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MeSH Review

Rats, Inbred BUF

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Disease relevance of Rats, Inbred BUF


High impact information on Rats, Inbred BUF


Biological context of Rats, Inbred BUF


Anatomical context of Rats, Inbred BUF

  • Since our studies, and those of others, have relied on the genetic purity of inbred Buffalo rats, we chose to test these animals for expression of strain-dependent, allotype-specific variants of CD45 (leukocyte common antigen, LCA) using the monoclonal antibodies RT7.1 and RT7 [9].
  • In contrast, untreated F-344 rats exhibited higher levels of DHA binding in hypothalamus and SPD binding in striatum than BUF rats [10].

Associations of Rats, Inbred BUF with chemical compounds


Gene context of Rats, Inbred BUF

  • Inbred LEW, COP, WKY, F344, and BUF rats immunized with BII reacted strongest with CB9-7 and variably with CB11 and CB12 [15].
  • Although Crabp2 had been identified as one of the 16 genes differentially expressed between ACI and BUF rats with cDNA-RDA, Fabp1 and Ugt2b5 were newly identified in this study [16].
  • The two strains differed qualitatively in the effect of morphine on striatal SPD binding, with BUF rats exhibiting a decrease, and F-344 rats an increase [10].
  • Immunization with R16 also induced low levels of inflammation in eyes of 75% and 20% of LEJ and BUF rats, respectively, but this peptide did not cause any disease in SDJ and TO rats [17].


  1. Anti-idiotypic immunity and autoimmunity. I. In vitro and in vivo effects of anti-idiotypic antibodies to spontaneously occurring autoantibodies to rat thyroglobulin. Zanetti, M., Bigazzi, P.E. Eur. J. Immunol. (1981) [Pubmed]
  2. Whole-genome analyses of loss of heterozygosity and methylation analysis of four tumor-suppressor genes in N-methyl-N'-nitro-N-nitrosoguanidine-induced rat stomach carcinomas. Niwa, T., Yamashita, S., Tsukamoto, T., Kuramoto, T., Nomoto, T., Wakazono, K., Fujita, H., Matsushima, T., Tatematsu, M., Sugimura, T., Ushijima, T. Cancer Sci. (2005) [Pubmed]
  3. Strain differences in rat brain epinephrine synthesis: regulation of alpha-adrenergic receptor number by epinephrine. Perry, B.D., Stolk, J.M., Vantini, G., Guchhait, R.B., U'Prichard, D.C. Science (1983) [Pubmed]
  4. Sequential histologic changes during gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in susceptible ACI and resistant BUF rats. Ohgaki, H., Kusama, K., Hasegawa, H., Sato, S., Takayama, S., Sugimura, T. J. Natl. Cancer Inst. (1986) [Pubmed]
  5. Dietary effects of menhaden oil on the growth and membrane lipid composition of rat mammary tumors. Jurkowski, J.J., Cave, W.T. J. Natl. Cancer Inst. (1985) [Pubmed]
  6. Age-dependent growth inhibition of estrogen-sensitive rat mammary tumors. Probable role of alpha-fetoprotein. Sonnenschein, C., Ucci, A.A., Soto, A.M. J. Natl. Cancer Inst. (1980) [Pubmed]
  7. Growth inhibition of estrogen-sensitive rat mammary tumors. Effect of an alpha-fetoprotein-secreting hepatoma. Sonnenschein, C., Ucci, A.A., Soto, A.M. J. Natl. Cancer Inst. (1980) [Pubmed]
  8. Profiling and selection of genes differentially expressed in the pylorus of rat strains with different proliferative responses and stomach cancer susceptibility. Yamashita, S., Wakazono, K., Sugimura, T., Ushijima, T. Carcinogenesis (2002) [Pubmed]
  9. Evidence for genetic contamination of inbred buffalo rats (RT-1b) obtained from a commercial vendor. Jones, R.E., Weinberg, A., Bourdette, D. J. Neuroimmunol. (1994) [Pubmed]
  10. Comparison of regional CNS ligand binding in two inbred rat strains: effects of chronic morphine. Cooper, D.O., Carlson, K.R., McKearney, J.W. Pharmacol. Biochem. Behav. (1985) [Pubmed]
  11. Effects of dietary lipids on lactogenic hormone receptor binding in rat mammary tumors. Cave, W.T., Erickson-Lucas, M.J. J. Natl. Cancer Inst. (1982) [Pubmed]
  12. Histopathology of breast lesions induced in BUF rats of varying ages by ingestion of N-4-(4'-fluorobiphenyl) acetamide. Stromberg, K., Reuber, M.D. J. Natl. Cancer Inst. (1975) [Pubmed]
  13. Effects of cyanate, thiocyanate, and amygdalin on metabolite uptake in normal and neoplastic tissues of the rat. Lea, M.A., Koch, M.R. J. Natl. Cancer Inst. (1979) [Pubmed]
  14. Both bone marrow- and non-bone marrow-associated factors determine susceptibility to experimental autoimmune encephalomyelitis of BUF and WAG rats. van Gelder, M., Kinwel-Bohré, E.P., Mulder, A.H., van Bekkum, D.W. Cell. Immunol. (1996) [Pubmed]
  15. Collagen-induced arthritis in rats. Examination of the epitope specificities of circulating and cartilage-bound antibodies produced by outbred and inbred rats using cyanogen bromide-derived peptides purified from heterologous and homologous type II collagens. Cremer, M.A., Terato, K., Watson, W.C., Griffiths, M.M., Townes, A.S., Kang, A.H. J. Immunol. (1992) [Pubmed]
  16. Differential expression of genes related to levels of mucosal cell proliferation among multiple rat strains by using oligonucleotide microarrays. Yamashita, S., Nomoto, T., Ohta, T., Ohki, M., Sugimura, T., Ushijima, T. Mamm. Genome (2003) [Pubmed]
  17. Interphotoreceptor retinoid-binding protein derived peptide can induce experimental autoimmune uveoretinitis in various rat strains. Sasamoto, Y., Kotake, S., Yoshikawa, K., Wiggert, B., Gery, I., Matsuda, H. Curr. Eye Res. (1994) [Pubmed]
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