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Chemical Compound Review

Ultiva     methyl1-(2- methoxycarbonylethyl)-4...

Synonyms: REMIFENTANIL, Remifentanyl, CHEMBL1005, SureCN36652, Ultiva (TN), ...
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Disease relevance of REMIFENTANIL


Psychiatry related information on REMIFENTANIL


High impact information on REMIFENTANIL


Chemical compound and disease context of REMIFENTANIL


Biological context of REMIFENTANIL


Anatomical context of REMIFENTANIL


Associations of REMIFENTANIL with other chemical compounds


Gene context of REMIFENTANIL

  • Remifentanil pharmacokinetics were best described by a two-compartment model with lean body mass as a significant covariate, where V1 = 0.129(lean body mass-50) + 3.79 l, V2 = 6.87 l, CL1 = 0.0389(lean body mass-50) + 2.34 l/min and CL2 = 1.14 l/min [34].
  • The effects of remifentanil on epileptiform discharges during intraoperative electrocorticography in patients undergoing epilepsy surgery [35].
  • This study was designed to evaluate the predictive performance of spectral edge frequency 95 (SEF95), BIS, and approximate entropy for the response to increasingly intense stimuli under different concentrations of both propofol and remifentanil in the therapeutic range [36].
  • The mean duration of mechanical ventilation and extubation time were significantly longer in the morphine group (18.1 +/- 3.4 h, 73 +/- 7 min) than in the remifentanil group (14.1 +/- 2.8 h, 17 +/- 6 min), respectively [37].
  • Dexmedetomidine pharmacodynamics: Part II: Crossover comparison of the analgesic effect of dexmedetomidine and remifentanil in healthy volunteers [38].

Analytical, diagnostic and therapeutic context of REMIFENTANIL


  1. Pharmacological FMRI: measuring opioid effects on the BOLD response to hypercapnia. Pattinson, K.T., Rogers, R., Mayhew, S.D., Tracey, I., Wise, R.G. J. Cereb. Blood Flow Metab. (2007) [Pubmed]
  2. The use of ultra-short-acting opioids in paediatric anaesthesia: the role of remifentanil. Davis, P.J., Cladis, F.P. Clinical pharmacokinetics. (2005) [Pubmed]
  3. The mu-opioid agonist remifentanil attenuates hyperalgesia evoked by blunt and punctuated stimuli with different potency: a pharmacological evaluation of the freeze lesion in humans. Lötsch, J., Angst, M.S. Pain (2003) [Pubmed]
  4. Pharmacokinetics of opioids in renal dysfunction. Davies, G., Kingswood, C., Street, M. Clinical pharmacokinetics. (1996) [Pubmed]
  5. Opioid inhibition of formalin-induced changes in plasma extravasation and local blood flow in rats. Taylor, B.K., Peterson, M.A., Roderick, R.E., Tate, J., Green, P.G., Levine, J.O., Basbaum, A.I. Pain (2000) [Pubmed]
  6. Effects of pain and audiovisual stimulation on the opioid-induced depression of the hypoxic ventilatory response. Karan, S., Voter, W., Palmer, L., Ward, D.S. Anesthesiology (2005) [Pubmed]
  7. Behavioral and physiological effects of remifentanil and alfentanil in healthy volunteers. Black, M.L., Hill, J.L., Zacny, J.P. Anesthesiology (1999) [Pubmed]
  8. The effect of remifentanil on seizure duration and acute hemodynamic responses to electroconvulsive therapy. Recart, A., Rawal, S., White, P.F., Byerly, S., Thornton, L. Anesth. Analg. (2003) [Pubmed]
  9. A randomized, blind comparison of remifentanil and alfentanil during anesthesia for outpatient surgery. Cartwright, D.P., Kvalsvik, O., Cassuto, J., Jansen, J.P., Wall, C., Remy, B., Knape, J.T., Noronha, D., Upadhyaya, B.K. Anesth. Analg. (1997) [Pubmed]
  10. Remifentanil and coronary artery surgery. Duthie, D.J., Stevens, J.J., Doyle, A.R., Baddoo, H.H. Lancet (1995) [Pubmed]
  11. The influence of nitrous oxide and remifentanil on cerebral hemodynamics in conscious human volunteers. Lorenz, I.H., Kolbitsch, C., Hörmann, C., Luger, T.J., Schocke, M., Eisner, W., Moser, P.L., Schubert, H., Kremser, C., Benzer, A. Neuroimage (2002) [Pubmed]
  12. Influence of arteriovenous sampling on remifentanil pharmacokinetics and pharmacodynamics. Hermann, D.J., Egan, T.D., Muir, K.T. Clin. Pharmacol. Ther. (1999) [Pubmed]
  13. Experience with remifentanil in neonates and infants. Welzing, L., Roth, B. Drugs (2006) [Pubmed]
  14. Remifentanil : a review of its analgesic and sedative use in the intensive care unit. Battershill, A.J., Keating, G.M. Drugs (2006) [Pubmed]
  15. A comparison of remifentanil and morphine sulfate for acute postoperative analgesia after total intravenous anesthesia with remifentanil and propofol. Yarmush, J., D'Angelo, R., Kirkhart, B., O'Leary, C., Pitts, M.C., Graf, G., Sebel, P., Watkins, W.D., Miguel, R., Streisand, J., Maysick, L.K., Vujic, D. Anesthesiology (1997) [Pubmed]
  16. Influence of hemorrhagic shock on remifentanil: a pharmacokinetic and pharmacodynamic analysis. Johnson, K.B., Kern, S.E., Hamber, E.A., McJames, S.W., Kohnstamm, K.M., Egan, T.D. Anesthesiology (2001) [Pubmed]
  17. Determination of the potency of remifentanil compared with alfentanil using ventilatory depression as the measure of opioid effect. Glass, P.S., Iselin-Chaves, I.A., Goodman, D., Delong, E., Hermann, D.J. Anesthesiology (1999) [Pubmed]
  18. Intraoperative remifentanil infusion does not increase postoperative opioid consumption compared with 70% nitrous oxide. Lee, L.H., Irwin, M.G., Lui, S.K. Anesthesiology (2005) [Pubmed]
  19. Dexmedetomidine pharmacodynamics: part I: crossover comparison of the respiratory effects of dexmedetomidine and remifentanil in healthy volunteers. Hsu, Y.W., Cortinez, L.I., Robertson, K.M., Keifer, J.C., Sum-Ping, S.T., Moretti, E.W., Young, C.C., Wright, D.R., Macleod, D.B., Somma, J. Anesthesiology (2004) [Pubmed]
  20. Pharmacokinetics of opioids in liver disease. Tegeder, I., Lötsch, J., Geisslinger, G. Clinical pharmacokinetics. (1999) [Pubmed]
  21. Anesthetic potency of remifentanil in dogs. Michelsen, L.G., Salmenperä, M., Hug, C.C., Szlam, F., VanderMeer, D. Anesthesiology (1996) [Pubmed]
  22. Effects of remifentanil, a new short-acting opioid, on cerebral blood flow, brain electrical activity, and intracranial pressure in dogs anesthetized with isoflurane and nitrous oxide. Hoffman, W.E., Cunningham, F., James, M.K., Baughman, V.L., Albrecht, R.F. Anesthesiology (1993) [Pubmed]
  23. Remifentanil induces systemic arterial vasodilation in humans with a total artificial heart. Ouattara, A., Boccara, G., Köckler, U., Lecomte, P., Leprince, P., Léger, P., Riou, B., Rama, A., Coriat, P. Anesthesiology (2004) [Pubmed]
  24. The comparative pharmacodynamics of remifentanil and its metabolite, GR90291, in a rat electroencephalographic model. Cox, E.H., Langemeijer, M.W., Gubbens-Stibbe, J.M., Muir, K.T., Danhof, M. Anesthesiology (1999) [Pubmed]
  25. Effects of propofol and remifentanil on phrenic nerve activity and nociceptive cardiovascular responses in rabbits. Ma, D., Chakrabarti, M.K., Whitwam, J.G. Anesthesiology (1999) [Pubmed]
  26. Effects of remifentanil on N-methyl-D-aspartate receptor: an electrophysiologic study in rat spinal cord. Guntz, E., Dumont, H., Roussel, C., Gall, D., Dufrasne, F., Cuvelier, L., Blum, D., Schiffmann, S.N., Sosnowski, M. Anesthesiology (2005) [Pubmed]
  27. Low-dose remifentanil infusion does not impair natural killer cell function in healthy volunteers. Cronin, A.J., Aucutt-Walter, N.M., Budinetz, T., Bonafide, C.P., DiVittore, N.A., Gordin, V., Schuler, H.G., Bonneau, R.H. British journal of anaesthesia. (2003) [Pubmed]
  28. A rapid increase in the inspired concentration of desflurane is not associated with epileptiform encephalogram. Vakkuri, A.P., Seitsonen, E.R., Jäntti, V.H., Särkelä, M., Korttila, K.T., Paloheimo, M.P., Yli-Hankala, A.M. Anesth. Analg. (2005) [Pubmed]
  29. Comparative abuse liability of intravenously administered remifentanil and fentanyl. Baylon, G.J., Kaplan, H.L., Somer, G., Busto, U.E., Sellers, E.M. Journal of clinical psychopharmacology. (2000) [Pubmed]
  30. Differential contribution of the two phases of the formalin test to the pattern of c-fos expression in the rat spinal cord: studies with remifentanil and lidocaine. Abbadie, C., Taylor, B.K., Peterson, M.A., Basbaum, A.I. Pain (1997) [Pubmed]
  31. Determination of the pharmacodynamic interaction of propofol and remifentanil during esophagogastroduodenoscopy in children. Drover, D.R., Litalien, C., Wellis, V., Shafer, S.L., Hammer, G.B. Anesthesiology (2004) [Pubmed]
  32. Comparative pharmacokinetics and pharmacodynamics of remifentanil, its principle metabolite (GR90291) and alfentanil in dogs. Hoke, J.F., Cunningham, F., James, M.K., Muir, K.T., Hoffman, W.E. J. Pharmacol. Exp. Ther. (1997) [Pubmed]
  33. Opioid-volatile anesthetic synergy: a response surface model with remifentanil and sevoflurane as prototypes. Manyam, S.C., Gupta, D.K., Johnson, K.B., White, J.L., Pace, N.L., Westenskow, D.R., Egan, T.D. Anesthesiology (2006) [Pubmed]
  34. Population pharmacodynamics and pharmacokinetics of remifentanil as a supplement to nitrous oxide anesthesia for elective abdominal surgery. Drover, D.R., Lemmens, H.J. Anesthesiology (1998) [Pubmed]
  35. The effects of remifentanil on epileptiform discharges during intraoperative electrocorticography in patients undergoing epilepsy surgery. Wass, C.T., Grady, R.E., Fessler, A.J., Cascino, G.D., Lozada, L., Bechtle, P.S., Marsh, W.R., Sharbrough, F.W., Schroeder, D.R. Epilepsia (2001) [Pubmed]
  36. Correlation of approximate entropy, bispectral index, and spectral edge frequency 95 (SEF95) with clinical signs of "anesthetic depth" during coadministration of propofol and remifentanil. Bruhn, J., Bouillon, T.W., Radulescu, L., Hoeft, A., Bertaccini, E., Shafer, S.L. Anesthesiology (2003) [Pubmed]
  37. Remifentanil versus morphine analgesia and sedation for mechanically ventilated critically ill patients: a randomized double blind study. Dahaba, A.A., Grabner, T., Rehak, P.H., List, W.F., Metzler, H. Anesthesiology (2004) [Pubmed]
  38. Dexmedetomidine pharmacodynamics: Part II: Crossover comparison of the analgesic effect of dexmedetomidine and remifentanil in healthy volunteers. Cortinez, L.I., Hsu, Y.W., Sum-Ping, S.T., Young, C., Keifer, J.C., Macleod, D., Robertson, K.M., Wright, D.R., Moretti, E.W., Somma, J. Anesthesiology (2004) [Pubmed]
  39. Combining fMRI with a pharmacokinetic model to determine which brain areas activated by painful stimulation are specifically modulated by remifentanil. Wise, R.G., Rogers, R., Painter, D., Bantick, S., Ploghaus, A., Williams, P., Rapeport, G., Tracey, I. Neuroimage (2002) [Pubmed]
  40. Remifentanil administration reveals biphasic phMRI temporal responses in rat consistent with dynamic receptor regulation. Liu, C.H., Greve, D.N., Dai, G., Marota, J.J., Mandeville, J.B. Neuroimage (2007) [Pubmed]
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