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Gene Review

CDS1  -  phosphatidate cytidylyltransferase

Saccharomyces cerevisiae S288c

Synonyms: CDG1, CDP-DAG synthase, CDP-DG synthase, CDP-diacylglycerol synthase, CDP-diglyceride pyrophosphorylase, ...
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Disease relevance of CDS1


High impact information on CDS1

  • We identified Chk2, the mammalian homolog of the Saccharomyces cerevisiae Rad53 and Schizosaccharomyces pombe Cds1 protein kinases required for the DNA damage and replication checkpoints [2].
  • Here, we show that after a replication perturbation, cells exhibit a mutator phenotype, which can be significantly affected by mutations in the checkpoint elements Cds1 and Rad17 or translesion synthesis polymerases DinB and Polzeta [3].
  • The mitotic checkpoint Rad genes and the Cds1 protein kinase are required for the DNA replication checkpoint during meiosis, with Cds1 playing a more prominent role than it does during mitosis [4].
  • Here, we show that the Cds1 kinase is required to slow S phase in the presence of DNA-damaging agents [5].
  • Cells lacking Cid1 were found to be viable but specifically sensitive to the combination of hydroxyurea and caffeine and to be S-M checkpoint defective in the absence of Cds1 [6].

Biological context of CDS1


Anatomical context of CDS1


Associations of CDS1 with chemical compounds


Other interactions of CDS1

  • PI synthase activity follows the decrease of the CDP-DAG synthase activity, but there is no parallel change in the level of PIS1 mRNA [12].
  • INO1 mRNA also increases but only after CDP-DAG synthase activity falls below the wild type level [12].
  • By functional complementation of the auxotrophic requirements for choline of a cdg1, cho2 double-mutant, by transformation with a genomic DNA library in a high copy number plasmid, two different types of complementing DNA inserts were identified [16].
  • The results reveal an important mechanistic difference to the homologous Schizosaccharomyces pombe FHA domain that is required for Mrc1-dependent activation of the corresponding Cds1 kinase [17].
  • Rad3-Cds1 mediates coupling of initiation of meiotic recombination with DNA replication. Mei4-dependent transcription as a potential target of meiotic checkpoint [18].


  1. The CDS1 gene encoding CDP-diacylglycerol synthase in Saccharomyces cerevisiae is essential for cell growth. Shen, H., Heacock, P.N., Clancey, C.J., Dowhan, W. J. Biol. Chem. (1996) [Pubmed]
  2. Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Matsuoka, S., Huang, M., Elledge, S.J. Science (1998) [Pubmed]
  3. Checkpoint activation regulates mutagenic translesion synthesis. Kai, M., Wang, T.S. Genes Dev. (2003) [Pubmed]
  4. Meiotic DNA replication checkpoint control in fission yeast. Murakami, H., Nurse, P. Genes Dev. (1999) [Pubmed]
  5. S-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombe. Lindsay, H.D., Griffiths, D.J., Edwards, R.J., Christensen, P.U., Murray, J.M., Osman, F., Walworth, N., Carr, A.M. Genes Dev. (1998) [Pubmed]
  6. Cid1, a fission yeast protein required for S-M checkpoint control when DNA polymerase delta or epsilon is inactivated. Wang, S.W., Toda, T., MacCallum, R., Harris, A.L., Norbury, C. Mol. Cell. Biol. (2000) [Pubmed]
  7. Reduction of CDP-diacylglycerol synthase activity results in the excretion of inositol by Saccharomyces cerevisiae. Shen, H., Dowhan, W. J. Biol. Chem. (1996) [Pubmed]
  8. Regulation of phosphatidylglycerophosphate synthase levels in Saccharomyces cerevisiae. Shen, H., Dowhan, W. J. Biol. Chem. (1998) [Pubmed]
  9. Subcellular and submitochondrial localization of phospholipid-synthesizing enzymes in Saccharomyces cerevisiae. Kuchler, K., Daum, G., Paltauf, F. J. Bacteriol. (1986) [Pubmed]
  10. Enzymes of phosphoinositide synthesis in secretory vesicles destined for the plasma membrane in Saccharomyces cerevisiae. Kinney, A.J., Carman, G.M. J. Bacteriol. (1990) [Pubmed]
  11. Gene cloning and characterization of CDP-diacylglycerol synthase from rat brain. Saito, S., Goto, K., Tonosaki, A., Kondo, H. J. Biol. Chem. (1997) [Pubmed]
  12. Regulation of phospholipid biosynthetic enzymes by the level of CDP-diacylglycerol synthase activity. Shen, H., Dowhan, W. J. Biol. Chem. (1997) [Pubmed]
  13. Saccharomyces cerevisiae mutant with a partial defect in the synthesis of CDP-diacylglycerol and altered regulation of phospholipid biosynthesis. Klig, L.S., Homann, M.J., Kohlwein, S.D., Kelley, M.J., Henry, S.A., Carman, G.M. J. Bacteriol. (1988) [Pubmed]
  14. Regulation of CDP-diacylglycerol synthase activity in Saccharomyces cerevisiae. Homann, M.J., Henry, S.A., Carman, G.M. J. Bacteriol. (1985) [Pubmed]
  15. Coordinate regulation of phospholipid biosynthesis by serine in Saccharomyces cerevisiae. Homann, M.J., Bailis, A.M., Henry, S.A., Carman, G.M. J. Bacteriol. (1987) [Pubmed]
  16. Molecular cloning of the yeast OPI3 gene as a high copy number suppressor of the cho2 mutation. Preitschopf, W., Lückl, H., Summers, E., Henry, S.A., Paltauf, F., Kohlwein, S.D. Curr. Genet. (1993) [Pubmed]
  17. Rad53 kinase activation-independent replication checkpoint function of the N-terminal forkhead-associated (FHA1) domain. Pike, B.L., Tenis, N., Heierhorst, J. J. Biol. Chem. (2004) [Pubmed]
  18. Rad3-Cds1 mediates coupling of initiation of meiotic recombination with DNA replication. Mei4-dependent transcription as a potential target of meiotic checkpoint. Ogino, K., Masai, H. J. Biol. Chem. (2006) [Pubmed]
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