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Chemical Compound Review

AR-1D8597     2-[[4-[2-[2-(2-acetamido- 4,5,6-trihydroxy...

Synonyms: AC1L3OY2, AC1Q5S7D, 64374-58-9, Murnac-tripeptide, Ac-Mur-L-ala-gamma-D-gln-meso-A(2)pm, ...
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Disease relevance of Muramyl tripeptide


High impact information on Muramyl tripeptide


Chemical compound and disease context of Muramyl tripeptide


Biological context of Muramyl tripeptide


Anatomical context of Muramyl tripeptide


Associations of Muramyl tripeptide with other chemical compounds


Gene context of Muramyl tripeptide


Analytical, diagnostic and therapeutic context of Muramyl tripeptide


  1. Protection of mice against fatal herpes simplex type 2 infection by liposomes containing muramyl tripeptide. Koff, W.C., Showalter, S.D., Hampar, B., Fidler, I.J. Science (1985) [Pubmed]
  2. Therapy for osteosarcoma in dogs with intravenous injection of liposome-encapsulated muramyl tripeptide. MacEwen, E.G., Kurzman, I.D., Rosenthal, R.C., Smith, B.W., Manley, P.A., Roush, J.K., Howard, P.E. J. Natl. Cancer Inst. (1989) [Pubmed]
  3. Modulation of monocyte functions by muramyl tripeptide phosphatidylethanolamine in a phase II study in patients with metastatic melanoma. Liebes, L., Walsh, C.M., Chachoua, A., Oratz, R., Richards, D., Hochster, H., Peace, D., Marino, D., Alba, S., Le Sher, D. J. Natl. Cancer Inst. (1992) [Pubmed]
  4. Treatment of experimental lung metastasis with local thoracic irradiation followed by systemic macrophage activation with liposomes containing muramyl tripeptide. Saiki, I., Milas, L., Hunter, N., Fidler, I.J. Cancer Res. (1986) [Pubmed]
  5. Free versus liposome-encapsulated muramyl tripeptide phosphatidylethanolamide in treatment of experimental Klebsiella pneumoniae infection. Melissen, P.M., van Vianen, W., Rijsbergen, Y., Bakker-Woudenberg, I.A. Infect. Immun. (1992) [Pubmed]
  6. In vitro and in vivo effect of doxorubicin combined with liposome-encapsulated muramyl tripeptide on canine monocyte activation. Shi, F., MacEwen, E.G., Kurzman, I.D. Cancer Res. (1993) [Pubmed]
  7. Phase I and immunomodulatory study of a muramyl peptide, muramyl tripeptide phosphatidylethanolamine. Urba, W.J., Hartmann, L.C., Longo, D.L., Steis, R.G., Smith, J.W., Kedar, I., Creekmore, S., Sznol, M., Conlon, K., Kopp, W.C. Cancer Res. (1990) [Pubmed]
  8. Human peptidoglycan recognition protein-L is an N-acetylmuramoyl-L-alanine amidase. Wang, Z.M., Li, X., Cocklin, R.R., Wang, M., Wang, M., Fukase, K., Inamura, S., Kusumoto, S., Gupta, D., Dziarski, R. J. Biol. Chem. (2003) [Pubmed]
  9. Synergism between human monocyte chemotactic and activating factor and bacterial products for activation of tumoricidal properties in murine macrophages. Singh, R.K., Berry, K., Matsushima, K., Yasumoto, K., Fidler, I.J. J. Immunol. (1993) [Pubmed]
  10. Osteosarcoma: a randomized, prospective trial of the addition of ifosfamide and/or muramyl tripeptide to cisplatin, doxorubicin, and high-dose methotrexate. Meyers, P.A., Schwartz, C.L., Krailo, M., Kleinerman, E.S., Betcher, D., Bernstein, M.L., Conrad, E., Ferguson, W., Gebhardt, M., Goorin, A.M., Harris, M.B., Healey, J., Huvos, A., Link, M., Montebello, J., Nadel, H., Nieder, M., Sato, J., Siegal, G., Weiner, M., Wells, R., Wold, L., Womer, R., Grier, H. J. Clin. Oncol. (2005) [Pubmed]
  11. Activation of cytolytic activity in peripheral blood monocytes of renal cancer patients against non-cultured autologous tumor cells. Galligioni, E., Quaia, M., Spada, A., Favaro, D., Santarosa, M., Talamini, R., Monfardini, S. Int. J. Cancer (1993) [Pubmed]
  12. Therapeutic efficacy of liposome-encapsulated ribavirin and muramyl tripeptide in experimental infection with influenza or herpes simplex virus. Gangemi, J.D., Nachtigal, M., Barnhart, D., Krech, L., Jani, P. J. Infect. Dis. (1987) [Pubmed]
  13. Unique histological changes in lung metastases of osteosarcoma patients following therapy with liposomal muramyl tripeptide (CGP 19835A lipid). Kleinerman, E.S., Raymond, A.K., Bucana, C.D., Jaffe, N., Harris, M.B., Krakoff, I.H., Benjamin, R., Fidler, I.J. Cancer Immunol. Immunother. (1992) [Pubmed]
  14. Induction and maintenance of monocyte cytotoxicity during treatment with liposomes containing muramyl tripeptide despite tachyphylaxis to the cytokine response. Galligioni, E., Favaro, D., Santarosa, M., Quaia, M., Spada, A., Freschi, A., Alberti, D. Clin. Cancer Res. (1995) [Pubmed]
  15. Inhibition of bacterial translocation in obstructive jaundice by muramyl tripeptide phosphatidylethanolamine in the rat. Ding, J.W., Andersson, R., Soltesz, V.L., Pärsson, H., Johansson, K., Wang, W., Bengmark, S. J. Hepatol. (1994) [Pubmed]
  16. Liposomal muramyl tripeptide up-regulates interleukin-1 alpha, interleukin-1 beta, tumor necrosis factor-alpha, interleukin-6 and interleukin-8 gene expression in human monocytes. Asano, T., McWatters, A., An, T., Matsushima, K., Kleinerman, E.S. J. Pharmacol. Exp. Ther. (1994) [Pubmed]
  17. Stimulant effect of the immunomodulator MTP-PE on proliferation of monocytic cells in the guinea pig. Wachsmuth, E.D., Huber, J. Virchows Arch., B, Cell Pathol. (1989) [Pubmed]
  18. Roles of peripheral leukocytes and tissue macrophages in antibacterial resistance induced by free or liposome-encapsulated muramyl tripeptide phosphatidylethanolamide. Melissen, P.M., van Vianen, W., Bakker-Woudenberg, I.A. Infect. Immun. (1992) [Pubmed]
  19. Involvement of T cells in enhanced resistance to Klebsiella pneumoniae septicemia in mice treated with liposome-encapsulated muramyl tripeptide phosphatidylethanolamine or gamma interferon. ten Hagen, T.L., van Vianen, W., Savelkoul, H.F., Heremans, H., Buurman, W.A., Bakker-Woudenberg, I.A. Infect. Immun. (1998) [Pubmed]
  20. The in situ activation of cytotoxic properties in murine Kupffer cells by the systemic administration of whole Mycobacterium bovis organisms or muramyl tripeptide. Xu, Z., Fidler, I.J. Cancer Immunol. Immunother. (1984) [Pubmed]
  21. Testing of Plasmodium vivax CS proteins in Saimiri monkeys. Collins, W.E. Bull. World Health Organ. (1990) [Pubmed]
  22. Activation of tumoricidal properties in monocytes from cancer patients following intravenous administration of liposomes containing muramyl tripeptide phosphatidylethanolamine. Kleinerman, E.S., Murray, J.L., Snyder, J.S., Cunningham, J.E., Fidler, I.J. Cancer Res. (1989) [Pubmed]
  23. Lack of production of interleukin 1 by human blood monocytes activated to the antitumor state by liposome-encapsulated muramyl tripeptide. Tandon, P., Utsugi, T., Sone, S. Cancer Res. (1986) [Pubmed]
  24. Activation of tumoricidal properties in human blood monocytes by liposomes containing lipophilic muramyl tripeptide. Kleinerman, E.S., Erickson, K.L., Schroit, A.J., Fogler, W.E., Fidler, I.J. Cancer Res. (1983) [Pubmed]
  25. Enhancement of nonspecific resistance by liposome-encapsulated immunomodulators does not affect skin graft rejection in mice. ten Hagen, T.L., Vossen, A.C., van Vianen, W., Tibbe, G.J., Savelkoul, H.F., Heremans, H., Bakker-Woudenberg, I.A. Transplantation (1995) [Pubmed]
  26. Fate of two 14C labelled muramyl peptides: Ac-Mur-L-Ala-gamma-D-Glu-meso-A2pm and Ac-Mur-L-Ala-gamma-D-Glu-meso-A2pm-D-Ala-D-Ala in mice. Evaluation of their ability to increase non specific resistance to Klebsiella infection. Yapo, A., Petit, J.F., Lederer, E., Parant, M., Parant, F., Chedid, L. Int. J. Immunopharmacol. (1982) [Pubmed]
  27. Upregulation of interferon-induced indoleamine 2,3-dioxygenase in human macrophage cultures by lipopolysaccharide, muramyl tripeptide, and interleukin-1. Hissong, B.D., Byrne, G.I., Padilla, M.L., Carlin, J.M. Cell. Immunol. (1995) [Pubmed]
  28. Soluble intercellular adhesion molecule-1 and serum cytokines in melanoma patients treated with liposomes containing muramyl tripeptide. Favaro, D., Santarosa, M., Quaia, M., Spada, A., Freschi, A., Talamini, R., Galligioni, E. Tumori. (1995) [Pubmed]
  29. Crystal structure of human peptidoglycan recognition protein I{alpha} bound to a muramyl pentapeptide from Gram-positive bacteria. Guan, R., Brown, P.H., Swaminathan, C.P., Roychowdhury, A., Boons, G.J., Mariuzza, R.A. Protein Sci. (2006) [Pubmed]
  30. Activation of macrophages to express cytocidal activity correlates with inhibition of their responsiveness to macrophage colony-stimulating factor (CSF-1): involvement of a pertussis toxin-sensitive reaction. Hume, D.A., Denkins, Y.M. Immunol. Cell Biol. (1989) [Pubmed]
  31. Crystal structure of a peptidoglycan recognition protein (PGRP) in complex with a muramyl tripeptide from Gram-positive bacteria. Guan, R., Roychowdury, A., Ember, B., Kumar, S., Boons, G.J., Mariuzza, R.A. J. Endotoxin Res. (2005) [Pubmed]
  32. Influence of chemotherapy administration on monocyte activation by liposomal muramyl tripeptide phosphatidylethanolamine in children with osteosarcoma. Kleinerman, E.S., Snyder, J.S., Jaffe, N. J. Clin. Oncol. (1991) [Pubmed]
  33. Prevention of chemotherapy- or X-irradiation-induced monocytopenia by oral administration of lipophilic muramyl tripeptide. Killion, J.J., Brown, D.R., Wilson, M.R., Lloyd, M.M., Fidler, I.J. Oncol. Res. (1994) [Pubmed]
  34. Muramyl tripeptide: an effective immunotherapy in the surgical setting for pediatric abdominal neoplasms. Jarowenko, D.G., Sigler, S.C., Pellis, N.R. J. Pediatr. Surg. (1987) [Pubmed]
  35. Biologic therapy for osteosarcoma using liposome-encapsulated muramyl tripeptide. Kleinerman, E.S. Hematol. Oncol. Clin. North Am. (1995) [Pubmed]
  36. Direct chemiluminescence immunoassay (CLIA) for muramyl tripeptide phosphatidyl-ethanolamine in plasma. Gay, B., Towbin, H., Schnell, C., Einsle, K., Graf, P., Gygax, D. J. Biolumin. Chemilumin. (1991) [Pubmed]
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