The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

N  -  nucleocapsid protein

Human parainfluenza virus 1

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of N

  • The 3' untranslated sequence of the HeV N gene mRNA was 568 nt and was much longer than that observed in other Paramyxovirinae [1].
  • The x-ray structures of a murine MHC class I molecule (H-2Kb) were determined in complex with two different viral peptides, derived from the vesicular stomatitis virus nucleoprotein (52-59), VSV-8, and the Sendai virus nucleoprotein (324-332), SEV-9 [2].
  • A single peptide derived from the Sendai virus nucleoprotein (NP(324-332)) binds to both H-2 Kb and Db MHC class I molecules, generating both immunodominant (NP(324-332)/Kb) and subdominant (NP(324-332)/Db) epitopes [3].
  • Human parainfluenza virus type 1 matrix and nucleoprotein genes transiently expressed in mammalian cells induce the release of virus-like particles containing nucleocapsid-like structures [4].
  • Inhibition of IFN production by the arenavirus NP is likely to be a determinant of virulence in vivo [5].

High impact information on N

  • Dynamic control of interferon-beta (IFN-beta) gene expression requires the regulated assembly and disassembly of the enhanceosome, a higher-order nucleoprotein complex formed in response to virus infection [6].
  • Here, we show that presentation on Db of ASNENMETM, a peptide from influenza nucleoprotein, and on Kb of FAPGNYPAL, a peptide from Sendai virus nucleoprotein, was blocked by the proteasome inhibitor, lactacystin [7].
  • Inhibition of the type I interferon response by the nucleoprotein of the prototypic arenavirus lymphocytic choriomeningitis virus [5].
  • Using expression plasmids encoding individual LCMV proteins, we found that expression of the LCMV nucleoprotein (NP) was sufficient to inhibit both IFN production and nuclear translocation of IRF-3 [5].
  • To initiate an investigation of the genetic basis of the attenuation of BPIV3 in primates, we produced viable chimeric HPIV3 recombinants containing the nucleoprotein (N) open reading frame (ORF) from either BPIV3 Ka or SF in place of the HPIV3 N ORF [8].

Chemical compound and disease context of N


Biological context of N


Anatomical context of N


Analytical, diagnostic and therapeutic context of N


  1. Sequence analysis of the Hendra virus nucleoprotein gene: comparison with other members of the subfamily Paramyxovirinae. Yu, M., Hansson, E., Shiell, B., Michalski, W., Eaton, B.T., Wang, L.F. J. Gen. Virol. (1998) [Pubmed]
  2. Crystal structures of two viral peptides in complex with murine MHC class I H-2Kb. Fremont, D.H., Matsumura, M., Stura, E.A., Peterson, P.A., Wilson, I.A. Science (1992) [Pubmed]
  3. Efficient priming of CD8+ memory T cells specific for a subdominant epitope following Sendai virus infection. Cole, G.A., Hogg, T.L., Coppola, M.A., Woodland, D.L. J. Immunol. (1997) [Pubmed]
  4. Human parainfluenza virus type 1 matrix and nucleoprotein genes transiently expressed in mammalian cells induce the release of virus-like particles containing nucleocapsid-like structures. Coronel, E.C., Murti, K.G., Takimoto, T., Portner, A. J. Virol. (1999) [Pubmed]
  5. Inhibition of the type I interferon response by the nucleoprotein of the prototypic arenavirus lymphocytic choriomeningitis virus. Martínez-Sobrido, L., Zúñiga, E.I., Rosario, D., García-Sastre, A., de la Torre, J.C. J. Virol. (2006) [Pubmed]
  6. Coordination of a transcriptional switch by HMGI(Y) acetylation. Munshi, N., Agalioti, T., Lomvardas, S., Merika, M., Chen, G., Thanos, D. Science (2001) [Pubmed]
  7. Distinct proteolytic processes generate the C and N termini of MHC class I-binding peptides. Mo, X.Y., Cascio, P., Lemerise, K., Goldberg, A.L., Rock, K. J. Immunol. (1999) [Pubmed]
  8. A recombinant human parainfluenza virus type 3 (PIV3) in which the nucleocapsid N protein has been replaced by that of bovine PIV3 is attenuated in primates. Bailly, J.E., McAuliffe, J.M., Durbin, A.P., Elkins, W.R., Collins, P.L., Murphy, B.R. J. Virol. (2000) [Pubmed]
  9. Detection of nucleoprotein gene of Sendai virus in the lungs of rats by touchdown nested reverse transcription polymerase chain reaction. Hayase, Y., Tobita, K., Kii, M., Hakamada, Y., Arai, T. Exp. Anim. (1997) [Pubmed]
  10. Paramyxovirus RNA editing and the requirement for hexamer genome length. Hausmann, S., Jacques, J.P., Kolakofsky, D. RNA (1996) [Pubmed]
  11. The nucleoproteins of human parainfluenza virus type 1 and Sendai virus share amino acid sequences and antigenic and structural determinants. Lyn, D., Gill, D.S., Scroggs, R.A., Portner, A. J. Gen. Virol. (1991) [Pubmed]
  12. Immunological interrelationships among human and non-human paramyxoviruses revealed by immunoprecipitation. Ito, Y., Tsurudome, M., Hishiyama, M., Yamada, A. J. Gen. Virol. (1987) [Pubmed]
  13. Acute laryngotracheitis in the rat induced by Sendai virus: the influx of six different types of immunocompetent cells into the laryngeal mucosa differs strongly between the subglottic and the glottic compartment. Jecker, P., McWilliam, A., Marsh, A., Holt, P.G., Mann, W.J., Pabst, R., Westermann, J. Laryngoscope (2001) [Pubmed]
  14. Inflammatory infiltration of the upper airway epithelium during Sendai virus infection: involvement of epithelial dendritic cells. McWilliam, A.S., Marsh, A.M., Holt, P.G. J. Virol. (1997) [Pubmed]
  15. Viral cross-reactivity and antigenic determinants recognized by human parainfluenza virus type 1-specific cytotoxic T-cells. Dave, V.P., Allan, J.E., Slobod, K.S., Smith, F.S., Ryan, K.W., Takimoto, T., Power, U.F., Portner, A., Hurwitz, J.L. Virology (1994) [Pubmed]
  16. The structural proteins of a porcine paramyxovirus (LPMV). Sundqvist, A., Berg, M., Hernandez-Jauregui, P., Linné, T., Moreno-López, J. J. Gen. Virol. (1990) [Pubmed]
  17. Induction of CD8+ T cell responses to dominant and subdominant epitopes and protective immunity to Sendai virus infection by DNA vaccination. Chen, Y., Webster, R.G., Woodland, D.L. J. Immunol. (1998) [Pubmed]
  18. Sequence analysis and expression of the human parainfluenza type 1 virus nucleoprotein gene. Matsuoka, Y., Ray, R. Virology (1991) [Pubmed]
  19. Molecular relationships between human parainfluenza virus type 2, and simian viruses 41 and 5: determination of nucleoprotein gene sequences of simian viruses 41 and 5. Tsurudome, M., Oki, N., Higuchi, Y., Miyahara, K., Yoshimoto, M., Mutsuga, N., Kitada, S., Ogawa, M., Miyahara, Y., Okamoto, K. J. Gen. Virol. (1991) [Pubmed]
  20. Antibodies to paramyxovirus nucleoproteins define regions important for immunogenicity and nucleocapsid assembly. Ryan, K.W., Portner, A., Murti, K.G. Virology (1993) [Pubmed]
WikiGenes - Universities