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Gene Review

SETD1A  -  SET domain containing 1A

Homo sapiens

Synonyms: Histone-lysine N-methyltransferase SETD1A, KIAA0339, KMT2F, Lysine N-methyltransferase 2F, SET domain-containing protein 1A, ...
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Disease relevance of SETD1A

  • These results indicate that H3K4me3 mediated by Set1 is required for optimal gene expression and replication of HSV-1 during lytic infection and suggest that this pathway could be a potential point of pharmacological intervention during HSV-1 infection [1].
  • Trimethylation of histone H3 lysine 4 by Set1 in the lytic infection of human herpes simplex virus 1 [1].
  • Shigella enterotoxin 1 (ShET1) is a novel, iron-dependent, toxin encoded by chromosomal genes (set1) [2].
  • Cropp et al. postulated that two sets of mutational events occurred simultaneously in a higher degree of breast tumors than expected based on chance: Set 1 consisted of deletions on 11p, 17p, 18q, and int-2 and myc amplifications; set 2 consisted of 17q, 1p, and 3p deletions [3].

Psychiatry related information on SETD1A

  • A Multivariate Analysis of Covariance revealed a negative influence of depression on the two RMT measures (Acquisition-Recall: AR; Delayed Memory: DM) and on the three SMS measures (Set1: self-comparison; Set2: memory complaints; Set3: peer comparison), and of age on AR and DM, and Set1 and Set2 [4].

High impact information on SETD1A

  • Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1 [5].
  • Methylation at H3 K4 by Set1 is required for set2 to suppress yFACT defects [6].
  • Using small interference RNA, we found that the reduction of Set1, but not Set7/9, reduces the transcription and replication of HSV-1 and specifically decreases H3K4me3 on the virus genome [1].
  • A reserve panel of alternate VH consensus primers directed at framework II or III regions was used only when Set 1 showed no evidence of B-cell monoclonality.(ABSTRACT TRUNCATED AT 250 WORDS)[7]
  • Set 1 included admission data (age, sex, comorbidity, injury mechanism, Glasgow Coma Scale, Injury Severity Score, and systolic blood pressure determined in the emergency department) plus the amount of blood transfused within the first 12 hours [8].

Biological context of SETD1A

  • Areas under the ROC curves (AUC) for diagnosis using different monitors were compared for each image set and the following results obtained: Set 1: Monochrome AUC = 0.873 +/- 0.026; Colour AUC = 0.831 +/- 0.032; Set 2: Monochrome AUC = 0.945 +/- 0.014; Colour AUC = 0.931 +/- 0.019; Differences in AUC were attributed to the different monitors [9].

Anatomical context of SETD1A

  • RESULTS: After Day 8 the lesions in Set 1 extended into dentin and so could not be evaluated [10].
  • The urological anomalies were: Set 1; both twins had one lateral crossed fused renal ectopia with uncrossed ureters draining into a single bladder with one urethra [11].

Associations of SETD1A with chemical compounds

  • Histone H3 lysine 4 methylation is mediated by Set1 and promotes maintenance of active chromatin states in fission yeast [12].
  • Set 1 grouped compounds with m/z 495, and set 2 included compounds with m/z 479, in both cases for the protonated molecular mass [13].
  • Axial SET1-weighted and TSET2-weighted, sagittal and coronal T2-weighted sequences using Fat-suppression were acquired [14].

Analytical, diagnostic and therapeutic context of SETD1A

  • Cochlear implant listeners achieved higher levels of performance with Talker Set 1, while performance was significantly reduced for Talker Set 2 [15].
  • The reliability and validity of the trait form of the Depression Adjective Check List (DACL) for Sets 1 and 2 were determined with adolescents in Grades 7 to 9 (Set 1) and Grades 8 to 12 (Set 2) [16].
  • After shaving the back hair, SDF was dosed to two sets of three male dark-agouti pigmented rats (5 weeks old) per each group at 25 mg/kg once a day for 5 successive days with intraperitoneal (i.p.) (set1) and oral administration (set2) [17].


  1. Trimethylation of histone H3 lysine 4 by Set1 in the lytic infection of human herpes simplex virus 1. Huang, J., Kent, J.R., Placek, B., Whelan, K.A., Hollow, C.M., Zeng, P.Y., Fraser, N.W., Berger, S.L. J. Virol. (2006) [Pubmed]
  2. Prevalence of Shigella enterotoxin 1 among Shigella clinical isolates of diverse serotypes. Noriega, F.R., Liao, F.M., Formal, S.B., Fasano, A., Levine, M.M. J. Infect. Dis. (1995) [Pubmed]
  3. Suppressor genes in breast cancer: an overview. Steeg, P.S. Cancer Treat. Res. (1992) [Pubmed]
  4. The influence of depression on memory and metamemory in the elderly. Cipolli, C., Neri, M., De Vreese, L.P., Pinelli, M., Rubichi, S., Lalla, M. Archives of gerontology and geriatrics. (1996) [Pubmed]
  5. Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1. Wysocka, J., Myers, M.P., Laherty, C.D., Eisenman, R.N., Herr, W. Genes Dev. (2003) [Pubmed]
  6. Opposing roles for Set2 and yFACT in regulating TBP binding at promoters. Biswas, D., Dutta-Biswas, R., Mitra, D., Shibata, Y., Strahl, B.D., Formosa, T., Stillman, D.J. EMBO J. (2006) [Pubmed]
  7. Optimal primer selection for clonality assessment by polymerase chain reaction analysis: I. Low grade B-cell lymphoproliferative disorders of nonfollicular center cell type. Segal, G.H., Jorgensen, T., Masih, A.S., Braylan, R.C. Hum. Pathol. (1994) [Pubmed]
  8. Blood transfusion. An independent risk factor for postinjury multiple organ failure. Moore, F.A., Moore, E.E., Sauaia, A. Archives of surgery (Chicago, Ill. : 1960) (1997) [Pubmed]
  9. Comparison of computer display monitors for computed radiography diagnostic application in a radiology PACS. Sim, L., Manthey, K., Esdaile, P., Benson, M. Australasian physical & engineering sciences in medicine / supported by the Australasian College of Physical Scientists in Medicine and the Australasian Association of Physical Sciences in Medicine. (2004) [Pubmed]
  10. In vitro model for evaluating the effect of child formula toothpastes on artificial caries in primary dentition enamel. Thaveesangpanich, P., Itthagarun, A., King, N.M., Wefel, J.S., Tay, F.R. American journal of dentistry. (2005) [Pubmed]
  11. Urological problems in conjoined twins. Wilcox, D.T., Quinn, F.M., Spitz, L., Kiely, E.M., Ransley, P.G. British journal of urology. (1998) [Pubmed]
  12. Histone H3 lysine 4 methylation is mediated by Set1 and promotes maintenance of active chromatin states in fission yeast. Noma, K., Grewal, S.I. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  13. Thermal degradation products formed from carotenoids during a heat-induced degradation process of paprika oleoresins (Capsicum annuum L.). Pérez-Gálvez, A., Rios, J.J., Mínguez-Mosquera, M.I. J. Agric. Food Chem. (2005) [Pubmed]
  14. Magnetic resonance imaging using endoanal coil in anal canal tumors after radiochemotherapy or local excision. Indinnimeo, M., Cicchini, C., Stazi, A., Alessandrini, G., Ghini, C., Fanelli, F., Pavone, P. International surgery. (2000) [Pubmed]
  15. Voice gender identification by cochlear implant users: the role of spectral and temporal resolution. Fu, Q.J., Chinchilla, S., Nogaki, G., Galvin, J.J. The Journal of the Acoustical Society of America. (2005) [Pubmed]
  16. Measuring trait-depressive mood in adolescents with the depression adjective check lists. Lubin, B., McCollum, K.L., Van Whitlock, R., Thummel, H., Powers, M., Davis, V. Adolescence. (1994) [Pubmed]
  17. Hair analysis for pharmaceutical drugs. II. Effective extraction and determination of sildenafil (Viagra) and its N-desmethyl metabolite in rat and human hair by GC-MS. Saisho, K., Scott, K.S., Morimoto, S., Nakahara, Y. Biol. Pharm. Bull. (2001) [Pubmed]
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