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Gene Review

Pnmt  -  phenylethanolamine-N-methyltransferase

Rattus norvegicus

Synonyms: Noradrenaline N-methyltransferase, PNMTase, Phenylethanolamine N-methyltransferase
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Disease relevance of Pnmt


High impact information on Pnmt


Chemical compound and disease context of Pnmt


Biological context of Pnmt


Anatomical context of Pnmt


Associations of Pnmt with chemical compounds


Regulatory relationships of Pnmt


Other interactions of Pnmt


Analytical, diagnostic and therapeutic context of Pnmt


  1. Investigation of the phenylethanolamine N-methyltransferase gene as a candidate gene for hypertension. Koike, G., Jacob, H.J., Krieger, J.E., Szpirer, C., Hoehe, M.R., Horiuchi, M., Dzau, V.J. Hypertension (1995) [Pubmed]
  2. Association between the phenylethanolamine N-methyltransferase gene and multiple sclerosis. Mann, M.B., Wu, S., Rostamkhani, M., Tourtellotte, W., MacMurray, J.P., Comings, D.E. J. Neuroimmunol. (2002) [Pubmed]
  3. Effects of insulin treatment without and with recurrent hypoglycemia on hypoglycemic counterregulation and adrenal catecholamine-synthesizing enzymes in diabetic rats. Inouye, K.E., Yue, J.T., Chan, O., Kim, T., Akirav, E.M., Park, E., Riddell, M.C., Burdett, E., Matthews, S.G., Vranic, M. Endocrinology (2006) [Pubmed]
  4. Effects of chronic prenatal hypoxia on tyrosine hydroxylase and phenylethanolamine N-methyltransferase messenger RNA and protein levels in medulla oblongata of postnatal rat. White, L.D., Lawson, E.E. Pediatr. Res. (1997) [Pubmed]
  5. Phenylethanolamine N-methyltransferase (PNMT)-expressing horizontal cells in the rat retina: a study employing double-label immunohistochemistry. Hammang, J.P., Bohn, M.C., Messing, A. J. Comp. Neurol. (1992) [Pubmed]
  6. Impulse activity differentially regulates [Leu]enkephalin and catecholamine characters in the adrenal medulla. LaGamma, E.F., Adler, J.E., Black, I.B. Science (1984) [Pubmed]
  7. Strain differences in rat brain epinephrine synthesis: regulation of alpha-adrenergic receptor number by epinephrine. Perry, B.D., Stolk, J.M., Vantini, G., Guchhait, R.B., U'Prichard, D.C. Science (1983) [Pubmed]
  8. Glucocorticoid induction of epinephrine synthesizing enzyme in rat skeletal muscle and insulin resistance. Kennedy, B., Elayan, H., Ziegler, M.G. J. Clin. Invest. (1993) [Pubmed]
  9. Antecedent hypoglycemia, catecholamine depletion, and subsequent sympathetic neural responses. Herlein, J.A., Morgan, D.A., Phillips, B.G., Haynes, W.G., Sivitz, W.I. Endocrinology (2006) [Pubmed]
  10. Involvement of epinephrine in the presynaptic beta adrenoceptor mechanism of norepinephrine release from rat hypothalamic slices. Ueda, H., Goshima, Y., Kubo, T., Misu, Y. J. Pharmacol. Exp. Ther. (1985) [Pubmed]
  11. Evidence for a sodium-induced activation of central neurogenic mechanisms in one-kidney, one-clip renal hypertensive rats. Waeber, B., Gavras, H., Gavras, I., Chao, P., Kohlman, O., Bresnahan, M.R., Brunner, H.R., Vaughan, D. J. Pharmacol. Exp. Ther. (1982) [Pubmed]
  12. PNMT-containing neurons in the rostral medulla oblongata (C1, C3 groups) are transneuronally labelled after injection of herpes simplex virus type 1 into the adrenal gland. Wesselingh, S.L., Li, Y.W., Blessing, W.W. Neurosci. Lett. (1989) [Pubmed]
  13. Homodimerization of the glucocorticoid receptor is not essential for response element binding: activation of the phenylethanolamine N-methyltransferase gene by dimerization-defective mutants. Adams, M., Meijer, O.C., Wang, J., Bhargava, A., Pearce, D. Mol. Endocrinol. (2003) [Pubmed]
  14. Regulation of the rat phenylethanolamine N-methyltransferase gene by transcription factors Sp1 and MAZ. Her, S., Claycomb, R., Tai, T.C., Wong, D.L. Mol. Pharmacol. (2003) [Pubmed]
  15. Dual immunocytochemistry using 125I-labeled protein A: a new electron microscopic technique applied to the investigation of chemical connectivity and axonal transmitter co-localization in the brain. Kachidian, P., Bosler, O. J. Neurosci. Methods (1991) [Pubmed]
  16. Morphometrical and microdensitometrical studies on phenylethanolamine-N-methyltransferase- and neuropeptide Y-immunoreactive neurons in the rostral medulla oblongata of the adult and old male rat. Agnati, L.F., Fuxe, K., Zoli, M., Zini, I., Härfstrand, A., Toffano, G., Goldstein, M. Neuroscience (1988) [Pubmed]
  17. Effects of antibodies against acetylcholinesterase on the expression of peptides and catecholamine synthesizing enzymes in the rat adrenal gland. Dagerlind, A., Brimijoin, S., Goldstein, M., Hökfelt, T. Neuroscience (1993) [Pubmed]
  18. Morphometrical and microdensitometrical studies on phenylethanolamine-N-methyltransferase- and neuropeptide Y-immunoreactive nerve terminals and on glucocorticoid receptor-immunoreactive nerve cell nuclei in the paraventricular hypothalamic nucleus in adult and old male rats. Zoli, M., Agnati, L.F., Fuxe, K., Zini, I., Merlo Pich, E., Grimaldi, R., Härfstrand, A., Goldstein, M., Wikström, A.C., Gustafsson, J.A. Neuroscience (1988) [Pubmed]
  19. Effect of haemorrhage on the expression of neurotransmitter-related genes in rat ventrolateral medulla: a quantitative real-time RT-PCR study. Li, Q., Goodchild, A.K., Pilowsky, P.M. Brain Res. Mol. Brain Res. (2003) [Pubmed]
  20. Expression of phenylethanolamine N-methyltransferase (PNMT) and neuropeptide Y (NPY) in embryonic rat medulla oblongata grown in Oculo. Bohn, M.C., Seiger, A., Bernstein-Goral, H. J. Chem. Neuroanat. (1988) [Pubmed]
  21. Expression of catecholamine-synthesizing enzymes, peptidylglycine alpha-amidating monooxygenase, and neuropeptide Y mRNA in the rat adrenal medulla after acute systemic nicotine. Jahng, J.W., Houpt, T.A., Joh, T.H., Wessel, T.C. J. Mol. Neurosci. (1997) [Pubmed]
  22. Existence of cardiac PNMT mRNA in adult rats: elevation by stress in a glucocorticoid-dependent manner. Krizanová, O., Micutková, L., Jeloková, J., Filipenko, M., Sabban, E., Kvetnanský, R. Am. J. Physiol. Heart Circ. Physiol. (2001) [Pubmed]
  23. Neuropeptide Y-like immunoreactivity in adrenaline cells of adrenal medulla and in tumors and plasma of pheochromocytoma patients. Lundberg, J.M., Hökfelt, T., Hemsén, A., Theodorsson-Norheim, E., Pernow, J., Hamberger, B., Goldstein, M. Regul. Pept. (1986) [Pubmed]
  24. Cholinergic and peptidergic regulation of phenylethanolamine N-methyltransferase gene expression. Wong, D.L., Anderson, L.J., Tai, T.C. Ann. N. Y. Acad. Sci. (2002) [Pubmed]
  25. Role of transcription factor Egr-1 in phorbol ester-induced phenylethanolamine N-methyltransferase gene expression. Morita, K., Ebert, S.N., Wong, D.L. J. Biol. Chem. (1995) [Pubmed]
  26. Evidence for discrete alterations in central cardiovascular catecholamine and neuropeptide Y immunoreactive neurons in aged male rats and in genetically hypertensive male rats of the Lyon strain. Fuxe, K., Agnati, L.F., Kitayama, I., Zoli, M., Janson, A.M., Härfstrand, A., Vincent, M., Kalia, M., Goldstein, M., Sassard, J. Eur. Heart J. (1987) [Pubmed]
  27. Adrenomedullin receptor is found exclusively in noradrenaline-secreting cells of the rat adrenal medulla. Renshaw, D., Thomson, L.M., Michael, G.J., Carroll, M., Kapas, S., Hinson, J.P. J. Neurochem. (2000) [Pubmed]
  28. Immunocytochemical localization of tyrosine hydroxylase, dopamine-beta-hydroxylase and phenylethanolamine-N-methyltransferase in the adrenal glands of the frog and rat by a peroxidase-antiperoxidase method. Nagatsu, I., Karasawa, N., Kondo, Y., Inagaki, S. Histochemistry (1979) [Pubmed]
  29. Differential activation of the rat phenylethanolamine N-methyltransferase gene by Sp1 and Egr-1. Ebert, S.N., Wong, D.L. J. Biol. Chem. (1995) [Pubmed]
  30. Effects of adrenal medulla grafts on memory capacities of rats after hippocampal lesions. Jousselin-Hosaja, M., Collery, M., Delacour, J. Neuroscience (1994) [Pubmed]
  31. Stress increases gene expression of phenylethanolamine N-methyltransferase in spleen of rats via pituitary-adrenocortical mechanism. Jelokova, J., Rusnak, M., Kubovcakova, L., Buckendahl, P., Krizanova, O., Sabban, E.L., Kvetnansky, R. Psychoneuroendocrinology (2002) [Pubmed]
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