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Gene Review

ACS1  -  acetate--CoA ligase 1

Saccharomyces cerevisiae S288c

Synonyms: Acetate--CoA ligase 1, Acetyl-coenzyme A synthetase 1, Acyl-activating enzyme 1, FUN44, YAL054C
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Disease relevance of ACS1


High impact information on ACS1


Biological context of ACS1


Anatomical context of ACS1

  • No peroxisomal remnants were observed inside vacuoles in the cells of acs1, acs2, acs3 and icl1 mutants after prolonged cultivation in ethanol medium [9].

Associations of ACS1 with chemical compounds


Other interactions of ACS1

  • In a mutant lacking the URS1-binding factor, Ume6p, ACS1 expression was partially glucose insensitive [1].
  • (iv) The sequence ACGTSCRGAATGA was found in the promoters of the partially ethanol-repressed genes ACS1 and YAT1 [14].
  • Gene ICL2 was identified as the structural gene encoding the monomer of ACS [13].

Analytical, diagnostic and therapeutic context of ACS1


  1. Transcriptional control of the yeast acetyl-CoA synthetase gene, ACS1, by the positive regulators CAT8 and ADR1 and the pleiotropic repressor UME6. Kratzer, S., Schüller, H.J. Mol. Microbiol. (1997) [Pubmed]
  2. Applicability of an enzymatic quantitation of methylmalonic, propionic, and acetic acids in normal and megaloblastic states. Frenkel, E.P., Kitchens, R.L. Blood (1977) [Pubmed]
  3. A link between transcription and intermediary metabolism: a role for Sir2 in the control of acetyl-coenzyme A synthetase. Starai, V.J., Takahashi, H., Boeke, J.D., Escalante-Semerena, J.C. Curr. Opin. Microbiol. (2004) [Pubmed]
  4. The two acetyl-coenzyme A synthetases of Saccharomyces cerevisiae differ with respect to kinetic properties and transcriptional regulation. van den Berg, M.A., de Jong-Gubbels, P., Kortland, C.J., van Dijken, J.P., Pronk, J.T., Steensma, H.Y. J. Biol. Chem. (1996) [Pubmed]
  5. Substrate specificity of acetyl coenzyme A synthetase. Patel, S.S., Walt, D.R. J. Biol. Chem. (1987) [Pubmed]
  6. ACS2, a Saccharomyces cerevisiae gene encoding acetyl-coenzyme A synthetase, essential for growth on glucose. Van den Berg, M.A., Steensma, H.Y. Eur. J. Biochem. (1995) [Pubmed]
  7. The Saccharomyces cerevisiae acetyl-coenzyme A synthetase encoded by the ACS1 gene, but not the ACS2-encoded enzyme, is subject to glucose catabolite inactivation. de Jong-Gubbels, P., van den Berg, M.A., Steensma, H.Y., van Dijken, J.P., Pronk, J.T. FEMS Microbiol. Lett. (1997) [Pubmed]
  8. Genetic and physical localization of the acetyl-coenzyme A synthetase gene ACS1 on chromosome I of Saccharomyces cerevisiae. Steensma, H.Y., Barth, G., de Virgilio, C. Yeast (1993) [Pubmed]
  9. Impairment of peroxisome degradation in Pichia methanolica mutants defective in acetyl-CoA synthetase or isocitrate lyase. Kulachkovsky, A.R., Moroz, O.M., Sibirny, A.A. Yeast (1997) [Pubmed]
  10. The acetyl-CoA synthetase gene ACS2 of the yeast Saccharomyces cerevisiae is coregulated with structural genes of fatty acid biosynthesis by the transcriptional activators Ino2p and Ino4p. Hiesinger, M., Wagner, C., Schüller, H.J. FEBS Lett. (1997) [Pubmed]
  11. Adenosine 5'-tetraphosphate and adenosine 5'-pentaphosphate are synthesized by yeast acetyl coenzyme A synthetase. Guranowski, A., Günther Sillero, M.A., Sillero, A. J. Bacteriol. (1994) [Pubmed]
  12. Three target genes for the transcriptional activator Cat8p of Kluyveromyces lactis: acetyl coenzyme A synthetase genes KlACS1 and KlACS2 and lactate permease gene KlJEN1. Lodi, T., Saliola, M., Donnini, C., Goffrini, P. J. Bacteriol. (2001) [Pubmed]
  13. Characterization of mutants of the yeast Yarrowia lipolytica defective in acetyl-coenzyme A synthetase. Kujau, M., Weber, H., Barth, G. Yeast (1992) [Pubmed]
  14. Transient mRNA responses in chemostat cultures as a method of defining putative regulatory elements: application to genes involved in Saccharomyces cerevisiae acetyl-coenzyme A metabolism. van den Berg, M.A., de Jong-Gubbels, P., Steensma, H.Y. Yeast (1998) [Pubmed]
  15. Characterization of two members (ACS1 and ACS3) of the 1-aminocyclopropane-1-carboxylate synthase gene family of Arabidopsis thaliana. Liang, X., Oono, Y., Shen, N.F., Köhler, C., Li, K., Scolnik, P.A., Theologis, A. Gene (1995) [Pubmed]
  16. Studies on the "aerobic" acetyl-coenzyme A synthetase of Saccharomyces cerevisiae: purification, crystallization, and physical properties of the enzyme. Satyanarayana, T., Klein, H.P. Arch. Biochem. Biophys. (1976) [Pubmed]
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