmacokinetically-guided carboplatin dosing [12].
• The most common of these are central nervous system (CNS) complications (Lind, 1979) including meningitis, encephalitis, cranial nerve palsies, ascending paralysis (Guillain-Barre-like), transverse myelitis, cerebellar ataxia, polyradiculitis and acute psychosis [13].

Associations of TNIP3 with chemical compounds

• Recent thermodynamic calculations of Merenyi and Lind [(1997) Chem. Res. Toxicol. 10, 1216-1220] suggest that O=NOOH can undergo homolysis to form the hydroxyl radical and nitrogen dioxide [14].
• The aim of the present study was to investigate the potential antihypertensive effects of extracts of the flavonoid-rich Iranian flower, Crataegus curvisepala Lind., a member of the Rosaceae family [5].
• The luminol analogue phthalhydrazide, which was suggested by Merényi and Lind as a reliable OH. detector, can replace luminol only in phosphate buffer, and thus turns out to be very specific indeed for free OH. [15].

Analytical, diagnostic and therapeutic context of TNIP3

• Antihypertensive effect of Iranian Crataegus curvisepala Lind.: a randomized, double-blind study [5].
• Fifty five patients underwent a minimal invasive approach: 49 Nissen (are the total fundoplication) and 3 Lind (are the partial fundoplication) operations through laparoscopy, 3 Belsey Mark IV through video assisted thoracic surgery (VATS) [16].
• Lind is revered as the first doctor to conduct systematic clinical trials of potential cures for scurvy-trials in which oranges and lemons came out as decisive winners [17].
• This study is a retrospective study of patients submitted to surgery using the Lind procedure for gastroesophageal reflux disease (GERD) [18].
• Esophageal manometry and 24-hour pH monitoring to evaluate laparoscopic Lind fundoplication in gastroesophageal reflux disease [18].

References