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Dnajb1  -  DnaJ (Hsp40) homolog, subfamily B, member 1

Mus musculus

Synonyms: 0610007I11Rik, DnaJ homolog subfamily B member 1, HSP40, HSPF1, Heat shock 40 kDa protein 1, ...
 
 
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Disease relevance of Dnajb1

  • Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity [1].
  • In contrast, the location of helix 1 differs from the substrate binding regions of two other Hsp40 proteins, Escherichia coli Hsc20 and viral large T antigen [2].
  • HSP40 protein expression was also enhanced in the pyramidal and dentate granular neurons from 2 to 4 days after ischemia [3].
  • Synergistic induction of HSP40 and HSC70 in the mouse hippocampal neurons after cerebral ischemia and ischemic tolerance in gerbil hippocampus [3].
  • Immunogenicity and protective efficacy of DnaJ (hsp40) of Streptococcus pneumoniae against lethal infection in mice [4].
 

High impact information on Dnajb1

  • 17-AAG also mildly induced Hsp70 and Hsp40 [5].
  • Cysteine string protein alpha (CSPalpha)--an abundant synaptic vesicle protein that contains a DNA-J domain characteristic of Hsp40 chaperones--is thought to regulate Ca2+ channels and/or synaptic vesicle exocytosis [6].
  • Here we demonstrate that newly synthesized polyglutamine-expanded truncated huntingtin interacts with members of Hsp40 and Hsp70 families of chaperones in a polyglutamine length-dependent manner [1].
  • The N-terminal 70 residues of TAg have significant homology to the J domain of Hsp40/DnaJ and cooperate with the LXCXE motif to inactivate the pRB family [7].
  • Addition of Hop or Ydj1 had no affect on the rate or magnitude of the activation of the stripped receptors, and quantitative Western blots confirmed that neither Hop or Hsp40 were present in our protein preparations or in the stripped receptors [8].
 

Biological context of Dnajb1

  • Using Iba1 as a bait, we performed yeast Two-hybrid screening and isolated a heat-shock protein Hsp40, DjB1, from cDNA library of mouse testis [9].
  • Although the temperature shift from 33 degrees C (permissive temperature) to 39 degrees C (nonpermissive temperature) induced increases in the endogenous chaperones including Hsp70 and Hsp40, degradation of the T antigen, activation of the p53-p21(waf1) pathway, and an arrest of cell growth were observed in the mock cells [10].
  • Tumor response correlated with an increase in the appearance of prelamin A, but no changes in the prenylation of lamin B, heat shock protein 40, or N-Ras were detectable [11].
  • Based on the current observation that both HSP40 and HSC70 proteins were synergistically expressed in the ischemia-resistant and tolerance-acquired neurons, cochaperone HSP40 may play a significant role against postischemic neuronal response and lead to cell survival through interaction with simultaneously induced HSC70 [3].
  • The gene expression profile analysis of cisplatin-treated cells identified a number of genes with robust up regulation of mRNA expression including genes associated with DNA damage (i.e. members of GADD45 family), early response (i.e. cFOS), and heat shock protein (i.e. HSP40 homologue) [12].
 

Anatomical context of Dnajb1

  • Dnajb1 mRNA was exclusively expressed in spermatocytes and round spermatids in mouse testis, and Dnajb1 protein DjB1 was predominantly expressed in the cytoplasm of spermatocytes, round spermatids, and elongating spermatids [9].
  • The murine Hsp40 gene was expressed at a high level in testis and was induced by heat shock [13].
  • Auxilin is an Hsp40 family protein that catalytically supports the uncoating of clathrin-coated vesicles through recruitment of Hsc70 in an ATP hydrolysis-driven process [2].
  • Identification of a heat-shock protein Hsp40, DjB1, as an acrosome- and a tail-associated component in rodent spermatozoa [9].
  • In the gerbil transient forebrain ischemia model, both HSP40 and HSC70 proteins were expressed strongly in ischemia-resistant CA3 neurons and dentate granule cells 1 day after 5 min ischemia, but were not expressed in vulnerable CA1 neurons [3].
 

Other interactions of Dnajb1

  • We also show that Hsp40 is not essential for GR folding by the five-protein system but enhances a process that occurs less effectively when it is not present [14].
  • HSP40 has a critical regulatory function in the HSC70 ATPase activity [3].
  • Msj-1, a DNAJ/HSP40 protein located around the spermatozoa acrosome, was recently found to be down-regulated in the testis of wobbler mutant mice [15].
  • Caspase-3 activation, heat shock protein (HSP) 70, and HSP40 were assessed by western blotting [16].
  • However, the presence of a synthetic RNA containing the sequence bound by these four proteins does increase the amount of co-precipitated protein, in particular the amount of HSP60 which is brought down with antibodies directed against HSP40 and mtHSP70 [17].
 

Analytical, diagnostic and therapeutic context of Dnajb1

References

  1. Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity. Jana, N.R., Tanaka, M., Wang, G., Nukina, N. Hum. Mol. Genet. (2000) [Pubmed]
  2. Structure of the functional fragment of auxilin required for catalytic uncoating of clathrin-coated vesicles. Gruschus, J.M., Han, C.J., Greener, T., Ferretti, J.A., Greene, L.E., Eisenberg, E. Biochemistry (2004) [Pubmed]
  3. Synergistic induction of HSP40 and HSC70 in the mouse hippocampal neurons after cerebral ischemia and ischemic tolerance in gerbil hippocampus. Tanaka, S., Kitagawa, K., Ohtsuki, T., Yagita, Y., Takasawa, K., Hori, M., Matsumoto, M. J. Neurosci. Res. (2002) [Pubmed]
  4. Immunogenicity and protective efficacy of DnaJ (hsp40) of Streptococcus pneumoniae against lethal infection in mice. Khan, M.N., Bansal, A., Shukla, D., Paliwal, P., Sarada, S.K., Mustoori, S.R., Banerjee, P.K. Vaccine (2006) [Pubmed]
  5. 17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration. Waza, M., Adachi, H., Katsuno, M., Minamiyama, M., Sang, C., Tanaka, F., Inukai, A., Doyu, M., Sobue, G. Nat. Med. (2005) [Pubmed]
  6. The synaptic vesicle protein CSP alpha prevents presynaptic degeneration. Fernández-Chacón, R., Wölfel, M., Nishimune, H., Tabares, L., Schmitz, F., Castellano-Muñoz, M., Rosenmund, C., Montesinos, M.L., Sanes, J.R., Schneggenburger, R., Südhof, T.C. Neuron (2004) [Pubmed]
  7. Loss of p19(ARF) eliminates the requirement for the pRB-binding motif in simian virus 40 large T antigen-mediated transformation. Chao, H.H., Buchmann, A.M., DeCaprio, J.A. Mol. Cell. Biol. (2000) [Pubmed]
  8. The molecular chaperones Hsp90 and Hsc70 are both necessary and sufficient to activate hormone binding by glucocorticoid receptor. Rajapandi, T., Greene, L.E., Eisenberg, E. J. Biol. Chem. (2000) [Pubmed]
  9. Identification of a heat-shock protein Hsp40, DjB1, as an acrosome- and a tail-associated component in rodent spermatozoa. Doiguchi, M., Kaneko, T., Urasoko, A., Nishitani, H., Iida, H. Mol. Reprod. Dev. (2007) [Pubmed]
  10. Overexpression of heat shock protein 70 restores the structural stability and functional defects of temperature-sensitive mutant of large T antigen at nonpermissive temperature. Tabuchi, Y., Kuribayashi, R., Takasaki, I., Doi, T., Sakai, H., Takeguchi, N., Kondo, T., Ohtsuka, K. Cell Stress Chaperones (2006) [Pubmed]
  11. Preclinical antitumor activity and pharmacodynamic studies with the farnesyl protein transferase inhibitor R115777 in human breast cancer. Kelland, L.R., Smith, V., Valenti, M., Patterson, L., Clarke, P.A., Detre, S., End, D., Howes, A.J., Dowsett, M., Workman, P., Johnston, S.R. Clin. Cancer Res. (2001) [Pubmed]
  12. Differentiation of DNA reactive and non-reactive genotoxic mechanisms using gene expression profile analysis. Dickinson, D.A., Warnes, G.R., Quievryn, G., Messer, J., Zhitkovich, A., Rubitski, E., Aubrecht, J. Mutat. Res. (2004) [Pubmed]
  13. Cloning and expression of murine sp40 gene: differences in initiation sites between heat-induced and constitutive transcripts. Hata, M., Ohtsuka, K. DNA Seq. (2000) [Pubmed]
  14. The Hsp organizer protein hop enhances the rate of but is not essential for glucocorticoid receptor folding by the multiprotein Hsp90-based chaperone system. Morishima, Y., Kanelakis, K.C., Silverstein, A.M., Dittmar, K.D., Estrada, L., Pratt, W.B. J. Biol. Chem. (2000) [Pubmed]
  15. Early defect in the expression of mouse sperm DNAJ 1, a member of the DNAJ/heat shock protein 40 chaperone protein family, in the spinal cord of the wobbler mouse, a murine model of motoneuronal degeneration. Boillée, S., Berruti, G., Meccariello, R., Grannec, G., Razan, F., Pierantoni, R., Fasano, S., Junier, M.P. Neuroscience (2002) [Pubmed]
  16. Hypertonic saline resuscitation reduces apoptosis and tissue damage of the small intestine in a mouse model of hemorrhagic shock. Murao, Y., Hata, M., Ohnishi, K., Okuchi, K., Nakajima, Y., Hiasa, Y., Junger, W.G., Hoyt, D.B., Ohnishi, T. Shock (2003) [Pubmed]
  17. Mitochondrial HSP70, HSP40, and HSP60 bind to the 3' untranslated region of the Murine hepatitis virus genome. Nanda, S.K., Johnson, R.F., Liu, Q., Leibowitz, J.L. Arch. Virol. (2004) [Pubmed]
 
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