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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Hiccup


Psychiatry related information on Hiccup


High impact information on Hiccup


Chemical compound and disease context of Hiccup


Biological context of Hiccup

  • Mechanical stimulation of the epipharynx evoked a fixed motor pattern of hiccup: DIA showed spasmodic discharge, and Ppl exhibited spiky negative pressure swing; phasic (inspiratory) discharge of PCA was inhibited, and glottic adduction was revealed by direct observation; and ABD remained suppressed during this response [17].
  • The steroid-responsive hiccup reflex arc: competitive binding to the corticosteroid-receptor [18]?

Gene context of Hiccup

  • We present a patient with long-standing symptomatic GER and intractable hiccups [19].
  • Fifteen male patients (mean [+/- SD] age, 68.2 +/- 11.6 years) who had recurring hiccup attacks for a mean duration of 100.8 +/- 134.1 months (range, 12 to 564 months) were treated for ICH with a combination of cisapride, omeprazole, and baclofen (COB) [20].
  • We conclude that cisplatin-related hiccups are predominant in males, dexamethasone-induced, and associated with protection against nausea/vomiting [21].
  • CONCLUSIONS: Brain MR is a useful investigation in patients with chronic hiccups when gastroesophageal lesions are either excluded or too mild to account for an intractable hiccup [22].
  • Intractable hiccup as the initial presenting feature of systemic lupus erythematosus [23].

Analytical, diagnostic and therapeutic context of Hiccup


  1. Use of baclofen for intractable hiccups in uremia. Krahn, A., Penner, S.B. Am. J. Med. (1994) [Pubmed]
  2. Aprepitant: a review of its use in the prevention of chemotherapy-induced nausea and vomiting. Dando, T.M., Perry, C.M. Drugs (2004) [Pubmed]
  3. Metoclopramide: a review of its pharmacological properties and clinical use. Pinder, R.M., Brogden, R.N., Sawyer, P.R., Speight, T.M., Avery, G.S. Drugs (1976) [Pubmed]
  4. Desflurane or sevoflurane for gynaecological day-case anaesthesia with spontaneous respiration? Mahmoud, N.A., Rose, D.J., Laurence, A.S. Anaesthesia. (2001) [Pubmed]
  5. Short report: severe hiccups secondary to doxycycline-induced esophagitis during treatment of malaria. Tzianetas, I., Habal, F., Keystone, J.S. Am. J. Trop. Med. Hyg. (1996) [Pubmed]
  6. Sleep hiccup. Askenasy, J.J. Sleep. (1988) [Pubmed]
  7. Nefopam for severe hiccups. Bilotta, F., Rosa, G. N. Engl. J. Med. (2000) [Pubmed]
  8. Pseudolithiasis and intractable hiccups in a boy receiving ceftriaxone. Bonioli, E., Bellini, C., Tomà, P. N. Engl. J. Med. (1994) [Pubmed]
  9. Lidocaine for severe hiccups. Dunst, M.N., Margolin, K., Horak, D. N. Engl. J. Med. (1993) [Pubmed]
  10. Baclofen for intractable hiccups. Burke, A.M., White, A.B., Brill, N. N. Engl. J. Med. (1988) [Pubmed]
  11. Persistent hiccup cured by amantadine. Askenasy, J.J., Boiangiu, M., Davidovitch, S. N. Engl. J. Med. (1988) [Pubmed]
  12. Nifedipine for intractable hiccups. Mukhopadhyay, P., Osman, M.R., Wajima, T., Wallace, T.I. N. Engl. J. Med. (1986) [Pubmed]
  13. Hiccough relief with cisapride. Duffy, M.C., Edmond, H., Campbell, K., Fulton, J.D. Lancet (1992) [Pubmed]
  14. Intractable hiccups associated with high-dose intravenous methylprednisolone therapy. Baethge, B.A., Lidsky, M.D. Ann. Intern. Med. (1986) [Pubmed]
  15. Trimethoprim-sulfamethoxazole, hiccups, and esophageal ulcers. Seibert, D., Al-Kawas, F. Ann. Intern. Med. (1986) [Pubmed]
  16. Hiccup with dexamethasone therapy. LeWitt, P.A., Barton, N.W., Posner, J.B. Ann. Neurol. (1982) [Pubmed]
  17. Hiccuplike response elicited by mechanical stimulation of dorsal epipharynx of cats. Oshima, T., Sakamoto, M., Arita, H. J. Appl. Physiol. (1994) [Pubmed]
  18. The steroid-responsive hiccup reflex arc: competitive binding to the corticosteroid-receptor? Dickerman, R.D., Overby, C., Eisenberg, M., Hollis, P., Levine, M. Neuro Endocrinol. Lett. (2003) [Pubmed]
  19. Hiccups: esophageal manometric features and relationship to gastroesophageal reflux. Marshall, J.B., Landreneau, R.J., Beyer, K.L. Am. J. Gastroenterol. (1990) [Pubmed]
  20. Idiopathic chronic hiccup: combination therapy with cisapride, omeprazole, and baclofen. Petroianu, G., Hein, G., Petroianu, A., Bergler, W., Rüfer, R. Clinical therapeutics. (1997) [Pubmed]
  21. Cisplatin-related hiccups: male predominance, induction by dexamethasone, and protection against nausea and vomiting. Liaw, C.C., Wang, C.H., Chang, H.K., Wang, H.M., Huang, J.S., Lin, Y.C., Chen, J.S. Journal of pain and symptom management. (2005) [Pubmed]
  22. Intractable hiccups: the role of cerebral MR in cases without systemic cause. Marsot-Dupuch, K., Bousson, V., Cabane, J., Tubiana, J.M. AJNR. American journal of neuroradiology. (1995) [Pubmed]
  23. Intractable hiccup as the initial presenting feature of systemic lupus erythematosus. Delèvaux, I., André, M., Marroun, I., Lamaison, D., Piette, J.C., Aumaître, O. Lupus (2005) [Pubmed]
  24. Treatment of intractable hiccup with baclofen: results of a double-blind randomized, controlled, cross-over study. Ramírez, F.C., Graham, D.Y. Am. J. Gastroenterol. (1992) [Pubmed]
  25. Atropine for the treatment of hiccup after laryngeal mask insertion. Kanaya, N., Nakayama, M., Kanaya, J., Namiki, A. Anesth. Analg. (2001) [Pubmed]
  26. Recurrent persistent hiccups after epidural steroid injection and analgesia with bupivacaine. McAllister, R.K., McDavid, A.J., Meyer, T.A., Bittenbinder, T.M. Anesth. Analg. (2005) [Pubmed]
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