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Gene Review

SH2D2A  -  SH2 domain containing 2A

Homo sapiens

Synonyms: F2771, SCAP, SH2 domain-containing adapter protein, SH2 domain-containing protein 2A, T cell-specific adapter protein, ...
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Disease relevance of SH2D2A


High impact information on SH2D2A

  • Here, we demonstrate that a substantial fraction of TSAd is found in the T cell nucleus [4].
  • Further, we show that this augmentation requires a functional TSAd SH2 domain [4].
  • Furthermore, the TSAd SH2 domain appears to be essential for this transcription-activating function independent of its role in nuclear import [4].
  • Consistent with a role as a transcription activator, cotransfection of TSAd with an IL-2 promoter-reporter gene construct results in a considerable upregulation of IL-2 promoter activity [4] ,[5].

Biological context of SH2D2A


Anatomical context of SH2D2A


Associations of SH2D2A with chemical compounds


Regulatory relationships of SH2D2A


Other interactions of SH2D2A


Analytical, diagnostic and therapeutic context of SH2D2A

  • Consistent with this observation, we found that a cAMP analog was a very potent inducer of SH2D2A mRNA expression in primary T cells as measured by real-time RT-PCR [7].
  • Unlike control and SCAP transfected cells, CCTalpha in SRD 4 cells was localized by immunofluorescence to the nuclear envelope, suggesting that residual enzyme activity in these cells was in an active membrane-associated form [13].
  • We have isolated its rat homologue ( rSH2D2A) from an NK cell cDNA library and mapped the corresponding gene to chromosome 2 with a hamster-rat radiation hybrid cell panel. rSH2D2A encodes a 376 amino acid protein (rTSAd) which shows greater homology to mouse than human TSAd [8].


  1. Genetic association between juvenile rheumatoid arthritis and polymorphism in the SH2D2A gene. Smerdel, A., Dai, K.Z., Lorentzen, A.R., Flatø, B., Maslinski, S., Thorsby, E., Førre, Ø., Spurkland, A. Genes Immun. (2004) [Pubmed]
  2. VRAP is an adaptor protein that binds KDR, a receptor for vascular endothelial cell growth factor. Wu, L.W., Mayo, L.D., Dunbar, J.D., Kessler, K.M., Ozes, O.N., Warren, R.S., Donner, D.B. J. Biol. Chem. (2000) [Pubmed]
  3. The emerging role of the T cell-specific adaptor (TSAd) protein as an autoimmune disease-regulator in mouse and man. Marti, F., Lapinski, P.E., King, P.D. Immunol. Lett. (2005) [Pubmed]
  4. A transcription function for the T cell-specific adapter (TSAd) protein in T cells: critical role of the TSAd Src homology 2 domain. Marti, F., Post, N.H., Chan, E., King, P.D. J. Exp. Med. (2001) [Pubmed]
  5. Outpatient treatment with subcutaneous interleukin-2 and interferon alfa administration in combination with fluorouracil in patients with metastatic renal cell carcinoma: results of a sequential nonrandomized phase II study. Subcutaneous Administration Propeukin Program Cooperative Group. Tourani, J.M., Pfister, C., Berdah, J.F., Benhammouda, A., Salze, P., Monnier, A., Paule, B., Guillet, P., Chretien, Y., Brewer, Y., Di Palma, M., Untereiner, M., Malaurie, E., Tadrist, Z., Pavlovitch, J.M., Hauteville, D., Mejean, A., Azagury, M., Mayeur, D., Lucas, V., Krakowski, I., Larregain-Fournier, D., Abourachid, H., Andrieu, J.M., Chastang, C. J. Clin. Oncol. (1998) [Pubmed]
  6. The SH2D2A gene encoding the T-cell-specific adapter protein (TSAd) is localized centromeric to the CD1 gene cluster on human Chromosome 1. Dai, K.Z., Vergnaud, G., Ando, A., Inoko, H., Spurkland, A. Immunogenetics (2000) [Pubmed]
  7. Transcriptional activation of the SH2D2A gene is dependent on a cyclic adenosine 5'-monophosphate-responsive element in the proximal SH2D2A promoter. Dai, K.Z., Johansen, F.E., Kolltveit, K.M., Aasheim, H.C., Dembic, Z., Vartdal, F., Spurkland, A. J. Immunol. (2004) [Pubmed]
  8. cDNA cloning of a rat orthologue of SH2D2A encoding T-cell-specific adaptor protein (TSAd): expression in T and NK cells. Nejad, S., Bryceson, Y., Dissen, E., Sundvold-Gjerstad, V., Naper, C., Rolstad, B., Spurkland, A., Vaage, J.T. Immunogenetics (2004) [Pubmed]
  9. Molecular cloning of a T cell-specific adapter protein (TSAd) containing an Src homology (SH) 2 domain and putative SH3 and phosphotyrosine binding sites. Spurkland, A., Brinchmann, J.E., Markussen, G., Pedeutour, F., Munthe, E., Lea, T., Vartdal, F., Aasheim, H.C. J. Biol. Chem. (1998) [Pubmed]
  10. Structure function analysis of SH2D2A isoforms expressed in T cells reveals a crucial role for the proline rich region encoded by SH2D2A exon 7. Granum, S., Sundvold-Gjerstad, V., Dai, K.Z., Kolltveit, K.M., Hildebrand, K., Huitfeldt, H.S., Lea, T., Spurkland, A. BMC Immunol. (2006) [Pubmed]
  11. The T cell regulator gene SH2D2A contributes to the genetic susceptibility of multiple sclerosis. Dai, K.Z., Harbo, H.F., Celius, E.G., Oturai, A., Sørensen, P.S., Ryder, L.P., Datta, P., Svejgaard, A., Hillert, J., Fredrikson, S., Sandberg-Wollheim, M., Laaksonen, M., Myhr, K.M., Nyland, H., Vartdal, F., Spurkland, A. Genes Immun. (2001) [Pubmed]
  12. HSH2: a novel SH2 domain-containing adapter protein involved in tyrosine kinase signaling in hematopoietic cells. Oda, T., Muramatsu, M.A., Isogai, T., Masuho, Y., Asano, S., Yamashita, T. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  13. Regulation of phosphatidylcholine metabolism in Chinese hamster ovary cells by the sterol regulatory element-binding protein (SREBP)/SREBP cleavage-activating protein pathway. Lagace, T.A., Storey, M.K., Ridgway, N.D. J. Biol. Chem. (2000) [Pubmed]
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