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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Chondroma


High impact information on Chondroma


Chemical compound and disease context of Chondroma


Biological context of Chondroma

  • The expression of the two catalytic subunits of protein phosphatase (PP) type 1 PP1 gamma 1 and PP1 delta was examined in 4 cases of osteochondroma and 4 cases of enchondroma as a benign cartilaginous tumor, and 4 cases of chondrosarcoma as a malignant cartilaginous tumor using immunohistochemical analysis [15].

Anatomical context of Chondroma


Gene context of Chondroma


Analytical, diagnostic and therapeutic context of Chondroma

  • STUDY DESIGN/MATERIALS AND METHODS: Fourteen enchondromas, in eight patients, involving the tubular bones of the hand, were treated with curettage, CO2 laser sterilization of the tumor margins followed by autologous bone grafting [11].
  • To further characterize chondrogenic tumors and to determine whether PTHrP and the regulation of Bcl-2-expression is of relevance to tumorigenesis, we analyzed the expression of both PTHrP and Bcl-2 on a series of 23 cases of solitary enchondroma (9 cases) and primary CS (14 cases) using light and confocal microscopy [26].


  1. MYC amplification and polysomy 8 in chondrosarcoma: array comparative genomic hybridization, fluorescent in situ hybridization, and association with outcome. Morrison, C., Radmacher, M., Mohammed, N., Suster, D., Auer, H., Jones, S., Riggenbach, J., Kelbick, N., Bos, G., Mayerson, J. J. Clin. Oncol. (2005) [Pubmed]
  2. Gastric autonomic nerve (GAN) tumor and extra-adrenal paraganglioma in Carney's triad. A common origin. Tortella, B.J., Matthews, J.B., Antonioli, D.A., Dvorak, A.M., Silen, W. Ann. Surg. (1987) [Pubmed]
  3. Pulmonary metastatic leiomyosarcoma coexisting with pulmonary chondroma in Carney's triad. Chahinian, A.P., Kirschner, P.A., Dikman, S.H., Rammos, K.S., Holland, J.F. Arch. Intern. Med. (1983) [Pubmed]
  4. Tumor-induced osteomalacia: clinical and basic studies. Shane, E., Parisien, M., Henderson, J.E., Dempster, D.W., Feldman, F., Hardy, M.A., Tohme, J.F., Karaplis, A.C., Clemens, T.L. J. Bone Miner. Res. (1997) [Pubmed]
  5. Carney triad: case report and molecular analysis of gastric tumor. Diment, J., Tamborini, E., Casali, P., Gronchi, A., Carney, J.A., Colecchia, M. Hum. Pathol. (2005) [Pubmed]
  6. Absence of IHH and retention of PTHrP signalling in enchondromas and central chondrosarcomas. Rozeman, L.B., Hameetman, L., Cleton-Jansen, A.M., Taminiau, A.H., Hogendoorn, P.C., Bovée, J.V. J. Pathol. (2005) [Pubmed]
  7. Molecular analysis of the INK4A/INK4A-ARF gene locus in conventional (central) chondrosarcomas and enchondromas: indication of an important gene for tumour progression. van Beerendonk, H.M., Rozeman, L.B., Taminiau, A.H., Sciot, R., Bovée, J.V., Cleton-Jansen, A.M., Hogendoorn, P.C. J. Pathol. (2004) [Pubmed]
  8. A distinct phenotype characterizes tumors from a putative genetic trait involving chondrosarcoma and breast cancer occurring in the same patient. Cleton-Jansen, A.M., Timmerman, M.C., van de Vijver, M.J., van Asperen, C.J., Kroon, H.M., Eilers, P.H., Hogendoorn, P.C. Lab. Invest. (2004) [Pubmed]
  9. Cyclooxygenase-2 expression in chondrosarcoma. Sutton, K.M., Wright, M., Fondren, G., Towle, C.A., Mankin, H.J. Oncology (2004) [Pubmed]
  10. Deposition of calcium pyrophosphate dihydrate crystals in a soft tissue chondroma. Athanasou, N.A., Caughey, M., Burge, P., Woods, C.G. Ann. Rheum. Dis. (1991) [Pubmed]
  11. Adjunctive treatment of enchondromas with CO2 laser. Giles, D.W., Miller, S.J., Rayan, G.M. Lasers in surgery and medicine. (1999) [Pubmed]
  12. Maffucci's syndrome--the result of neural abnormalities? Evidence of mitogenic neurotransmitters present in enchondromas and soft tissue hemangiomas. Robinson, D., Tieder, M., Halperin, N., Burshtein, D., Nevo, Z. Cancer (1994) [Pubmed]
  13. Intraosseous calcifications in tophaceous gout. Resnick, D., Broderick, T.W. AJR. American journal of roentgenology. (1981) [Pubmed]
  14. Avulsion of flexor profundus, secondary to enchondroma of the distal phalanx. Ogunro, O. The Journal of hand surgery. (1983) [Pubmed]
  15. Selective increase in expression of isoform PP1 gamma 1 of type-1 protein phosphatase in chondrosarcoma cells. Sogawa, K., Yamada, T., Funamoto, Y., Kohno, K., Nishikawa, H., Kishida, F., Hamazaki, F., Yamashita, N., Matsumoto, K. Res. Commun. Mol. Pathol. Pharmacol. (1994) [Pubmed]
  16. Transoral-transpharyngeal approach to the anterior craniocervical junction. Ten-year experience with 72 patients. Menezes, A.H., VanGilder, J.C. J. Neurosurg. (1988) [Pubmed]
  17. Avulsion of the flexor digitorum profundus tendon associated with a chondroma of the distal phalanx. Canovas, F., Nicolau, F., Bonnel, F. Journal of hand surgery (Edinburgh, Lothian) (1998) [Pubmed]
  18. Proteoglycans and chondroitin sulfates from human multiple chondroma (enchondromatosis). Michelacci, Y.M., Laredo, J., Dietrich, C.P. Braz. J. Med. Biol. Res. (1981) [Pubmed]
  19. Immunohistochemical study on collagenous proteins and biophysical analysis of crystals in extraskeletal chondroma. Ota, M., Oda, Y., Nakanishi, I. Pathol. Int. (1995) [Pubmed]
  20. Giant cell reparative granuloma in the hand: report of three cases and review of the literature. Merkow, R.L., Bansal, M., Inglis, A.E. The Journal of hand surgery. (1985) [Pubmed]
  21. Enchondromatosis (Ollier disease, Maffucci syndrome) is not caused by the PTHR1 mutation p.R150C. Rozeman, L.B., Sangiorgi, L., Briaire-de Bruijn, I.H., Mainil-Varlet, P., Bertoni, F., Cleton-Jansen, A.M., Hogendoorn, P.C., Bovée, J.V. Hum. Mutat. (2004) [Pubmed]
  22. Fusion, disruption, and expression of HMGA2 in bone and soft tissue chondromas. Dahlén, A., Mertens, F., Rydholm, A., Brosjö, O., Wejde, J., Mandahl, N., Panagopoulos, I. Mod. Pathol. (2003) [Pubmed]
  23. Differentiation and proliferative activity in benign and malignant cartilage tumors of bone. Hasegawa, T., Seki, K., Yang, P., Hirose, T., Hizawa, K., Wada, T., Wakabayashi, J. Hum. Pathol. (1995) [Pubmed]
  24. Expression of connective tissue growth factor in cartilaginous tumors. Shakunaga, T., Ozaki, T., Ohara, N., Asaumi, K., Doi, T., Nishida, K., Kawai, A., Nakanishi, T., Takigawa, M., Inoue, H. Cancer (2000) [Pubmed]
  25. Developmental pathways in musculoskeletal neoplasia: involvement of the Indian Hedgehog-parathyroid hormone-related protein pathway. Tiet, T.D., Alman, B.A. Pediatr. Res. (2003) [Pubmed]
  26. PTHrP and Bcl-2: essential regulatory molecules in chondrocyte differentiation and chondrogenic tumors. Amling, M., Pösl, M., Hentz, M.W., Priemel, M., Delling, G. Verhandlungen der Deutschen Gesellschaft für Pathologie. (1998) [Pubmed]
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