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Gene Review

BP3  -  Blood pressure QTL 3

Homo sapiens

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Disease relevance of BP3

  • The level of BP3 was the most significant factor predictive of breast cancer [1].
  • Regression analyses revealed that AF IGF BP3 was positively associated with birth weight within LGA and macrosomia subpopulations (partial r2 = 0.0283 and 0.0404, respectively) [2].
  • Systemic levels contribute significantly to increased intraocular IGF-I, IGF-II and IGF-BP3 [correction of IFG-BP3] in proliferative diabetic retinopathy [3].
  • The aim of the study was to investigate endogenous growth hormone (GH) secretion in patients with osteoporosis and in patients with degenerative bone diseases or no spinal disease by measuring serum insulin-like growth factors 1 and 2 (IGFs) and their major binding protein 3 (BP-3) as an indirect parameter of GH secretion [4].

High impact information on BP3

  • Construction of an approximately 4 Mb YAC contig of this region identified multiple sequence tagged sites (STSs) present at both BP2 and BP3, suggestive of a genomic duplication event [5].
  • Three independent clonal lines were obtained that secreted IgG HumAbs, including one IgG1 kappa (BP3) and two distinct IgG4 kappa (BP1 and BP2) [6].
  • We investigated whether the three sunscreens benzophenone-3 (BP-3), octyl-methoxycinnamate (OMC), and 3-(4-methylbenzylidene) camphor (4-MBC) were absorbed and influenced endogenous reproductive hormone levels in humans after topical application [7].
  • The method was then applied to the detection of different mutations, in the presence of wild type, of a 276 bp fragment of the insulin-like growth factor 1-binding protein 1 (IGF1-BP3) gene [8].
  • 4) Human recombinant glycosylated [125I]BP-3 when added to cultured Sertoli cells was preserved in the medium when IGF-I or analogs with BP-3 affinity were present [9].

Biological context of BP3


Anatomical context of BP3


Associations of BP3 with chemical compounds


Other interactions of BP3


Analytical, diagnostic and therapeutic context of BP3


  1. Altered serum levels of insulin-like growth-factor binding proteins in breast cancer patients. Ng, E.H., Ji, C.Y., Tan, P.H., Lin, V., Soo, K.C., Lee, K.O. Ann. Surg. Oncol. (1998) [Pubmed]
  2. Insulin-like growth factor II and binding proteins 1 and 3 from second trimester human amniotic fluid are associated with infant birth weight. Tisi, D.K., Liu, X.J., Wykes, L.J., Skinner, C.D., Koski, K.G. J. Nutr. (2005) [Pubmed]
  3. Systemic levels contribute significantly to increased intraocular IGF-I, IGF-II and IGF-BP3 [correction of IFG-BP3] in proliferative diabetic retinopathy. Spranger, J., Bühnen, J., Jansen, V., Krieg, M., Meyer-Schwickerath, R., Blum, W.F., Schatz, H., Pfeiffer, A.F. Horm. Metab. Res. (2000) [Pubmed]
  4. Decreased serum levels of insulin-like growth factors and IGF binding protein 3 in osteoporosis. Wüster, C., Blum, W.F., Schlemilch, S., Ranke, M.B., Ziegler, R. J. Intern. Med. (1993) [Pubmed]
  5. Large genomic duplicons map to sites of instability in the Prader-Willi/Angelman syndrome chromosome region (15q11-q13). Christian, S.L., Fantes, J.A., Mewborn, S.K., Huang, B., Ledbetter, D.H. Hum. Mol. Genet. (1999) [Pubmed]
  6. Human monoclonal autoantibodies specific for the bullous pemphigoid antigen 1 (BPAg 1). Peyron, E., Nicolas, J.F., Réano, A., Roche, P., Thivolet, J., Haftek, M., Schmitt, D., Péronne, C., Banchereau, J., Rousset, F. J. Immunol. (1994) [Pubmed]
  7. Systemic absorption of the sunscreens benzophenone-3, octyl-methoxycinnamate, and 3-(4-methyl-benzylidene) camphor after whole-body topical application and reproductive hormone levels in humans. Janjua, N.R., Mogensen, B., Andersson, A.M., Petersen, J.H., Henriksen, M., Skakkebaek, N.E., Wulf, H.C. J. Invest. Dermatol. (2004) [Pubmed]
  8. Single strand conformational polymorphism using capillary electrophoresis with two-dye laser-induced fluorescence detection. Hebenbrock, K., Williams, P.M., Karger, B.L. Electrophoresis (1995) [Pubmed]
  9. Mechanisms of Sertoli cell insulin-like growth factor (IGF)-binding protein-3 regulation by IGF-I and adenosine 3',5'-monophosphate. Smith, E.P., Cheung, P.T., Ferguson, A., Chernausek, S.D. Endocrinology (1992) [Pubmed]
  10. Human chromosome 15q11-q14 regions of rearrangements contain clusters of LCR15 duplicons. Pujana, M.A., Nadal, M., Guitart, M., Armengol, L., Gratacòs, M., Estivill, X. Eur. J. Hum. Genet. (2002) [Pubmed]
  11. One year growth hormone replacement therapy does not alter colonic epithelial cell proliferation in growth hormone deficient adults. Beentjes, J.A., van Gorkom, B.A., Sluiter, W.J., de Vries, E.G., Kleibeuker, J.H., Dullaart, R.P. Clin. Endocrinol. (Oxf) (2000) [Pubmed]
  12. Angelman syndrome associated with oculocutaneous albinism due to an intragenic deletion of the P gene. Fridman, C., Hosomi, N., Varela, M.C., Souza, A.H., Fukai, K., Koiffmann, C.P. Am. J. Med. Genet. A (2003) [Pubmed]
  13. Expression of IGF-II and IGF-binding proteins by colon cancer cells in relation to growth response to IGFs. Singh, P., Dai, B., Yallampalli, C., Xu, Z. Am. J. Physiol. (1994) [Pubmed]
  14. A new model using liposomes that allow to distinguish between absorption and oxidative properties of sunscreens. Tran, C., Sorg, O., Carraux, P., Didierjean, L., Siegenthaler, G., Falson, F., Saurat, J.H. Photochem. Photobiol. (2002) [Pubmed]
  15. Expression of osteoblast marker genes in rat calvarial osteoblast-like cells, and effects of the endocrine disrupters diphenylolpropane, benzophenone-3, resveratrol and silymarin. Ziolkowska, A., Rucinski, M., Pucher, A., Tortorella, C., Nussdorfer, G.G., Malendowicz, L.K. Chem. Biol. Interact. (2006) [Pubmed]
  16. Estradiol and resveratrol stimulating effect on osteocalcin, but not osteonectin and collagen-1alpha gene expression in primary culture of rat calvarial osteoblast-like cells. Rucinski, M., Ziolkowska, A., Hochol, A., Pucher, A., Macchi, C., Belloni, A.S., Nussdorfer, G.G., Malendowicz, L.K. Int. J. Mol. Med. (2006) [Pubmed]
  17. Endocrine disruptors and rat adrenocortical function: Studies on freshly dispersed and cultured cells. Ziolkowska, A., Belloni, A.S., Nussdorfer, G.G., Nowak, M., Malendowicz, L.K. Int. J. Mol. Med. (2006) [Pubmed]
  18. Localisation and regulation of the eIF4E-binding protein 4E-BP3. Kleijn, M., Scheper, G.C., Wilson, M.L., Tee, A.R., Proud, C.G. FEBS Lett. (2002) [Pubmed]
  19. Influence of angiotensin-converting enzyme polymorphism gene, IGF-1, and other factors in the response rate of hematocrit to enalapril treatment in patients with posttransplant erythrocytosis. Jimeno, L., Rodado, R., Barrios, Y., Campos, M., Llorente, S., Nicolas, F., Minguela, A. Transplant. Proc. (2005) [Pubmed]
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