The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

SRCIN1  -  SRC kinase signaling inhibitor 1

Homo sapiens

Synonyms: KIAA1684, P140, SNAP-25-interacting protein, SNIP, p130Cas-associated protein, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of SNIP

  • Analysis of another event-related potential, P140 (a measure of the sensory processes), showed no change in response to hypoglycemia [1].
  • The fractionation behavior of NCP98 is, however, similar to that of the P140 encoded by a temperature-sensitive strain of Fujinami sarcoma virus in infected cells grown at the nonpermissive temperature [2].
  • In this study, for the first time in the context of infectious HIV-1 particles, we analyzed the contribution of amino acid residues (S134, I135, N136, N137, T139 and P140) in the beta7-beta8 loop for RT heterodimerization, enzymatic activity, and virus infectivity [3].
  • Stability of cytadherence-related proteins P140/P110 in Mycoplasma genitalium requires MG218 and unidentified factors [4].

High impact information on SNIP

  • Its tyrosine phosphorylation by integrin-mediated adhesion and EGF stimulation and its involvement in cell spreading on matrix proteins suggest that p140Cap plays a role in controlling actin cytoskeleton organization in response to adhesive and growth factor signaling [5].
  • In addition p140Cap codistributes with cortical actin and actin stress fibers but not with focal adhesions [5].
  • By immunofluorescence analysis, we demonstrated that in ECV304 cells plated on fibronectin, the endogenous p140Cap colocalizes with p130Cas in the perinuclear region as well as in lamellipodia [5].
  • P140, an event-related potential reflecting sensory processes, was not altered [6].
  • We compared the intracellular location of the product of the c-fps proto-oncogene, NCP98, with that of its viral homolog P140, the transforming protein of Fujinami sarcoma virus [2].

Biological context of SNIP

  • Loss of either P140 or P110 yields a hemadsorption-negative phenotype and correlates with decreased or increased levels of cytoskeleton-related proteins MG386 and DnaK, respectively [7].
  • We have deleted by homologous recombination the mg191 and mg192 genes from the MgPa operon encoding the P140 and P110 cytadhesins [7].
  • Amino acids N137 and P140 in the p51 subunit of HIV-1 reverse transcriptase (RT) are part of the beta7-beta8-loop that contributes to the formation of the base of the non-nucleoside RT inhibitor (NNRTI)-binding pocket and makes up a substantial part of the dimerization interface [8].
  • Preincubation of platelets with the tyrosine phosphatase inhibitor orthovanadate prevented the tyrosine dephosphorylation of P38 and P140, and reduced platelet aggregation induced by thrombin receptor activation [9].

Anatomical context of SNIP

  • SIP30 is expressed abundantly in brain and slightly in testis and kidney [10].
  • This fractionation behavior differs from that of P140, which is found predominantly in the particulate fraction, both in Fujinami sarcoma virus-infected chicken embryo fibroblasts and in Fujinami sarcoma virus-infected myeloblasts [2].
  • Scanning electron microscopy analysis reveals the absolute requirement of P140 and P110 for the proper development of the attachment organelle [7].
  • Using crossed immunoelectrophoresis with an antiserum raised against immature rat cerebellar plasma membrane preparations (anti-BPM serum) that primarily recognizes one neuronal surface antigen (D2)33, it was established that the P140 comprises the D2 protein [11].
  • RESULTS: The endothelial cell count showed significant (P < .001) reduction by approximately 10% after the "Reversed Tip and Snip" technique and by approximately 15% (P < .001) after the "Divide and Conquer" technique [12].

Associations of SNIP with chemical compounds

  • Activation of human platelets by thrombin or a thrombin receptor-activating peptide (TRAP) resulted in a decrease in tyrosine phosphorylation of two proteins, P38 and P140 [9].
  • When platelets were stimulated under conditions that precluded the activation of glycoprotein IIb/IIIa (dissociation of the complex by EGTA at 37 degrees C) or the binding of fibrinogen (preincubation of platelets with RGDS), tyrosine dephosphorylation of P38 and P140 was not observed [9].
  • Laboratory tests also proved that moistening the fly prolonged the efficacy period of the three tested products from 3 to 6 weeks in case of Alfacron SB, from 4 to 7 weeks for Snip IRB and from 7 to 9 weeks in case of Alfacron 10 WP [13].

Analytical, diagnostic and therapeutic context of SNIP


  1. Hypoglycemic thresholds for cognitive dysfunction in humans. Blackman, J.D., Towle, V.L., Lewis, G.F., Spire, J.P., Polonsky, K.S. Diabetes (1990) [Pubmed]
  2. Cellular localization of c-fps gene product NCP98. Young, J.C., Martin, G.S. J. Virol. (1984) [Pubmed]
  3. Analysis of Amino Acids in the beta7-beta8 Loop of Human Immunodeficiency Virus Type 1 Reverse Transcriptase for their Role in Virus Replication. Mulky, A., Vu, B.C., Conway, J.A., Hughes, S.H., Kappes, J.C. J. Mol. Biol. (2007) [Pubmed]
  4. Stability of cytadherence-related proteins P140/P110 in Mycoplasma genitalium requires MG218 and unidentified factors. Dhandayuthapani, S., Rasmussen, W.G., Baseman, J.B. Arch. Med. Res. (2002) [Pubmed]
  5. P130Cas-associated protein (p140Cap) as a new tyrosine-phosphorylated protein involved in cell spreading. Di Stefano, P., Cabodi, S., Boeri Erba, E., Margaria, V., Bergatto, E., Giuffrida, M.G., Silengo, L., Tarone, G., Turco, E., Defilippi, P. Mol. Biol. Cell (2004) [Pubmed]
  6. Hypoglycemic thresholds for cognitive dysfunction in IDDM. Blackman, J.D., Towle, V.L., Sturis, J., Lewis, G.F., Spire, J.P., Polonsky, K.S. Diabetes (1992) [Pubmed]
  7. Mycoplasma genitalium P140 and P110 Cytadhesins Are Reciprocally Stabilized and Required for Cell Adhesion and Terminal-Organelle Development. Burgos, R., Pich, O.Q., Ferrer-Navarro, M., Baseman, J.B., Querol, E., Pi??ol, J. J. Bacteriol. (2006) [Pubmed]
  8. The N137 and P140 amino acids in the p51 and the P95 amino acid in the p66 subunit of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase are instrumental to maintain catalytic activity and to design new classes of anti-HIV-1 drugs. Auwerx, J., Van Nieuwenhove, J., Rodríguez-Barrios, F., de Castro, S., Velázquez, S., Ceccherini-Silberstein, F., De Clercq, E., Camarasa, M.J., Perno, C.F., Gago, F., Balzarini, J. FEBS Lett. (2005) [Pubmed]
  9. Integrin-dependent protein dephosphorylation on tyrosine induced by activation of the thrombin receptor in human platelets. Luber, K., Siess, W. Cell. Signal. (1994) [Pubmed]
  10. Identification of a novel SNAP25 interacting protein (SIP30). Lee, H.K., Safieddine, S., Petralia, R.S., Wenthold, R.J. J. Neurochem. (2002) [Pubmed]
  11. Development of cerebellar cells in neuron-enriched cultures: cell surface proteins. Annunziata, P., Regan, C., Balázs, R. Brain Res. (1983) [Pubmed]
  12. Endothelial cell loss secondary to two different phacoemulsification techniques. Kohlhaas, M., Klemm, M., Kammann, J., Richard, G. Ophthalmic surgery and lasers. (1998) [Pubmed]
  13. Evaluation of insecticidal efficiency of certain new selective formulations against Musca domestica (L). Hafez, J.A. Journal of the Egyptian Society of Parasitology. (1992) [Pubmed]
WikiGenes - Universities