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Chemical Compound Review

Metanil Yellow VS     sodium3-(4- phenylazanylphenyl) diazenylben...

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Disease relevance of Shikiso Metanil Yellow


High impact information on Shikiso Metanil Yellow


Chemical compound and disease context of Shikiso Metanil Yellow

  • Parenteral administration of metanil yellow (80 mg/kg body weight) to another set of four animals for 3 days resulted in higher induction of ethoxyresorufin-O-deethylase (228%) as compared to other monooxygenases (64-92%), while GST and QR were also found to be induced (59-95%) [10].

Biological context of Shikiso Metanil Yellow


Anatomical context of Shikiso Metanil Yellow


Associations of Shikiso Metanil Yellow with other chemical compounds

  • The synthesis of seven monoazo benzotriazole dyes for use in surface enhanced resonance Raman scattering, SERRS, is reported [7].
  • The pro-oxidant free or FeSO4/ADP (1 mM/5 mM) or ascorbate (1 mM) dependent non-enzymatic lipid peroxidation in nuclear, mitochondrial and microsomal fractions was found to be enhanced by Metanil yellow to a greater extent as compared to Orange II, while the blend showed a synergistic or additive response [9].
  • Oral administration of Metanil yellow (430 mg kg-1 body wt.) for 7 days caused significant depletion of hepatic and intestinal glutathione levels (33-52%) with a concomitant increase in lipid peroxidation (49-121%) [19].
  • 3. All five tryptophan residues of the protein react with the diazonium ion below pH 7 forming a monoazo derivative with an absorption maximum at 370 nm, above pH 7 only four residues couple with diazo-1-H-tetrazole [20].
  • Four new methods using titrimetry and spectrophotometry are described for the determination of ranitidine hydrochloride (RNH) with potassium bromate as the oxidimetric reagent and acid dyes, methyl orange, indigo carmine and metanil yellow [21].

Gene context of Shikiso Metanil Yellow

  • Concentrations of metanil yellow and orange II as low as 22 nM and 12 nM, respectively, were sufficient to induce mutation rates which were equal to twice the spontaneous mutation rate at the HPRT locus in AHH-1 cells [22].
  • It can be concluded that Metanil yellow acts as an inducer of a specific form of microsomal P-450 and cytosolic GST and QR, which may involve a cytosolic Ah receptor [19].
  • Haematological changes induced by feeding a common food colour, metanil yellow, in albino mice [1].
  • Therefore, the decolourisation of two azo textile dyes, a monoazo dye (Acid Orange 7, AO7) and a diazo dye (Direct Red 254, DR254), was investigated in a methanogenic laboratory-scale Upflow Anaerobic Sludge Blanket (UASB), fed with acetate as primary carbon source [23].
  • Metanil yellow & gastric mucin [24].

Analytical, diagnostic and therapeutic context of Shikiso Metanil Yellow


  1. Haematological changes induced by feeding a common food colour, metanil yellow, in albino mice. Prasad, O.M., Rastogi, P.B. Toxicol. Lett. (1983) [Pubmed]
  2. Toxicity studies on metanil yellow in rats. Khanna, S.K., Srivastava, L.P., Singh, G.B. Environmental research. (1978) [Pubmed]
  3. A case of allergic contact dermatitis due to metanil yellow. Hausen, B.M. Contact Derm. (1994) [Pubmed]
  4. Optimal decolorization and kinetic modeling of synthetic dyes by Pseudomonas strains. Yu, J., Wang, X., Yue, P.L. Water Res. (2001) [Pubmed]
  5. Metabolic activation and inactivation of metanil yellow and orange II in the Salmonella typhimurium his-reversion assay. Rastogi, P.B., Levin, R.E. J. Food Prot. (1996) [Pubmed]
  6. Mutagenicity of some lipsticks and their dyes. Green, M.R., Pastewka, J.V. J. Natl. Cancer Inst. (1980) [Pubmed]
  7. SERRS dyes. Part I. Synthesis of benzotriazole monoazo dyes as model analytes for surface enhanced resonance Raman scattering. McAnally, G., McLaughlin, C., Brown, R., Robson, D.C., Faulds, K., Tackley, D.R., Smith, W.E., Graham, D. The Analyst. (2002) [Pubmed]
  8. Steric and electrostatic effects in dye-cellulose interactions by the MTD and CoMFA approaches. Timofeir, S., Kurunczi, L., Schmidt, W., Simon, Z. SAR and QSAR in environmental research. (2002) [Pubmed]
  9. Lipid peroxidation of ultrastructural components of rat liver induced by metanil yellow and orange II: comparison with blend. Ramachandani, S., Das, M., Khanna, S.K. Toxicology and industrial health. (1992) [Pubmed]
  10. Metanil yellow: a bifunctional inducer of hepatic phase I and phase II xenobiotic-metabolizing enzymes. Das, M., Ramchandani, S., Upreti, R.K., Khanna, S.K. Food Chem. Toxicol. (1997) [Pubmed]
  11. In vitro studies on the biotransformation of metanil yellow. Srivastava, L.P., Khanna, S.K., Singh, G.B., Murti, C.R. Environmental research. (1982) [Pubmed]
  12. Sister chromatid exchange induced by metanil yellow and nitrite singly and in combination in vivo on mice. Giri, A.K., Talukder, G., Sharma, A. Cancer Lett. (1986) [Pubmed]
  13. In vivo cytogenetic studies on mice exposed to Orange G, a food colourant. Giri, A.K., Mukherjee, A., Talukder, G., Sharma, A. Toxicol. Lett. (1988) [Pubmed]
  14. Effects of metanil yellow on human leucocyte chromosomes in vitro. Vaidya, V.G., Godbole, N.N. Indian J. Exp. Biol. (1978) [Pubmed]
  15. Tumor promotion by metanil yellow and malachite green during rat hepatocarcinogenesis is associated with dysregulated expression of cell cycle regulatory proteins. Gupta, S., Sundarrajan, M., Rao, K.V. Teratog., Carcinog. Mutagen. (2003) [Pubmed]
  16. Effects of chronic consumption of metanil yellow by developing and adult rats on brain regional levels of noradrenaline, dopamine and serotonin, on acetylcholine esterase activity and on operant conditioning. Nagaraja, T.N., Desiraju, T. Food Chem. Toxicol. (1993) [Pubmed]
  17. Stimulation of DNA synthesis in primary rat hepatocyte cultures by metanil yellow: a new liver tumour promoter. Rao, K.V. Indian J. Med. Res. (1995) [Pubmed]
  18. Differential dichrome staining of tissue culture monolayers: alternate dyes and possible mechanism. Everett, M.M., Miller, W.A. Stain technology. (1978) [Pubmed]
  19. Effect of oral and parenteral administration of metanil yellow on some hepatic and intestinal biochemical parameters. Ramchandani, S., Das, M., Joshi, A., Khanna, S.K. Journal of applied toxicology : JAT. (1997) [Pubmed]
  20. On the reaction of papain and succinylpapin with diazo-1-H-tetrazole. Löffler, H.G., Schneider, F.R. Biochim. Biophys. Acta (1975) [Pubmed]
  21. Determination of ranitidine hydrochloride in pharmaceutical preparations by titrimetry and visible spectrophotometry using bromate and acid dyes. Basavaiah, K., Nagegowda, P. Farmaco (2004) [Pubmed]
  22. Long-term low-dose mutation studies in human cells: metanil yellow and orange II. Rastogi, P.B., Thilly, W.G., Shirnamé-Moré, L. Mutat. Res. (1991) [Pubmed]
  23. Monoazo and diazo dye decolourisation studies in a methanogenic UASB reactor. Brás, R., Gomes, A., Ferra, M.I., Pinheiro, H.M., Gonçalves, I.C. J. Biotechnol. (2005) [Pubmed]
  24. Metanil yellow & gastric mucin. Raza, H., Khanna, S.K., Singh, G.B. Indian J. Exp. Biol. (1978) [Pubmed]
  25. Acquired toxic methaemoglobinaemia. Sachdeva, S.M., Mani, K.V., Adaval, S.K., Jalpota, Y.P., Rasela, K.C., Chadha, D.S. The Journal of the Association of Physicians of India. (1992) [Pubmed]
  26. Asthma, rhinitis, and dermatitis in workers exposed to reactive dyes. Nilsson, R., Nordlinder, R., Wass, U., Meding, B., Belin, L. British journal of industrial medicine. (1993) [Pubmed]
  27. Effect of protein malnutrition on sex organs of metanil yellow exposed male rats. Singh, R.L. Biomed. Environ. Sci. (1998) [Pubmed]
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