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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Hallux


Psychiatry related information on Hallux


High impact information on Hallux

  • A similar somatotopic representation pattern between fingers and the hallux was also observed within ipsilateral SII, indicating somatotopy of contra- as well as ipsilateral SII using unilateral stimulation [7].
  • RESEARCH DESIGN AND METHODS: VPTs were measured using a handheld biothesiometer at the medial malleolus and hallux in 232 nondiabetic children and adolescents aged 7-18 years (12.9 +/- 4.2 years) and a population-based sample of 307 young IDDM patients (13.3 +/- 4.6 years of age) [8].
  • Classical SCS associated with a TWIST 1 mutation could be separated phenotypically from the Muenke phenotype on the basis of the following features: low-set frontal hairline, gross ptosis of eyelids, subnormal ear length, dilated parietal foramina, interdigital webbing, and hallux valgus or broad great toe with bifid distal phalanx [9].
  • Toe pressure of the hallux (TP1) and second toe (TP2) and transcutaneous oxygen pressure (TCPO2) measurements are becoming more important [10].
  • Although not exclusive to rheumatoid arthritis, hallux valgus must have been caused for the most part by the rheumatoid arthritis and if so, then it is suggested that the provision of suitable shoes for patients may be less costly than subsequent surgical treatment [11].

Chemical compound and disease context of Hallux

  • This article presents a case of entrapment of the flexor hallucis longus tendon after open reduction and internal fixation of a Weber C ankle fracture resulting in interphalangeal joint contracture of the hallux [12].

Biological context of Hallux


Anatomical context of Hallux


Associations of Hallux with chemical compounds

  • In the ChloraPrep group, bacteria grew on culture of specimens from 30% of the hallux sites, 23% of the toe sites, and 10% of the control sites [19].
  • We conclude that adding 1 microg/kg clonidine to 0.75% ropivacaine provided a 3-h delay in first request for pain medication after hallux valgus repair, with no clinically relevant side effects [20].
  • Manipulation of the metatarsophalangeal joint and injection with steroid and local anaesthetic are widely practised in the treatment of hallux rigidus, but there is little information on the outcome [21].
  • Microscopic metallic wear and tissue response in failed titanium hallux metatarsophalangeal implants: two cases [22].
  • The final position of the hallux metatarsal is influenced by the coronal plane orientation of the saw [23].

Gene context of Hallux

  • Fibrodysplasia ossificans progressiva in children can often be recognized at birth because of the presence of shortening of the great toe, characteristic hallux valgus, and short thumbs [24].
  • A 6-camera 60 Hz video-based motion analysis system was used to measure motion of the shank, rearfoot, forefoot, and hallux segments and the vertical displacement of the navicular [25].
  • We prospectively reviewed 24 patients (35 feet) who had been treated by a Scarf osteotomy and Akin closing-wedge osteotomy for hallux valgus between June 2000 and June 2002 [26].
  • Structure was dominant in predicting peak pressure under the midfoot and MTH1, while both structure and function were important at the heel and hallux [27].
  • This study presents a synopsis of the senior author's (LCS) experience with 439 surgically treated patients with hallux metatarsophalangeal arthritis, focusing on origin and treatment [28].

Analytical, diagnostic and therapeutic context of Hallux


  1. Long-term results of the modified Hoffman procedure in the rheumatoid forefoot. Surgical technique. Thomas, S., Kinninmonth, A.W., Kumar, C.S. The Journal of bone and joint surgery. American volume. (2006) [Pubmed]
  2. Microphthalmia, facial anomalies, microcephaly, thumb and hallux hypoplasia, and agammaglobulinemia. Verloes, A., Dresse, M.F., Keutgen, H., Asplund, C., Smith, C.I. Am. J. Med. Genet. (2001) [Pubmed]
  3. Arthroplasty of the first metatarsophalangeal joint with a double-stem silicone implant. Results in patients who have degenerative joint disease failure of previous operations, or rheumatoid arthritis. Cracchiolo, A., Weltmer, J.B., Lian, G., Dalseth, T., Dorey, F. The Journal of bone and joint surgery. American volume. (1992) [Pubmed]
  4. Machado-Joseph shoe. Liu, C.S., Hsieh, M., Chen, Y.Y., Lo, M.C. Mov. Disord. (2005) [Pubmed]
  5. Pigmented villonodular synovitis of the MTP joint of the hallux. Michael, A.L., Chelliah, G., Ali, H., Thomas, A.P. Scand. J. Rheumatol. (2003) [Pubmed]
  6. Array comparative genomic hybridization analysis of a familial duplication of chromosome 13q: a recognizable syndrome. Mathijssen, I.B., Hoovers, J.M., Mul, A.N., Man, H.Y., Ket, J.L., Hennekam, R.C. Am. J. Med. Genet. A (2005) [Pubmed]
  7. Somatotopic organization of human secondary somatosensory cortex. Ruben, J., Schwiemann, J., Deuchert, M., Meyer, R., Krause, T., Curio, G., Villringer, K., Kurth, R., Villringer, A. Cereb. Cortex (2001) [Pubmed]
  8. The use of biothesiometry to detect neuropathy in children and adolescents with IDDM. Davis, E.A., Jones, T.W., Walsh, P., Byrne, G.C. Diabetes Care (1997) [Pubmed]
  9. Saethre-Chotzen syndrome caused by TWIST 1 gene mutations: functional differentiation from Muenke coronal synostosis syndrome. Kress, W., Schropp, C., Lieb, G., Petersen, B., Büsse-Ratzka, M., Kunz, J., Reinhart, E., Schäfer, W.D., Sold, J., Hoppe, F., Pahnke, J., Trusen, A., Sörensen, N., Krauss, J., Collmann, H. Eur. J. Hum. Genet. (2006) [Pubmed]
  10. Interobserver and intraobserver reproducibility of peripheral blood and oxygen pressure measurements in the assessment of lower extremity arterial disease. de Graaff, J.C., Ubbink, D.T., Legemate, D.A., de Haan, R.J., Jacobs, M.J. J. Vasc. Surg. (2001) [Pubmed]
  11. The foot in chronic rheumatoid arthritis. Vidigal, E., Jacoby, R.K., Dixon, A.S., Ratliff, A.H., Kirkup, J. Ann. Rheum. Dis. (1975) [Pubmed]
  12. Hallux flexion deformity secondary to entrapment of the flexor hallucis longus tendon after fibular fracture. Leitschuh, P.H., Zimmerman, J.P., Uhorchak, J.M., Arciero, R.A., Bowser, L. Foot & ankle international / American Orthopaedic Foot and Ankle Society [and] Swiss Foot and Ankle Society. (1995) [Pubmed]
  13. The diagnosis of onychomycosis in a geriatric population: a study of 450 cases in South Florida. Scherer, W.P., McCreary, J.P., Hayes, W.W. Journal of the American Podiatric Medical Association. (2001) [Pubmed]
  14. Dorsal bunions in children. McKay, D.W. The Journal of bone and joint surgery. American volume. (1983) [Pubmed]
  15. Arthrodesis of the first metatarsophalangeal joint for hallux valgus in rheumatoid arthritis. Mann, R.A., Thompson, F.M. The Journal of bone and joint surgery. American volume. (1984) [Pubmed]
  16. A double-blinded, randomized comparison of either 0.5% levobupivacaine or 0.5% ropivacaine for sciatic nerve block. Casati, A., Borghi, B., Fanelli, G., Cerchierini, E., Santorsola, R., Sassoli, V., Grispigni, C., Torri, G. Anesth. Analg. (2002) [Pubmed]
  17. A comparison of results from two mycology laboratories for the diagnosis of onychomycosis: a study of 85 cases in a geriatric population. Scherer, W.P., Scherer, M.D. Journal of the American Podiatric Medical Association. (2004) [Pubmed]
  18. The radiographic morphology of foot deformities in patients with fibrodysplasia ossificans progressiva. Harrison, R.J., Pitcher, J.D., Mizel, M.S., Temple, H.T., Scully, S.P. Foot & ankle international / American Orthopaedic Foot and Ankle Society [and] Swiss Foot and Ankle Society. (2005) [Pubmed]
  19. Efficacy of surgical preparation solutions in foot and ankle surgery. Ostrander, R.V., Botte, M.J., Brage, M.E. The Journal of bone and joint surgery. American volume. (2005) [Pubmed]
  20. Small-dose clonidine prolongs postoperative analgesia after sciatic-femoral nerve block with 0.75% ropivacaine for foot surgery. Casati, A., Magistris, L., Fanelli, G., Beccaria, P., Cappelleri, G., Aldegheri, G., Torri, G. Anesth. Analg. (2000) [Pubmed]
  21. Manipulation and injection for hallux rigidus. Is it worthwhile? Solan, M.C., Calder, J.D., Bendall, S.P. The Journal of bone and joint surgery. British volume. (2001) [Pubmed]
  22. Microscopic metallic wear and tissue response in failed titanium hallux metatarsophalangeal implants: two cases. Ghalambor, N., Cho, D.R., Goldring, S.R., Nihal, A., Trepman, E. Foot & ankle international / American Orthopaedic Foot and Ankle Society [and] Swiss Foot and Ankle Society. (2002) [Pubmed]
  23. Proximal crescentic metatarsal osteotomy: the effect of saw blade orientation on first ray elevation. Jones, C., Coughlin, M., Villadot, R., Golanó, P. Foot & ankle international / American Orthopaedic Foot and Ankle Society [and] Swiss Foot and Ankle Society. (2005) [Pubmed]
  24. Fibrodysplasia ossificans progressiva. A survey of forty-two cases. Rogers, J.G., Geho, W.B. The Journal of bone and joint surgery. American volume. (1979) [Pubmed]
  25. Multisegment foot motion during gait: proof of concept in rheumatoid arthritis. Woodburn, J., Nelson, K.M., Siegel, K.L., Kepple, T.M., Gerber, L.H. J. Rheumatol. (2004) [Pubmed]
  26. Scarf osteotomy for hallux valgus. A prospective clinical and pedobarographic study. Jones, S., Al Hussainy, H.A., Ali, F., Betts, R.P., Flowers, M.J. The Journal of bone and joint surgery. British volume. (2004) [Pubmed]
  27. Structural and functional predictors of regional peak pressures under the foot during walking. Morag, E., Cavanagh, P.R. Journal of biomechanics. (1999) [Pubmed]
  28. Hallux metatarsophalangeal arthritis. Weinfeld, S.B., Schon, L.C. Clin. Orthop. Relat. Res. (1998) [Pubmed]
  29. Levobupivacaine 0.2% or 0.125% for continuous sciatic nerve block: a prospective, randomized, double-blind comparison with 0.2% ropivacaine. Casati, A., Vinciguerra, F., Cappelleri, G., Aldegheri, G., Grispigni, C., Putzu, M., Rivoltini, P. Anesth. Analg. (2004) [Pubmed]
  30. Periarticular injuries to the hallux metatarsophalangeal joint in athletes. Watson, T.S., Anderson, R.B., Davis, W.H. Foot and ankle clinics. (2000) [Pubmed]
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