Disease relevance of Hiccup

• Use of baclofen for intractable hiccups in uremia [1].
• Other adverse events experienced by aprepitant recipients include anorexia, constipation, diarrhoea, nausea (after day 5 of the study) and hiccups [2].
• It may provide symptomatic relief in dyspepsia and possibly in vertigo, reflux oesophagitis and hiccups, but further controlled trials are needed to confirm the efficacy of metoclopramide in these proposed areas of use [3].
• There were five untoward airway events (coughing, hiccoughs) in the desflurane group and three in the sevoflurane group, including one laryngospasm [4].
• A 51-year-old man who was treated with quinine and doxycycline for Plasmodium falciparum malaria acquired in West Africa developed hiccups soon after his first dose of antimalarial therapy [5].

Psychiatry related information on Hiccup

• Hiccup (Hc) penetrates all sleep stages; in REM sleep, it becomes randomized [6].

High impact information on Hiccup

• Nefopam for severe hiccups [7].
• Pseudolithiasis and intractable hiccups in a boy receiving ceftriaxone [8].
• Lidocaine for severe hiccups [9].
• Baclofen for intractable hiccups [10].
• Persistent hiccup cured by amantadine [11].

Chemical compound and disease context of Hiccup

• Nifedipine for intractable hiccups [12].
• Hiccough relief with cisapride [13].
• Intractable hiccups associated with high-dose intravenous methylprednisolone therapy [14].
• Trimethoprim-sulfamethoxazole, hiccups, and esophageal ulcers [15].
• Hiccup with dexamethasone therapy [16].

Biological context of Hiccup

• Mechanical stimulation of the epipharynx evoked a fixed motor pattern of hiccup: DIA showed spasmodic discharge, and Ppl exhibited spiky negative pressure swing; phasic (inspiratory) discharge of PCA was inhibited, and glottic adduction was revealed by direct observation; and ABD remained suppressed during this response [17].
• The steroid-responsive hiccup reflex arc: competitive binding to the corticosteroid-receptor [18]?

Gene context of Hiccup

• We present a patient with long-standing symptomatic GER and intractable hiccups [19].
• Fifteen male patients (mean [+/- SD] age, 68.2 +/- 11.6 years) who had recurring hiccup attacks for a mean duration of 100.8 +/- 134.1 months (range, 12 to 564 months) were treated for ICH with a combination of cisapride, omeprazole, and baclofen (COB) [20].
• We conclude that cisplatin-related hiccups are predominant in males, dexamethasone-induced, and associated with protection against nausea/vomiting [21].
• CONCLUSIONS: Brain MR is a useful investigation in patients with chronic hiccups when gastroesophageal lesions are either excluded or too mild to account for an intractable hiccup [22].
• Intractable hiccup as the initial presenting feature of systemic lupus erythematosus [23].

Analytical, diagnostic and therapeutic context of Hiccup

• Four patients with intractable hiccup were treated in a double-blind, randomized, placebo, cross-over study with an analogue of gamma-aminobutyric acid, Baclofen [24].
• Esophageal manometry during hiccups showed absence of LES pressure and absence of peristaltic activity in the esophageal body in response to swallowing, factors which could aggravate GER [19].
• Atropine for the treatment of hiccup after laryngeal mask insertion [25].
• Recurrent persistent hiccups after epidural steroid injection and analgesia with bupivacaine [26].
• Substitution of saline for the dilute bupivacaine during epidural steroid injection did not result in hiccups; however, subsequent postoperative epidural analgesia with bupivacaine caused a recurrence of the hiccups [26].

References