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Chemical Compound Review

Sulfosate     2-(phosphonomethylamino) ethanoate;...

Synonyms: SULPHOSATE, AG-H-51214, SC-0224, AC1L2XXW, CTK3E9880, ...
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Disease relevance of Roundup

  • Rapid diagnosis of respiratory Chlamydia pneumoniae infection by nested touchdown polymerase chain reaction compared with culture and antigen detection by EIA [1].
  • METHODS: In the stage 1 study respiratory specimens from 42 patients with steady state chronic bronchitis were analysed for Gram staining, sputum culture, and C pneumoniae DNA detection by nested touchdown polymerase chain reaction (PCR) [2].
  • On declines, only the forelimbs were more protracted at touchdown; forelimbs supported the great majority of body weight while they generated nearly all of the braking impulse and, despite the disparity in fore- vs hindlimb function on the decline, mu(req) was not significantly different between limbs [3].
  • The extension velocity at touchdown and the reduction in peak flexion velocity during the yield component of the stance phase may reduce the ability of the limb to absorb impact forces and lead to the development of osteoarthritis of the knee.(ABSTRACT TRUNCATED AT 250 WORDS)[4]
  • It is suggested that the reduced sensation and the decreased evoked potentials after touchdown may be due to occlusion or masking by concomitant afferent input from the feet [5].

High impact information on Roundup


Biological context of Roundup

  • Touchdown enzyme time release-PCR for detection and identification of Chlamydia trachomatis, C. pneumoniae, and C. psittaci using the 16S and 16S-23S spacer rRNA genes [10].
  • A partial DNA sequence of this product was used to design a specific primer pair, which generated a single 864-bp fragment with DNA from 90 of 100 A. fumigatus isolates when a "touchdown" (65-->55 degrees C) annealing protocol was used [11].
  • Calcaneal to vertical touchdown angle, and maximum supination velocity were significant rearfoot movement discriminators [12].
  • Biomechanical variables that demonstrated significantly lower values for the injury free group were the vertical force impact peak and the maximal vertical loading rate, with the maximal rate of rearfoot pronation and the touchdown supination angle showing a trend toward being greater in the injury free group [13].
  • In the current study, we investigated the real-time kinetics of ASPCR and found that a simple touchdown thermocycling protocol improved its specificity significantly [14].

Anatomical context of Roundup

  • Sputum, throat, and nasopharyngeal samples were obtained and analyzed by nested touchdown polymerase chain reaction (PCR), EIA, and culture in Hep-2 and McCoy cells [1].
  • The relative subtalar joint and talocural joint angles at touchdown were varied, and each subject-specific simulation was exposed to a set of perturbed floor conditions [15].
  • Upon the touchdown, the coactivation of the muscles acting around the ankle joint was greatest in the control jump [16].
  • The muscles of the lower extremities are capable of stabilizing the tibiotalar and the talonavicular joints actively, restricting their maximal motion by means of a higher activation before and after touchdown [17].
  • Multiple regression analysis showed that the SEC stiffness during the transmission phase of the knee joint can be explained by a combination of the pre-activity of the VL muscle and the knee joint angular velocity at touchdown (F = 5.76, P < 0.05) [18].

Associations of Roundup with other chemical compounds


Gene context of Roundup


Analytical, diagnostic and therapeutic context of Roundup

  • At multi-detector row CT, 76% (28 of 37) of all distal bypass touchdown segments were identified, but at coronary angiography, only 70% (26 of 37) were identified [26].
  • To assess hindlimb position at the moment of forelimb touchdown, we measured hindlimb angular excursion and ankle position for 84 walking strides, across three different types of gaits (diagonal sequence, diagonal couplets (DSDC); lateral sequence lateral couplets (LSLC); and lateral sequence diagonal couplets (LSDC)) [27].
  • The purpose of this study was to compare selected physiological responses of nonweight-bearing (NWB) and touchdown (TD) ambulation using axillary crutches [28].
  • The degree of osteogenetic response attributable to the electrical stimulation is undetermined because other factors, including cast immobilization, time and minimal touchdown (25 pounds) weight-bearing in the cast during the period of observation, may also have had some influence on the healing response [29].
  • These data demonstrate that modified cycling regimens that incorporate elevated annealing temperatures (with or without an initial touchdown routine) may markedly improve the performance of rep-PCR fingerprinting as a bacterial typing tool [30].


  1. Rapid diagnosis of respiratory Chlamydia pneumoniae infection by nested touchdown polymerase chain reaction compared with culture and antigen detection by EIA. Boman, J., Allard, A., Persson, K., Lundborg, M., Juto, P., Wadell, G. J. Infect. Dis. (1997) [Pubmed]
  2. Chlamydia pneumoniae and chronic bronchitis: association with severity and bacterial clearance following treatment. Blasi, F., Damato, S., Cosentini, R., Tarsia, P., Raccanelli, R., Centanni, S., Allegra, L. Thorax (2002) [Pubmed]
  3. Locomotor kinetics and kinematics on inclines and declines in the gray short-tailed opossum Monodelphis domestica. Lammers, A.R., Earls, K.D., Biknevicius, A.R. J. Exp. Biol. (2006) [Pubmed]
  4. Serial kinematic analysis of the unstable knee after transection of the anterior cruciate ligament: temporal and angular changes in a canine model of osteoarthritis. Vilensky, J.A., O'Connor, B.L., Brandt, K.D., Dunn, E.A., Rogers, P.I., DeLong, C.A. J. Orthop. Res. (1994) [Pubmed]
  5. Gating of sensation and evoked potentials following foot stimulation during human gait. Duysens, J., Tax, A.A., Nawijn, S., Berger, W., Prokop, T., Altenmüller, E. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale. (1995) [Pubmed]
  6. 'Touchdown' PCR to circumvent spurious priming during gene amplification. Don, R.H., Cox, P.T., Wainwright, B.J., Baker, K., Mattick, J.S. Nucleic Acids Res. (1991) [Pubmed]
  7. Vitamin D(3) metabolism in human glioblastoma multiforme: functionality of CYP27B1 splice variants, metabolism of calcidiol, and effect of calcitriol. Diesel, B., Radermacher, J., Bureik, M., Bernhardt, R., Seifert, M., Reichrath, J., Fischer, U., Meese, E. Clin. Cancer Res. (2005) [Pubmed]
  8. Molecular identification and immunolocalization of the water channel protein aquaporin 1 in CBCECs. Li, J., Kuang, K., Nielsen, S., Fischbarg, J. Invest. Ophthalmol. Vis. Sci. (1999) [Pubmed]
  9. Lateral bending of the lumbar spine during quadrupedalism in strepsirhines. Shapiro, L.J., Demes, B., Cooper, J. J. Hum. Evol. (2001) [Pubmed]
  10. Touchdown enzyme time release-PCR for detection and identification of Chlamydia trachomatis, C. pneumoniae, and C. psittaci using the 16S and 16S-23S spacer rRNA genes. Madico, G., Quinn, T.C., Boman, J., Gaydos, C.A. J. Clin. Microbiol. (2000) [Pubmed]
  11. Utility of random amplified polymorphic DNA PCR and TaqMan automated detection in molecular identification of Aspergillus fumigatus. Brandt, M.E., Padhye, A.A., Mayer, L.W., Holloway, B.P. J. Clin. Microbiol. (1998) [Pubmed]
  12. Etiology of iliotibial band friction syndrome in distance runners. Messier, S.P., Edwards, D.G., Martin, D.F., Lowery, R.B., Cannon, D.W., James, M.K., Curl, W.W., Read, H.M., Hunter, D.M. Medicine and science in sports and exercise. (1995) [Pubmed]
  13. Evaluation of lower extremity overuse injury potential in runners. Hreljac, A., Marshall, R.N., Hume, P.A. Medicine and science in sports and exercise. (2000) [Pubmed]
  14. Touchdown thermocycling program enables a robust single nucleotide polymorphism typing method based on allele-specific real-time polymerase chain reaction. Wu, W.M., Tsai, H.J., Pang, J.H., Wang, H.S., Hong, H.S., Lee, Y.S. Anal. Biochem. (2005) [Pubmed]
  15. The influence of foot positioning on ankle sprains. Wright, I.C., Neptune, R.R., van den Bogert, A.J., Nigg, B.M. Journal of biomechanics. (2000) [Pubmed]
  16. Neuromuscular control of the human leg extensor muscles in jump exercises under various stretch-load conditions. Gollhofer, A., Kyröläinen, H. International journal of sports medicine. (1991) [Pubmed]
  17. The effect of falling height on muscle activity and foot motion during landings. Arampatzis, A., Morey-Klapsing, G., Brüggemann, G.P. Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology. (2003) [Pubmed]
  18. Interaction between pre-landing activities and stiffness regulation of the knee joint musculoskeletal system in the drop jump: implications to performance. Horita, T., Komi, P.V., Nicol, C., Kyröläinen, H. European journal of applied physiology. (2002) [Pubmed]
  19. Feasibility of a cost-effective approach to evaluate short tandem repeat markers suitable for chimerism follow-up. Fundia, A.F., De Brasi, C., Larripa, I. Mol. Diagn. (2004) [Pubmed]
  20. Amplification and characterization of cysteine proteinase genes from nematodes. Harrop, S.A., Prociv, P., Brindley, P.J. Trop. Med. Parasitol. (1995) [Pubmed]
  21. Fluorescent multiplex PCR--fast method for autosomal dominant spinocerebellar ataxias screening. Bauer, P.O., Kotliarova, S.E., Matoska, V., Musova, Z., Hedvicakova, P., Boday, A., Tomek, A., Nukina, N., Goetz, P. Genetika (2005) [Pubmed]
  22. Rapid touchdown PCR assay for the molecular diagnosis of spinocerebellar ataxia type 2. Condorelli, D.F., Trovato-Salinaro, A., Spinella, F., Valvo, S., Saponara, R., Giuffrida, S. Int. J. Clin. Lab. Res. (1998) [Pubmed]
  23. Pneumocystis jiroveci isolates with dihydropteroate synthase mutations in patients with chronic bronchitis. Calderón, E., de la Horra, C., Medrano, F.J., López-Suárez, A., Montes-Cano, M.A., Respaldiza, N., Elvira-González, J., Martín-Juan, J., Bascuñana, A., Varela, J.M. Eur. J. Clin. Microbiol. Infect. Dis. (2004) [Pubmed]
  24. Improved prenatal detection of a fetal point mutation for achondroplasia by the use of size-fractionated circulatory DNA in maternal plasma--case report. Li, Y., Holzgreve, W., Page-Christiaens, G.C., Gille, J.J., Hahn, S. Prenat. Diagn. (2004) [Pubmed]
  25. Chlamydia pneumoniae in asymptomatic carotid atherosclerosis. Sessa, R., Di Pietro, M., Schiavoni, G., Galdiero, M., Cipriani, P., Romano, S., Zagaglia, C., Santino, I., Faccilongo, S., Del Piano, M. International journal of immunopathology and pharmacology. (2006) [Pubmed]
  26. Multi-detector row CT versus coronary angiography: preoperative evaluation before totally endoscopic coronary artery bypass grafting. Herzog, C., Dogan, S., Diebold, T., Khan, M.F., Ackermann, H., Schaller, S., Flohr, T.G., Wimmer-Greinecker, G., Moritz, A., Vogl, T.J. Radiology. (2003) [Pubmed]
  27. Lateral sequence walking in infant Papio cynocephalus: implications for the evolution of diagonal sequence walking in primates. Shapiro, L.J., Raichlen, D.A. Am. J. Phys. Anthropol. (2005) [Pubmed]
  28. Cardiovascular responses during nonweight-bearing and touchdown ambulation. Kathrins, B.P., O'Sullivan, S.D. Physical therapy. (1984) [Pubmed]
  29. Percutaneous electrical stimulation for clinical tibial fracture repair. Romano, R.L., Burgess, E.M., Rubenstein, C.P. Clin. Orthop. Relat. Res. (1976) [Pubmed]
  30. Improved repetitive-element PCR fingerprinting of Salmonella enterica with the use of extremely elevated annealing temperatures. Johnson, J.R., Clabots, C. Clin. Diagn. Lab. Immunol. (2000) [Pubmed]
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