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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Cranial Fossa, Posterior

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Disease relevance of Cranial Fossa, Posterior


High impact information on Cranial Fossa, Posterior

  • First cytogenetic study of a recurrent familial chordoma of the clivus [6].
  • Infiltration of the clivus by the tumor and LDH greater than 410 U/L are the two independent and useful prognostic factors in patients with locoregionally advanced NPC who were treated with CCRT [7].
  • METHODS: Twenty-one normal children 3 to 11.5 years old underwent computed tomographic examinations from the lower clivus to the base of C3 in various head positions during axial rotation [8].
  • These modifications consisted of a hemisphenoidotomy, a partial ethmoidectomy, extended sellar floor opening toward the planum sphenoidale or the clivus, enlarged opening of the sphenoid ostium area with ipsilateral removal of the superior turbinate, and a bilateral approach [9].
  • Radiologically, there was fusion of C1, C2, and the clivus [10].

Chemical compound and disease context of Cranial Fossa, Posterior


Anatomical context of Cranial Fossa, Posterior

  • This report describes in a stepwise fashion the surgical anatomy of an approach to the midline and lateral compartments of the skull base (clivus, infralabyrinthine/infratemporal regions) [14].
  • After removal of the clivus with a drill, the vertebral and basilar arteries are exposed through a midline dural opening [15].
  • The authors report on 16 consecutive patients requiring exposure from clivus through C3 for pathology, including spinal cord compression by rheumatoid pannus, craniovertebral anomalies, and tumor [16].
  • The author suggests that a rupture is initiated by the compression of the brain stem against the clivus, whereby the pedunculi are displaced away from each other, and that the rupture naturally continues along the midline vessels to end in the aqueduct [17].
  • Gadolinium diethylene-thiamine-pentaacetic acid enhanced T1-weighted magnetic resonance (MR) images showed a homogeneously enhanced mass lesion involving the lower clivus and the foramen magnum [18].

Associations of Cranial Fossa, Posterior with chemical compounds

  • We retrospectively reviewed 330 T1-weighted sagittal images, 80 T2-weighted sagittal images, and 83 gadopentetate-dimeglumine-enhanced scans of normal adults to determine the MR appearance of the normal adult clivus [19].
  • Similarly, the ability to localize the rostral limit of the clivus that needed to be resected and the caudal extent of C2 that needed to be removed to achieve an adequate decompression helped ensure that the extent of bone removal was appropriately tailored to the patient's anatomy [20].
  • Magnetic resonance imaging showed gadolinium enhancement of the soft tissue overlying the clivus and around the odontoid, impinging on the medulla and high cervical cord [21].
  • The position offers a view that is approximately coronal to the clivus and tentorium [22].
  • This case shows that polyglactin 910 mesh may be ineffective when used for posterior cranial fossa duraplasty in children, although it is considered as valuable as autologous tissue [11].

Gene context of Cranial Fossa, Posterior

  • Transoral resection of the dens, the anterior arch of C-1, and the lower clivus does not fully destabilize the spine; however, this operation may potentiate incipient pathological instability [23].
  • Clivus chordoma in a child with tuberous sclerosis: CT and MR demonstration [24].
  • Primary neoplasms, metastatic tumors, and inflammatory, vascular, and hematopoietic disorders are the most common abnormalities to arise from or directly involve the clivus [25].
  • After the first operation, local recurrence and CSF dissemination to the lower clivus occurred within two months [26].
  • Axial computerized tomography (CT) scans revealed a C-1 ring fracture, basilar invagination with the dens abutting the clivus, and significant lateral splaying of the C-1 lateral masses [27].

Analytical, diagnostic and therapeutic context of Cranial Fossa, Posterior


  1. Myasthenia gravis in a man with a history of chordoma: observations of muscle-like antigens in carcinoma. Carson, H.J., Streib, E.W. Hum. Pathol. (1993) [Pubmed]
  2. A modified transfacial approach to the clivus. Swearingen, B., Joseph, M., Cheney, M., Ojemann, R.G. Neurosurgery (1995) [Pubmed]
  3. Syringomyelia as a postoperative sequela of the resection of a chordoma of the clivus: case report. Lovely, T.J., Buchheit, W.A. Neurosurgery (1991) [Pubmed]
  4. Drop metastases in a patient with a chondroid chordoma of the clivus. Uggowitzer, M.M., Kugler, C., Groell, R., Lindbichler, F., Radner, H., Sutter, B., Ranner, G. Neuroradiology. (1999) [Pubmed]
  5. Posterior cranial fossa dermoid in association with craniovertebral and cervical spinal anomaly: report of two cases. Muzumdar, D., Goel, A. Pediatric neurosurgery. (2001) [Pubmed]
  6. First cytogenetic study of a recurrent familial chordoma of the clivus. Dalprà, L., Malgara, R., Miozzo, M., Riva, P., Volonte, M., Larizza, L., Fuhrman Conti, A.M. Int. J. Cancer (1999) [Pubmed]
  7. Prognostic features and treatment outcome in locoregionally advanced nasopharyngeal carcinoma following concurrent chemotherapy and radiotherapy. Cheng, S.H., Jian, J.J., Tsai, S.Y., Chan, K.Y., Yen, L.K., Chu, N.M., Tan, T.D., Tsou, M.H., Huang, A.T. Int. J. Radiat. Oncol. Biol. Phys. (1998) [Pubmed]
  8. Atlantoaxial rotatory fixation: Part 1--Biomechanics of normal rotation at the atlantoaxial joint in children. Pang, D., Li, V. Neurosurgery (2004) [Pubmed]
  9. Endoscopic transsphenoidal approach: adaptability of the procedure to different sellar lesions. de Divitiis, E., Cappabianca, P., Cavallo, L.M. Neurosurgery (2002) [Pubmed]
  10. Odontoid process and C1-C2 corrective osteotomy through a posterior approach: technical case report. Grundy, P.L., Gill, S.S. Neurosurgery (1998) [Pubmed]
  11. Cerebrospinal fluid seepage through polyglactin 910 dura substitute manifested as spinal extradural collection of fluid. Stancić, M.F., Nozica, E., Penezić, L. Croat. Med. J. (2000) [Pubmed]
  12. Clinical use of lidocaine for control of stroke oedema in the posterior cranial fossa accompanied by acute hydrocephalus. Hirayama, A., Yamasaki, S., Miyata, M. Acta Neurochir. Suppl. (2000) [Pubmed]
  13. Endoscopic approach to lesions of the sphenoid sinus, orbital apex, and clivus. Kingdom, T.T., Delgaudio, J.M. American journal of otolaryngology. (2003) [Pubmed]
  14. The mandibular swing-transcervical approach to the skull base: anatomical study. Technical note. Ammirati, M., Ma, J., Cheatham, M.L., Mei, Z.T., Bloch, J., Becker, D.P. J. Neurosurg. (1993) [Pubmed]
  15. Transfacial transclival approach for midline posterior circulation aneurysms. Ogilvy, C.S., Barker, F.G., Joseph, M.P., Cheney, M.L., Swearingen, B., Crowell, R.M. Neurosurgery (1996) [Pubmed]
  16. Transoral approach to the upper cervical spine. Merwin, G.E., Post, J.C., Sypert, G.W. Laryngoscope (1991) [Pubmed]
  17. Midline rupture of the mesencephalon. Bojsen-Møller, M. Acta neurochirurgica. Supplementum. (1983) [Pubmed]
  18. End-to-end anastomosis of the posterior inferior cerebellar artery before excision of a meningioma involving the lower clivus and the foramen magnum. Case report. Touho, H. Surgical neurology. (1999) [Pubmed]
  19. MR imaging of the normal and abnormal clivus. Kimura, F., Kim, K.S., Friedman, H., Russell, E.J., Breit, R. AJNR. American journal of neuroradiology. (1990) [Pubmed]
  20. Frameless stereotactic guidance. An intraoperative adjunct in the transoral approach for ventral cervicomedullary junction decompression. Pollack, I.F., Welch, W., Jacobs, G.B., Janecka, I.P. Spine. (1995) [Pubmed]
  21. Painful torticollis with tongue atrophy--a different neck-tongue syndrome. O'Meara, M., Wise, G. Neuropediatrics. (1995) [Pubmed]
  22. The clival-perpendicular or modified Water's view in compound tomography. Fitz, C.R., Harwood-Nash, D.C., Resjo, M., Chuang, S. Neuroradiology. (1978) [Pubmed]
  23. The influence of transoral odontoid resection on stability of the craniovertebral junction. Dickman, C.A., Locantro, J., Fessler, R.G. J. Neurosurg. (1992) [Pubmed]
  24. Clivus chordoma in a child with tuberous sclerosis: CT and MR demonstration. Schroeder, B.A., Wells, R.G., Starshak, R.J., Sty, J.R. Journal of computer assisted tomography. (1987) [Pubmed]
  25. MR imaging of clival and paraclival lesions. Chaljub, G., Van Fleet, R., Guinto, F.C., Crow, W.N., Martinez, L., Kumar, R. AJR. American journal of roentgenology. (1992) [Pubmed]
  26. Intracranial adenoid cystic carcinoma of suprasellar region. Tsuyuguchi, N., Ohata, K., Goto, T., Haque, M., Hara, M. Acta neurochirurgica. (2001) [Pubmed]
  27. Novel treatment of basilar invagination resulting from an untreated C-1 fracture associated with transverse ligament avulsion. Case report and description of surgical technique. Ames, C.P., Acosta, F., Nottmeier, E. Journal of neurosurgery. Spine. (2005) [Pubmed]
  28. A new transfacial approach for lesions of the clivus and parapharyngeal space: the partial segmented Le Fort I osteotomy. Diaz-Gonzalez, F.J., Padrón, A., Foncea, A.M., García de Sola, R., Naval, L., Rubio, P. Plast. Reconstr. Surg. (1999) [Pubmed]
  29. T classification and clivus margin as risk factors for determining locoregional control by radiotherapy of nasopharyngeal carcinoma. Jian, J.J., Cheng, S.H., Prosnitz, L.R., Tsai, S.Y., Tsai, M.J., Huang, A.T. Cancer (1998) [Pubmed]
  30. Decisive role of immunocytochemistry in aspiration cytology of chordoma of the clivus: a case report with review of the literature. Gherardi, G., Marveggio, C., Cola, C., Redaelli, G. The Journal of laryngology and otology. (1994) [Pubmed]
  31. Indium111 pentetreotide single photon emission computed tomography (In111 pentetreotide SPECT): a new technique to evaluate somatostatin receptors in chordomas. Di Girolamo, S., Ottaviani, F., Floris, R., Bruno, E., Napolitano, B., Schillaci, O. The Journal of laryngology and otology. (2005) [Pubmed]
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