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Gene Review

KIAA0101  -  KIAA0101

Homo sapiens

Synonyms: HCV NS5A-transactivated protein 9, Hepatitis C virus NS5A-transactivated protein 9, L5, NS5ATP9, OEATC, ...
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Disease relevance of KIAA0101

  • Among dozens of trans-activated genes in pancreatic cancer cells, this study focused on KIAA0101 whose overexpression in pancreatic cancer cells was validated by immunohistochemical analysis [1].
  • In our recombinants, COPV L1 is incorporated into adenovirus late region 5 (Ad L5) and is expressed as a member of the adenoviral major late transcriptional unit (MLTU) [2].
  • Noninfectious virions lacking L5 could bind to cells, but the cores did not enter the cytoplasm [3].
  • Thus, L5 is the fourth component of the poxvirus cell entry/fusion apparatus that is required for entry of both the intracellular and extracellular infectious forms of vaccinia virus [3].
  • Phage L5 was characterized in more detail because of its strong hybridization to the cDNA probe and its unique restriction map compared to the gene coding for human prothrombin [4].

High impact information on KIAA0101

  • This implies that precisely the same transcription start site is utilized for early L1 mRNA synthesis as is used during the late stage for L1-L5 late mRNA synthesis [5].
  • The major late promoter of adeovirus-2 is located at coordinate 16.45 and initiates synthesis of nuclear precursors that are processed into mRNAs which fall into five 3- co-terminal families, L1-L5 [5].
  • In addition to the previously characterized defect in late mRNA translation, mutant infected cells also show an aberrant selection of RNA splice sites and a substantially reduced L2, L3, and L5 mRNA accumulation [6].
  • Oncogenic role of KIAA0101 interacting with proliferating cell nuclear antigen in pancreatic cancer [1].
  • We also showed that the expression of KIAA0101 was regulated tightly by the p53-p21 pathway [1].

Biological context of KIAA0101

  • Concordantly, exogenous overexpression of KIAA0101 enhanced cancer cell growth, and NIH3T3 derivative cells expressing KIAA0101 revealed in vivo tumor formation, implying its growth-promoting and oncogenic property [1].
  • To investigate for the biological significance of KIAA0101 overexpression in cancer cells, we knocked down KIAA0101 by small interfering RNA (siRNA) in pancreatic cancer cells and found that the reduced expression by siRNA caused drastic attenuation of their proliferation as well as significant decrease in DNA replication rate [1].
  • FACS was used to analyze the cell cycle pattern in KIAA0101 expression positive (+) and negative (-) cell populations isolated by the pMACSKKII system after KIAA0101 cDNA transfection [7].
  • To evaluate the effects of OEATC-1 on tumor cell growth, gene silencing was caused by transfecting the plasmid-generating siRNA effect to KTA2 cells [8].
  • L5 is known to bind specifically to 5 S rRNA and is involved in nucleocytoplasmic transport of this rRNA [9].

Anatomical context of KIAA0101

  • KIAA0101 was predominantly localized in mitochondria and partially in nuclei [7].
  • From the extended list, they focused on hypothetical and anonymous genes and investigated a novel gene, named the overexpressed in anaplastic thyroid carcinoma-1 (OEATC-1) gene [8].
  • RESULTS: OEATC-1 was overexpressed significantly in ACLs and in other types of carcinoma cell lines with various expression levels [8].
  • The spinal monosynaptic reflex amplitude (MSR) was recorded from the L5 ventral root following stimulation of the ipsilateral L5 dorsal root [10].
  • Using this new technique, the authors removed part of the hypertrophied superior facet, thickened ligamentum flavum, and protruded disc compressing the exiting (L-5) nerve root [11].

Associations of KIAA0101 with chemical compounds

  • The putative protein encoded by the gene in L5 contains four kringle domains followed by a serine protease-like domain [4].
  • Sequence analysis of cyanogen bromide-digested phosphopeptides and analysis of L5 deletion mutants indicates that the main phosphorylated residues are located within two fragments corresponding of residues 142-200 and residues 272-297 of the human L5 [12].

Physical interactions of KIAA0101

  • The PCNA-associated factor KIAA0101/p15(PAF) binds the potential tumor suppressor product p33ING1b [13].

Regulatory relationships of KIAA0101


Analytical, diagnostic and therapeutic context of KIAA0101


  1. Oncogenic role of KIAA0101 interacting with proliferating cell nuclear antigen in pancreatic cancer. Hosokawa, M., Takehara, A., Matsuda, K., Eguchi, H., Ohigashi, H., Ishikawa, O., Shinomura, Y., Imai, K., Nakamura, Y., Nakagawa, H. Cancer Res. (2007) [Pubmed]
  2. Viable adenovirus vaccine prototypes: high-level production of a papillomavirus capsid antigen from the major late transcriptional unit. Berg, M., Difatta, J., Hoiczyk, E., Schlegel, R., Ketner, G. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  3. The product of the vaccinia virus L5R gene is a fourth membrane protein encoded by all poxviruses that is required for cell entry and cell-cell fusion. Townsley, A.C., Senkevich, T.G., Moss, B. J. Virol. (2005) [Pubmed]
  4. Characterization of the DNF15S2 locus on human chromosome 3: identification of a gene coding for four kringle domains with homology to hepatocyte growth factor. Han, S., Stuart, L.A., Degen, S.J. Biochemistry (1991) [Pubmed]
  5. Transcripts from the adenovirus-2 major late promoter yield a single early family of 3' coterminal mRNAs and five late families. Shaw, A.R., Ziff, E.B. Cell (1980) [Pubmed]
  6. Defective RNA splicing in the absence of adenovirus-associated RNAI. Svensson, C., Akusjärvi, G. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  7. KIAA0101 (OEACT-1), an expressionally down-regulated and growth-inhibitory gene in human hepatocellular carcinoma. Guo, M., Li, J., Wan, D., Gu, J. BMC Cancer (2006) [Pubmed]
  8. Overexpressed in anaplastic thyroid carcinoma-1 (OEATC-1) as a novel gene responsible for anaplastic thyroid carcinoma. Mizutani, K., Onda, M., Asaka, S., Akaishi, J., Miyamoto, S., Yoshida, A., Nagahama, M., Ito, K., Emi, M. Cancer (2005) [Pubmed]
  9. Human ribosomal protein L5 contains defined nuclear localization and export signals. Rosorius, O., Fries, B., Stauber, R.H., Hirschmann, N., Bevec, D., Hauber, J. J. Biol. Chem. (2000) [Pubmed]
  10. Spinal cord injury-specific depression of monosynaptic spinal reflex transmission by l-5-hydroxytryptophan results from loss of the 5-HT uptake system and not 5-HT receptor supersensitivity. Honda, M., Tanabe, M., Ono, H. Exp. Neurol. (2006) [Pubmed]
  11. Posterolateral percutaneous endoscopic lumbar foraminotomy for L5-S1 foraminal or lateral exit zone stenosis. Technical note. Ahn, Y., Lee, S.H., Park, W.M., Lee, H.Y. J. Neurosurg. (2003) [Pubmed]
  12. Phosphorylation of ribosomal protein L5 by protein kinase CKII decreases its 5S rRNA binding activity. Park, J.W., Bae, Y.S. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  13. The PCNA-associated factor KIAA0101/p15(PAF) binds the potential tumor suppressor product p33ING1b. Simpson, F., Lammerts van Bueren, K., Butterfield, N., Bennetts, J.S., Bowles, J., Adolphe, C., Simms, L.A., Young, J., Walsh, M.D., Leggett, B., Fowles, L.F., Wicking, C. Exp. Cell Res. (2006) [Pubmed]
  14. A collagen-based sealant to prevent in vivo reformation of epidural scar adhesions in an adult rat laminectomy model. Liu, S., Boutrand, J.P., Bittoun, J., Tadie, M. J. Neurosurg. (2002) [Pubmed]
  15. Total sacrectomy and Galveston L-rod reconstruction for malignant neoplasms. Technical note. Gokaslan, Z.L., Romsdahl, M.M., Kroll, S.S., Walsh, G.L., Gillis, T.A., Wildrick, D.M., Leavens, M.E. J. Neurosurg. (1997) [Pubmed]
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