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Chemical Compound Review

AC1NSEO7     (1E)-2-[6-[[amino-[[amino- [(4...

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Disease relevance of


High impact information on

  • The order of transfection efficacy was dimyristyl (di-C14:0) > dioleyl (di-C18:1) > dipalmityl (di-C16:0) > disteryl (di-C18:0) [6].
  • In the ChloraPrep group, bacteria grew on culture of specimens from 30% of the hallux sites, 23% of the toe sites, and 10% of the control sites [7].
  • The other group (control) used a 10 ml 0.2% CHX (=20 mg) mouthrinse on an 11.8% ethanol alcohol base (Corsodyl), CHX plus sign in circleAlc), twice daily for 60 s [8].
  • In the first study, the skin compatibility of Sterillium, a liquid alcoholic rub-in hand disinfectant was compared with that of Hibiscrub, a water-based handwashing antiseptic [9].
  • MRSA was found to be significantly less susceptible than MSSA to chlorhexidine digluconate, 'Hibiscrub' and 'Hibisol' (P < 0.05; two-tailed t-test for independent samples). 'Hibisol' was significantly more effective against MRSA than 'Hibiscrub' (P < 0.05) [10].

Chemical compound and disease context of


Biological context of


Anatomical context of

  • Monocytes were sampled from the peripheral blood of healthy adults, stained with fluorescein isothiocyanate (FITC)-labeled antihuman monoclonal antibodies, and sorted by an FCM, which had been sterilized with 0.5% Hibitane alcohol solution [15].
  • It was found that Hibitane (0.2--2%) caused a significant amelioration of inflamed palatal tissues and a reduction in the number of yeast cells harbored on the palatal mucosa and the fitting surface of the dentures [14].
  • Sixty-eight sows were matched according to their parity and week of mating and divided into 2 groups: treatment sows (CVS) had their vulva cleaned with a 1:2000 Hibitane solution and control sows (SVS) had theirs soiled with feces [16].
  • Alcoholic chlorhexidine solutions and Hibiscrub were the only preparations that gave significant, mean reductions (97.9-99.9% and 80.3-93.4%, respectively) in the number of colony forming units [17].
  • The HeLa cells showed the best recovery after having been influenced by Jodopax, Chloramine-T or sodium hypochlorite solutions, whereas the best tissue recovery was observed in the experiments with Biosept and Hibitane [18].

Associations of with other chemical compounds


Gene context of


Analytical, diagnostic and therapeutic context of


  1. Chlorhexidine resistance in methicillin-resistant Staphylococcus aureus or just an elevated MIC? An in vitro and in vivo assessment. Cookson, B.D., Bolton, M.C., Platt, J.H. Antimicrob. Agents Chemother. (1991) [Pubmed]
  2. Peritonitis in peritoneal dialysis: bacterial colonization by biofilm spread along the catheter surface. Read, R.R., Eberwein, P., Dasgupta, M.K., Grant, S.K., Lam, K., Nickel, J.C., Costerton, J.W. Kidney Int. (1989) [Pubmed]
  3. A clinical trial to assess the efficacy of sanguinarine-zinc mouthrinse (Veadent) compared with chlorhexidine mouthrinse (Corsodyl). Moran, J., Addy, M., Newcombe, R. Journal of clinical periodontology. (1988) [Pubmed]
  4. Outlook for Hibitane in dental caries. Emilson, C.G. Journal of clinical periodontology. (1977) [Pubmed]
  5. Hibitane in periodontal disease. Gjermo, P. Journal of clinical periodontology. (1977) [Pubmed]
  6. Enhanced gene delivery and mechanism studies with a novel series of cationic lipid formulations. Felgner, J.H., Kumar, R., Sridhar, C.N., Wheeler, C.J., Tsai, Y.J., Border, R., Ramsey, P., Martin, M., Felgner, P.L. J. Biol. Chem. (1994) [Pubmed]
  7. Efficacy of surgical preparation solutions in foot and ankle surgery. Ostrander, R.V., Botte, M.J., Brage, M.E. The Journal of bone and joint surgery. American volume. (2005) [Pubmed]
  8. Plaque inhibition of two commercially available chlorhexidine mouthrinses. Van Strydonck, D.A., Timmerman, M.F., van der Velden, U., van der Weijden, G.A. Journal of clinical periodontology. (2005) [Pubmed]
  9. Hand antiseptics: rubs versus scrubs, alcoholic solutions versus alcoholic gels. Pietsch, H. J. Hosp. Infect. (2001) [Pubmed]
  10. Limited effectiveness of chlorhexidine based hand disinfectants against methicillin-resistant Staphylococcus aureus (MRSA). Kampf, G., Jarosch, R., Rüden, H. J. Hosp. Infect. (1998) [Pubmed]
  11. Inactivation of a rotavirus by disinfectants. Tan, J.A., Schnagl, R.D. Med. J. Aust. (1981) [Pubmed]
  12. Safety and efficacy of the antiseptic chlorhexidine gluconate. Rosenberg, A., Alatary, S.D., Peterson, A.F. Surgery, gynecology & obstetrics. (1976) [Pubmed]
  13. Assessment of coronal leakage in teeth root filled with gutta-percha and a glass of ionomer root canal sealer. Tidswell, H.E., Saunders, E.M., Saunders, W.P. International endodontic journal. (1994) [Pubmed]
  14. Hibitane in the treatment of oral candidiasis. Budtz-Jörgensen, E. Journal of clinical periodontology. (1977) [Pubmed]
  15. Sterile sorting of Leu-11a-positive cells (NK cells) using flow cytometry and the antineoplastic effects on brain tumors. Fujiwara, H., Kawamoto, K., Numa, Y., Matsumura, H. Life Sci. (1989) [Pubmed]
  16. Influence of vulvar hygiene on cytology of vaginal smears after sham artificial insemination in sows. Carabin, H., Desnoyers, M., Vaillancourt, D., Martineau, G.P. Can. J. Vet. Res. (1995) [Pubmed]
  17. Comparative antibacterial effectiveness of seven hand antiseptics. Myklebust, S. Scandinavian journal of dental research. (1985) [Pubmed]
  18. Biological evaluation of root canal antiseptics using in vitro and in vivo methods. Wennberg, A. Scandinavian journal of dental research. (1980) [Pubmed]
  19. Evaluation of the optimal hand-scrub duration prior to total hip arthroplasty. O'Farrell, D.A., Kenny, G., O'Sullivan, M., Nicholson, P., Stephens, M., Hone, R. J. Hosp. Infect. (1994) [Pubmed]
  20. Correlation between the in vivo and in vitro antimicrobial properties of commercially available mouthwash preparations. Moneib, N.A., el-Said, M.A., Shibl, A.M. Journal of chemotherapy (Florence, Italy) (1992) [Pubmed]
  21. Influence of a single application of subgingival chlorhexidine gel or tetracycline paste on the clinical parameters of adult periodontitis patients. Unsal, E., Akkaya, M., Walsh, T.F. Journal of clinical periodontology. (1994) [Pubmed]
  22. The permeability of dental gloves following exposure to certain dental materials. Tinsley, D., Chadwick, R.G. Journal of dentistry. (1997) [Pubmed]
  23. Total body bathing with 'Hibiscrub' (chlorhexidine) in surgical patients: a controlled trial. Leigh, D.A., Stronge, J.L., Marriner, J., Sedgwick, J. J. Hosp. Infect. (1983) [Pubmed]
  24. Two-dimensional crystallization of bovine rhodopsin. Dratz, E.A., Van Breemen, J.F., Kamps, K.M., Keegstra, W., Van Bruggen, E.F. Biochim. Biophys. Acta (1985) [Pubmed]
  25. Effect of different mouthrinses on Knoop hardness of a restorative composite. Cavalcanti, A.N., Mitsui, F.H., Ambrosano, G.M., Mathias, P., Marchi, G.M. American journal of dentistry. (2005) [Pubmed]
  26. The effects of a 0.12% chlorhexidine-digluconate-containing mouthrinse versus a placebo on plaque and gingival inflammation over a 3-month period. A multicentre study carried out in general dental practices. Eaton, K.A., Rimini, F.M., Zak, E., Brookman, D.J., Hopkins, L.M., Cannell, P.J., Yates, L.G., Morrice, C.A., Lall, B.A., Newman, H.N. Journal of clinical periodontology. (1997) [Pubmed]
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