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TESK1  -  testis-specific kinase 1

Homo sapiens

Synonyms: Dual specificity testis-specific protein kinase 1, Testicular protein kinase 1
 
 
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High impact information on TESK1

 

Biological context of TESK1

 

Anatomical context of TESK1

  • In HeLa cells, TESK1, together with 14-3-3beta, accumulated at the cell periphery when cells were plated on fibronectin, whereas they were diffusely distributed in the cytoplasm in the case of non-stimulated cells [4].
  • Identification and characterization of TESK2, a novel member of the LIMK/TESK family of protein kinases, predominantly expressed in testis [6].
  • Identification and characterization of a novel protein kinase, TESK1, specifically expressed in testicular germ cells [5].
  • The TESK1 mRNA in the testis was detectable only after the 18th day of postnatal development of mice and was mainly expressed in the round spermatids [5].
  • Expression of Spry4 in cultured cells suppressed integrin-mediated cell spreading, and TESK1 reversed the inhibitory effect of Spry4 on cell spreading [7].
 

Associations of TESK1 with chemical compounds

 

Enzymatic interactions of TESK1

 

Regulatory relationships of TESK1

  • Drosophila center divider gene is expressed in CNS midline cells and encodes a developmentally regulated protein kinase orthologous to human TESK1 [9].
 

Other interactions of TESK1

  • We previously showed that TESK1 interacts with Sprouty-4 (referred to as Spry4), an inhibitor of growth factor-induced Ras/MAP (mitogen-activated protein) kinase signalling, but the functional role of this interaction has remained unknown [7].
 

Analytical, diagnostic and therapeutic context of TESK1

References

  1. Actopaxin interacts with TESK1 to regulate cell spreading on fibronectin. LaLonde, D.P., Brown, M.C., Bouverat, B.P., Turner, C.E. J. Biol. Chem. (2005) [Pubmed]
  2. Cofilin phosphorylation and actin reorganization activities of testicular protein kinase 2 and its predominant expression in testicular Sertoli cells. Toshima, J., Toshima, J.Y., Takeuchi, K., Mori, R., Mizuno, K. J. Biol. Chem. (2001) [Pubmed]
  3. Cofilin phosphorylation by protein kinase testicular protein kinase 1 and its role in integrin-mediated actin reorganization and focal adhesion formation. Toshima, J., Toshima, J.Y., Amano, T., Yang, N., Narumiya, S., Mizuno, K. Mol. Biol. Cell (2001) [Pubmed]
  4. Binding of 14-3-3beta regulates the kinase activity and subcellular localization of testicular protein kinase 1. Toshima, J.Y., Toshima, J., Watanabe, T., Mizuno, K. J. Biol. Chem. (2001) [Pubmed]
  5. Identification and characterization of a novel protein kinase, TESK1, specifically expressed in testicular germ cells. Toshima, J., Ohashi, K., Okano, I., Nunoue, K., Kishioka, M., Kuma, K., Miyata, T., Hirai, M., Baba, T., Mizuno, K. J. Biol. Chem. (1995) [Pubmed]
  6. Identification and characterization of TESK2, a novel member of the LIMK/TESK family of protein kinases, predominantly expressed in testis. Røsok, O., Pedeutour, F., Ree, A.H., Aasheim, H.C. Genomics (1999) [Pubmed]
  7. Sprouty-4 negatively regulates cell spreading by inhibiting the kinase activity of testicular protein kinase. Tsumura, Y., Toshima, J., Leeksma, O.C., Ohashi, K., Mizuno, K. Biochem. J. (2005) [Pubmed]
  8. Dual specificity protein kinase activity of testis-specific protein kinase 1 and its regulation by autophosphorylation of serine-215 within the activation loop. Toshima, J., Tanaka, T., Mizuno, K. J. Biol. Chem. (1999) [Pubmed]
  9. Drosophila center divider gene is expressed in CNS midline cells and encodes a developmentally regulated protein kinase orthologous to human TESK1. Matthews, B.B., Crews, S.T. DNA Cell Biol. (1999) [Pubmed]
 
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