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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Ethics Committees, Research

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Disease relevance of Ethics Committees, Research

  • A nuclear magnetic resonance surface coil placed under the right hemidiaphragm measured P(i) and PCr during four conditions: control, inspiratory resistive breathing (IRB), IRB with hypoxia, and recovery (IRB without hypoxia) [1].
  • On the other hand, the effect of IRB on the HR suggested that angiotensin II modulates this parameter in ACo animals at an early stage of hypertension [2].
  • METHODS: With IRB approval, human proximal esophageal pouch and distal fistula samples were removed at the time of standard repair of EA/TEF in accordance with what the surgeons deemed appropriate in preparation for anastomosis [3].
  • METHODS: After IRB approved informed consent, 170 white women and 30 African American women with known breast cancer diagnosed at a young age (45 years or less) underwent complete sequencing of the BRCA1 and BRCA2 genes [4].

High impact information on Ethics Committees, Research

  • SETTING.--Studies approved in 1980 or prior to 1980 by the two institutional review boards that serve The Johns Hopkins Health Institutions--one that serves the School of Medicine and Hospital and the other that serves the School of Hygiene and Public Health. POPULATION.--A total of 737 studies were followed up [5].
  • Ironically, this apparent federal crackdown began at the same time that two federal review panels called for major changes in the regulations governing local IRBs [6].
  • Activation of protein kinase C by phorbol esters did induce c-fos, c-myc, and JE in IRB cells, indicating that signalling pathways distal to this enzyme remained intact [7].
  • We have previously shown that IFN-inducible enzyme activities, including double-stranded RNA-dependent eIF2 kinase and 2',5'-oligoadenylate synthetase, are normal in IRB cells [7].
  • Sequential pre- and post-EIA seroconversion sera from 35 HIV-infected homosexual men were tested by the IRB assay using IgM- and IgG-specific fluorescent probes [8].

Biological context of Ethics Committees, Research


Anatomical context of Ethics Committees, Research


Associations of Ethics Committees, Research with chemical compounds


Gene context of Ethics Committees, Research

  • Treatment with IRB could markedly inhibit the renal expression of CTGF [19].
  • Sequence analysis revealed that murine Mcl1/EAT (mMcl1/EAT) has three Bcl-2 homology domains, two PEST sequences, and immediate response boxes (IRB) [20].
  • These included 58 of 99 (59%) institutional protocols approved by The Johns Hopkins Oncology Center's Clinical Research Committee and the Institutional Review Board (IRB) over a 2-year period, and 30 active Eastern Cooperative Oncology Group (ECOG), Radiation Therapy Oncology Group (RTOG), and Pediatric Oncology Group (POG) trials [21].
  • In addition, we treated wild-type rats with IRB and/or the B1R antagonist, B9958, and determined the left ventricular (LV) function [9].
  • Approval for use of autopsy lungs was given by the head of the pathology institute of the university, in accordance with the requirements of the State Ministry of Science and Arts and without the need for institutional review board approval [22].

Analytical, diagnostic and therapeutic context of Ethics Committees, Research


  1. Effects of loaded breathing and hypoxia on diaphragm metabolism as measured by (31)P-NMR spectroscopy. Radell, P.J., Eleff, S.M., Nichols, D.G. J. Appl. Physiol. (2000) [Pubmed]
  2. Pharmacokinetics and the cardiovascular effects of irbesartan in aortic coarctated rats. Höcht, C., Opezzo, J.A., Taira, C.A. Pharmacology (2004) [Pubmed]
  3. A role for sonic hedgehog signaling in the pathogenesis of human tracheoesophageal fistula. Spilde, T., Bhatia, A., Ostlie, D., Marosky, J., Holcomb, G., Snyder, C., Gittes, G. J. Pediatr. Surg. (2003) [Pubmed]
  4. Racial differences in the incidence of BRCA1 and BRCA2 mutations in a cohort of early onset breast cancer patients: African American compared to white women. Haffty, B.G., Silber, A., Matloff, E., Chung, J., Lannin, D. J. Med. Genet. (2006) [Pubmed]
  5. Factors influencing publication of research results. Follow-up of applications submitted to two institutional review boards. Dickersin, K., Min, Y.I., Meinert, C.L. JAMA (1992) [Pubmed]
  6. Breaking the camel's back: multicenter clinical trials and local institutional review boards. Burman, W.J., Reves, R.R., Cohn, D.L., Schooley, R.T. Ann. Intern. Med. (2001) [Pubmed]
  7. BALB/c-3T3 fibroblasts resistant to growth inhibition by beta interferon exhibit aberrant platelet-derived growth factor, epidermal growth factor, and fibroblast growth factor signal transduction. Mundschau, L.J., Faller, D.V. Mol. Cell. Biol. (1991) [Pubmed]
  8. Early detection of antibodies against rDNA-produced HIV proteins with a flow cytometric assay. Scillian, J.J., McHugh, T.M., Busch, M.P., Tam, M., Fulwyler, M.J., Chien, D.Y., Vyas, G.N. Blood (1989) [Pubmed]
  9. The bradykinin B1 receptor contributes to the cardioprotective effects of AT1 blockade after experimental myocardial infarction. Tschöpe, C., Spillmann, F., Altmann, C., Koch, M., Westermann, D., Dhayat, N., Dhayat, S., Bascands, J.L., Gera, L., Hoffmann, S., Schultheiss, H.P., Walther, T. Cardiovasc. Res. (2004) [Pubmed]
  10. The pharmacokinetics of epidural lidocaine and bupivacaine during cesarean section. Downing, J.W., Johnson, H.V., Gonzalez, H.F., Arney, T.L., Herman, N.L., Johnson, R.F. Anesth. Analg. (1997) [Pubmed]
  11. Differential expression of the partially duplicated chloroplast S10 ribosomal protein operon. Tonkyn, J.C., Gruissem, W. Mol. Gen. Genet. (1993) [Pubmed]
  12. Catheter-directed thrombolysis in deep venous thrombosis with use of reteplase: immediate results and complications from a pilot study. Castaneda, F., Li, R., Young, K., Swischuk, J.L., Smouse, B., Brady, T. Journal of vascular and interventional radiology : JVIR. (2002) [Pubmed]
  13. Surgical treatment for congestive heart failure with autologous adult stem cell transplantation: a prospective randomized study. Patel, A.N., Geffner, L., Vina, R.F., Saslavsky, J., Urschel, H.C., Kormos, R., Benetti, F. J. Thorac. Cardiovasc. Surg. (2005) [Pubmed]
  14. Brain mapping of deception and truth telling about an ecologically valid situation: functional MR imaging and polygraph investigation--initial experience. Mohamed, F.B., Faro, S.H., Gordon, N.J., Platek, S.M., Ahmad, H., Williams, J.M. Radiology. (2006) [Pubmed]
  15. Desflurane enhances reactivity during the use of the laryngeal mask airway. Arain, S.R., Shankar, H., Ebert, T.J. Anesthesiology (2005) [Pubmed]
  16. Levobupivacaine 0.125% and lidocaine 0.5% for intravenous regional anesthesia in volunteers. Atanassoff, P.G., Aouad, R., Hartmannsgruber, M.W., Halaszynski, T. Anesthesiology (2002) [Pubmed]
  17. A multi-center study of intrathecal neostigmine for analgesia following vaginal hysterectomy. Lauretti, G.R., Hood, D.D., Eisenach, J.C., Pfeifer, B.L. Anesthesiology (1998) [Pubmed]
  18. Propofol dosing regimens for ICU sedation based upon an integrated pharmacokinetic-pharmacodynamic model. Barr, J., Egan, T.D., Sandoval, N.F., Zomorodi, K., Cohane, C., Gambus, P.L., Shafer, S.L. Anesthesiology (2001) [Pubmed]
  19. Connective tissue growth factor-mediated angiotensin II-induced hypertrophy of proximal tubular cells. Liu, B.C., Chen, L., Sun, J., Huang, H.Q., Ma, K.L., Liu, H., Liu, D.G., Zhang, X.L. Nephron Exp. Nephrol. (2006) [Pubmed]
  20. Up-regulated expression of murine Mcl1/EAT, a bcl-2 related gene, in the early stage of differentiation of murine embryonal carcinoma cells and embryonic stem cells. Okita, H., Umezawa, A., Suzuki, A., Hata, J. Biochim. Biophys. Acta (1998) [Pubmed]
  21. Are informed consent forms that describe clinical oncology research protocols readable by most patients and their families? Grossman, S.A., Piantadosi, S., Covahey, C. J. Clin. Oncol. (1994) [Pubmed]
  22. Micro-CT of the human lung: imaging of alveoli and virtual endoscopy of an alveolar duct in a normal lung and in a lung with centrilobular emphysema--initial observations. Watz, H., Breithecker, A., Rau, W.S., Kriete, A. Radiology. (2005) [Pubmed]
  23. Ambulatory surgery patients may be discharged before voiding after short-acting spinal and epidural anesthesia. Mulroy, M.F., Salinas, F.V., Larkin, K.L., Polissar, N.L. Anesthesiology (2002) [Pubmed]
  24. Fast track anesthesia for liver transplantation reduces postoperative ventilation time but not intensive care unit stay. Findlay, J.Y., Jankowski, C.J., Vasdev, G.M., Chantigian, R.C., Gali, B., Kamath, G.S., Keegan, M.T., Hall, B.A., Jones, K.A., Burkle, C.M., Plevak, D.J. Liver Transpl. (2002) [Pubmed]
  25. Thiopental and desflurane treatment for brain protection. Hoffman, W.E., Charbel, F.T., Edelman, G., Ausman, J.I. Neurosurgery (1998) [Pubmed]
  26. A two-center comparison of the cardiovascular effects of cisatracurium (Nimbex) and vecuronium in patients with coronary artery disease. Konstadt, S.N., Reich, D.L., Stanley, T.E., DePerio, M., Chuey, C., Schwartzbach, C., Abou-Donia, M. Anesth. Analg. (1995) [Pubmed]
  27. Femtosecond laser versus mechanical keratome flaps in wavefront-guided laser in situ keratomileusis: prospective contralateral eye study. Durrie, D.S., Kezirian, G.M. Journal of cataract and refractive surgery. (2005) [Pubmed]
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