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MeSH Review

Pneumonia, Pneumocystis

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Disease relevance of Pneumonia, Pneumocystis


High impact information on Pneumonia, Pneumocystis


Chemical compound and disease context of Pneumonia, Pneumocystis

  • The majority of sera tested from humans with diagnosed pneumocystosis and from rats allowed to recover from steroid-induced pneumocystosis reacted strongly with 110,000- to 116,000-, and 55,000- to 60,000-MW components [10].
  • Role of clindamycin with or without another agent for treatment of pneumocystosis in patients with AIDS [11].
  • Furazolidone exhibited only slight activity as a prophylactic agent but was moderately effective in the therapy of pneumocystosis [12].
  • Inhibitors of folic acid synthesis were compared alone and in different combinations in the therapy of pneumocystosis in immunosuppressed rats [13].
  • Serendipitous availability of a normal premorbid lung gallium scan indicated that pneumocystosis had developed during aerosol pentamidine prophylaxis; at the time of presentation a repeat gallium scan indicated disease limited to the upper lobes [14].

Biological context of Pneumonia, Pneumocystis


Anatomical context of Pneumonia, Pneumocystis


Gene context of Pneumonia, Pneumocystis


Analytical, diagnostic and therapeutic context of Pneumonia, Pneumocystis

  • This study evaluated the efficacy of terbinafine on rat P. carinii antigenic profile and the immune response by Western blot analysis, in comparison with atovaquone and co-trimoxazole in rats with pneumocystosis [25].
  • Extrapulmonary pneumocystosis is a feature of severe immunosuppression which earlier reports have suggested is limited to patients receiving either no prophylaxis or aerosolised pentamidine [26].
  • Immunoblotting studies using rat-P. carinii antigen showed that 116-kDa antigen reacted with the antirat-P. carinii serum and sera from rnu/+ rats but not with the antimouse-P. carinii serum and the serum from a human with pneumocystosis, whereas 52-kDa antigens of rat-P. carinii were recognized by all the anti-P. carinii sera tested [27].


  1. Infections in patients with chronic lymphocytic leukemia treated with fludarabine. Anaissie, E.J., Kontoyiannis, D.P., O'Brien, S., Kantarjian, H., Robertson, L., Lerner, S., Keating, M.J. Ann. Intern. Med. (1998) [Pubmed]
  2. Autopsy-proven causes of death in HIV-infected patients treated for tuberculosis in Abidjan, Côte d'Ivoire. Greenberg, A.E., Lucas, S., Tossou, O., Coulibaly, I.M., Coulibaly, D., Kassim, S., Ackah, A., De Cock, K.M. AIDS (1995) [Pubmed]
  3. Combination of PS-15, epiroprim, or pyrimethamine with dapsone in prophylaxis of Toxoplasma gondii and Pneumocystis carinii dual infection in a rat model. Brun-Pascaud, M., Chau, F., Garry, L., Jacobus, D., Derouin, F., Girard, P.M. Antimicrob. Agents Chemother. (1996) [Pubmed]
  4. Role of desensitisation for drug hypersensitivity in patients with HIV infection. Carr, A. Drug safety : an international journal of medical toxicology and drug experience. (1997) [Pubmed]
  5. Disseminated pneumocystosis without pulmonary involvement during prophylactic aerosolized pentamidine therapy in a patient with the acquired immunodeficiency syndrome. DeRoux, S.J., Adsay, N.V., Ioachim, H.L. Arch. Pathol. Lab. Med. (1991) [Pubmed]
  6. Regulation of surfactant phosphatidylcholine secretion from alveolar type II cells during Pneumocystis carinii pneumonia in the rat. Rice, W.R., Singleton, F.M., Linke, M.J., Walzer, P.D. J. Clin. Invest. (1993) [Pubmed]
  7. Extrapulmonary pneumocystosis in patients taking aerosolised pentamidine. Northfelt, D.W. Lancet (1989) [Pubmed]
  8. Extrapulmonary pneumocystosis: clinical features in human immunodeficiency virus infection. Northfelt, D.W., Clement, M.J., Safrin, S. Medicine (Baltimore) (1990) [Pubmed]
  9. Use of terbinafine in mouse and rat models of Pneumocystis carinii pneumonia. Walzer, P.D., Ashbaugh, A. Antimicrob. Agents Chemother. (2002) [Pubmed]
  10. Analyses of rat Pneumocystis carinii antigens recognized by human and rat antibodies by using western immunoblotting. Graves, D.C., McNabb, S.J., Worley, M.A., Downs, T.D., Ivey, M.H. Infect. Immun. (1986) [Pubmed]
  11. Role of clindamycin with or without another agent for treatment of pneumocystosis in patients with AIDS. Vildé, J.L., Remington, J.S. J. Infect. Dis. (1992) [Pubmed]
  12. Furazolidone and nitrofurantoin in the treatment of experimental Pneumocystis carinii pneumonia. Walzer, P.D., Kim, C.K., Foy, J., Zhang, J.L. Antimicrob. Agents Chemother. (1991) [Pubmed]
  13. Inhibitors of folic acid synthesis in the treatment of experimental Pneumocystis carinii pneumonia. Walzer, P.D., Kim, C.K., Foy, J.M., Linke, M.J., Cushion, M.T. Antimicrob. Agents Chemother. (1988) [Pubmed]
  14. Relapse of Pneumocystis carinii pneumonia in the upper lobes during aerosol pentamidine prophylaxis. Bradburne, R.M., Ettensohn, D.B., Opal, S.M., McCool, F.D. Thorax (1989) [Pubmed]
  15. Pneumocystis jirovecii dihydropteroate synthase genotypes in French patients with pneumocystosis: a 1998-2001 prospective study. Latouche, S., Lacube, P., Maury, E., Bolognini, J., Develoux, M., Girard, P.M., Godet, C., Lebrette, M.G., Mayaud, C., Guillot, J., Roux, P. Med. Mycol. (2003) [Pubmed]
  16. Aerosolised pentamidine for Pneumocystis carinii pneumonia in patients with acquired immunodeficiency syndrome. Weinberg, A., Dantonio, S.A., Duarte, M.I., Pedreira Júnior, W.L., Barone, A.A., Ishioka, S. Rev. Inst. Med. Trop. Sao Paulo (1990) [Pubmed]
  17. Pneumocystis carinii thyroiditis. Report of three cases and review of the literature. Guttler, R., Singer, P.A., Axline, S.G., Greaves, T.S., McGill, J.J. Arch. Intern. Med. (1993) [Pubmed]
  18. Pneumocystis carinii stimulates in vitro production of tumor necrosis factor-alpha by human macrophages. Tamburrini, E., De Luca, A., Ventura, G., Maiuro, G., Siracusano, A., Ortona, E., Antinori, A. Med. Microbiol. Immunol. (Berl.) (1991) [Pubmed]
  19. Therapy and prophylaxis of Pneumocystis carinii pneumonia. Dutz, W., Post, C., Jennings-Khodadad, E., Fakouhi, T., Kohout, E., Bandarizadeh, B. National Cancer Institute monograph. (1976) [Pubmed]
  20. Glycoproteins composed of major surface immunodeterminants of Pneumocystis carinii. Tanabe, K., Takasaki, S., Watanabe, J., Kobata, A., Egawa, K., Nakamura, Y. Infect. Immun. (1989) [Pubmed]
  21. Synergistic combinations of Ro 11-8958 and other dihydrofolate reductase inhibitors with sulfamethoxazole and dapsone for therapy of experimental pneumocystosis. Walzer, P.D., Foy, J., Steele, P., White, M. Antimicrob. Agents Chemother. (1993) [Pubmed]
  22. Hepatic pneumocystosis without concomitant PCP in a patient with AIDS. Sarmento e Castro, R., Vasconcelos, O., Carneiro, F., Rocha-Marques, A. J. Infect. (1997) [Pubmed]
  23. Severe pulmonary pneumocystosis in simian acquired immunodeficiency syndrome induced by simian immunodeficiency virus: its characterization by the polymerase-chain-reaction method and failure of experimental transmission to immunodeficient animals. Furuta, T., Fujita, M., Mukai, R., Sakakibara, I., Sata, T., Miki, K., Hayami, M., Kojima, S., Yoshikawa, Y. Parasitol. Res. (1993) [Pubmed]
  24. PCR in diagnosis of pneumocystosis of rats. Hong, S.T. Korean J. Parasitol. (1996) [Pubmed]
  25. Structural changes in rat Pneumocystis carinii surface antigens after terbinafine administration in experimental P. carinii pneumonia. Contini, C., Angelici, E., Canipari, R. J. Antimicrob. Chemother. (1999) [Pubmed]
  26. Systemic Pneumocystis carinii pneumonia prophylaxis with dapsone and pyrimethamine fails to protect against extrapulmonary pneumocystosis. Carlin, E.M., Coker, R.J., Goldin, R.D., Harris, J.R. Genitourinary medicine. (1993) [Pubmed]
  27. Fatal spontaneous pneumocystosis in nude rats. Furuta, T., Fujita, M., Machii, K., Kobayashi, K., Kojima, S., Ueda, K. Lab. Anim. Sci. (1993) [Pubmed]
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