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MeSH Review

Chorda Tympani Nerve

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Disease relevance of Chorda Tympani Nerve

  • Nineteen patients aged 5 to 9 years, with excessive drooling as a result of perinatal brain damage, have been treated surgically at Groote Schuur Hospital, Cape Town, by bilateral tympanic neurectomies, unilateral chorda tympani nerve section and contralateral submandibular gland excision [1].

High impact information on Chorda Tympani Nerve

  • Restriction of maternal dietary sodium on or before embryonic day 8 reduced taste responses of the chorda tympani nerve to sodium chloride in the offspring [2].
  • We have discovered that the gerbil's chorda tympani nerve response to sucrose is suppressed by p-nitrophenyl alpha-D-glucopyranoside (PNP-Glu) and chloramphenicol (CAP) [3].
  • In contrast, many chorda tympani nerve branches were observed near the epithelial surface in mice overexpressing BDNF, and most were attracted to and invaded non-taste filiform papillae instead of gustatory papillae [4].
  • Chorda tympani nerve branching was reduced in NT4 overexpressing mice, and neuronal fibers in these mice were fasciculated and remained below the epithelial surface, as if repelled by NT4 overexpression [4].
  • The effects of changed ionic environments on the canine taste responses to sugars were examined by recording the activity of the chorda tympani nerve. a) The responses to various sugars were greatly enhanced by the presence of salts having monovalent cations such as Na+, K+, choline+, or Tris+ [5].

Biological context of Chorda Tympani Nerve


Anatomical context of Chorda Tympani Nerve


Associations of Chorda Tympani Nerve with chemical compounds

  • Accordingly, our results suggest that some chronic factors, including high blood glucose, inefficiency of insulin action, or leptin resistance may be related to the enhancement of chorda tympani nerve responses to sugars [12].
  • The rate of inactivation can be measured by monitoring the decay of NaCl-stimulated summated electrophysiological activity at the chorda tympani nerve in the presence of NEM [13].
  • High-fat diet-induced obese rats and streptozotocin-diabetic rats also showed greater chorda tympani nerve responses to sugars as was observed in VMH-lesioned obese rats, indicating that VMH lesions might not be specifically related to the enhanced gustatory neural responses to sugars [12].
  • Recording of the chorda tympani nerve showed good responses by saccharin, quinine, and denatonium at concentrations of 1 mM and higher [14].
  • Stimulation of bitterness by capsaicin and menthol: differences between lingual areas innervated by the glossopharyngeal and chorda tympani nerves [15].

Gene context of Chorda Tympani Nerve


Analytical, diagnostic and therapeutic context of Chorda Tympani Nerve


  1. Surgery of sialorrhoea. Sellars, S.L. The Journal of laryngology and otology. (1985) [Pubmed]
  2. Influences of dietary sodium on functional taste receptor development: a sensitive period. Hill, D.L., Przekop, P.R. Science (1988) [Pubmed]
  3. Antagonism of the gerbil's sucrose taste response by p-nitrophenyl alpha-D-glucopyranoside and chloramphenicol. Vlahopoulos, V., Jakinovich, W. J. Neurosci. (1986) [Pubmed]
  4. Epithelial overexpression of BDNF and NT4 produces distinct gustatory axon morphologies that disrupt initial targeting. Lopez, G.F., Krimm, R.F. Dev. Biol. (2006) [Pubmed]
  5. Large enhancement of canine taste responses to sugars by salts. Kumazawa, T., Kurihara, K. J. Gen. Physiol. (1990) [Pubmed]
  6. Sympathetic mediation of salivation induced by intracerebroventricular pilocarpine in rats. Cecanho, R., Anaya, M., Renzi, A., Menani, J.V., De Luca, L.A. J. Auton. Nerv. Syst. (1999) [Pubmed]
  7. Lipopolysaccharide-induced elevation and secretion of interleukin-1beta in the submandibular gland of male mice. Yao, C., Li, X., Murdiastuti, K., Kosugi-Tanaka, C., Akamatsu, T., Kanamori, N., Hosoi, K. Immunology (2005) [Pubmed]
  8. Effect of salivation on neural taste responses in freely moving rats: analyses of salivary secretion and taste responses of the chorda tympani nerve. Matsuo, R., Yamamoto, T., Ikehara, A., Nakamura, O. Brain Res. (1994) [Pubmed]
  9. The effect of clonidine on centrally and peripherally evoked submaxillary salivation. Green, G.J., Wilson, H., Yates, M.S. Eur. J. Pharmacol. (1979) [Pubmed]
  10. Association of extracellular acetylcholinesterase with gustatory nerve terminal fibers in the nucleus of the solitary tract. Barry, M.A., Haglund, S., Savoy, L.D. Brain Res. (2001) [Pubmed]
  11. The role of the chorda tympani nerve in the activation of the rat hypothalamic histaminergic system by leptin. Morimoto-Ishizuka, T., Yamamoto, Y., Yamatodani, A. Neurosci. Lett. (2001) [Pubmed]
  12. Enhanced responses of the chorda tympani nerve to sugars in the ventromedial hypothalamic obese rat. Shimizu, Y., Yamazaki, M., Nakanishi, K., Sakurai, M., Sanada, A., Takewaki, T., Tonosaki, K. J. Neurophysiol. (2003) [Pubmed]
  13. N-substituted maleimide inactivation of the response to taste cell stimulation. Mooser, G. J. Neurobiol. (1976) [Pubmed]
  14. Transduction for sweet taste of saccharin may involve both inositol 1,4,5-trisphosphate and cAMP pathways in the fungiform taste buds in C57BL mice. Nakashima, K., Ninomiya, Y. Cell. Physiol. Biochem. (1999) [Pubmed]
  15. Stimulation of bitterness by capsaicin and menthol: differences between lingual areas innervated by the glossopharyngeal and chorda tympani nerves. Green, B.G., Schullery, M.T. Chem. Senses (2003) [Pubmed]
  16. Enhancement of murine gustatory neural responses to D-amino acids by saccharin. Ninomiya, Y., Kajiura, H. Brain Res. (1993) [Pubmed]
  17. Recovery of Salt Taste Responses and PGP 9.5 Immunoreactive Taste Bud Cells during Regeneration of the Mouse Chorda Tympani Nerve. Yasumatsu, K., Shigemura, N., Yoshida, R., Ninomiya, Y. Chem. Senses (2005) [Pubmed]
  18. Vasoactive intestinal peptide and substance P in salivary glands of the rat following denervation or duct ligation. Ekström, J., Brodin, E., Ekman, R., Håkanson, R., Sundler, F. Regul. Pept. (1984) [Pubmed]
  19. Acute anosmia in the mouse: behavioral discrimination among the four basic taste substances. Uebayashi, H., Hatanaka, T., Kanemura, F., Tonosaki, K. Physiol. Behav. (2001) [Pubmed]
  20. The role of tissue mast cells in exocrine secretion: studies in the submandibular gland of the cat. Erjavec, F., Logonder-Mlinsek, M., Ozvald, R., Stanovnik, L. Agents Actions (1983) [Pubmed]
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