Disease relevance of Encephalomalacia

• By this technique evidence for the presence of low levels of CMV and EBV genes was detected in most brain specimens from encephalitis patients and in several brain specimens from patients without encephalitis (eg, cortical dysplasia, gliosis, or encephalomalacia) who also had intractable epilepsy [1].
• A very rare case of acute pancreatitis with concurrent encephalomalacia and ascites mimicking hepatic coma is described [2].
• Repin, a major constituent in extracts of the plant Centaurea repens is thought to be the active principal responsible for the development of equine nigropallidal encephalomalacia (ENE), a fatal Parkinson-like neurodegenerative disorder in horses [3].
• When inoculated intracerebrally into suckling mice they caused encephalomalacia, necrosis, meningoencephalitis, congestion, haemorrhage and a granulomatous reaction in the central nervous tissue, hydrocephalus and nervous signs [4].
• Two cases of radiographically isodense subdural hematoma are presented in which absence of displacement of midline cerebral structures was due not to bilateral lesions, but rather to "balancing" of the volumetric effect of a unilateral lesion by preexisting encephalomalacia [5].

High impact information on Encephalomalacia

• Other etiologies of TLE such as a tumor, vascular malformation, encephalomalacia, or congenital developmental abnormality account for about 30% of all patients who undergo epilepsy surgery [6].
• This case report describes onset in utero of multicystic encephalomalacia and microcephaly in a surviving twin whose brain appeared normal on ultrasound scanning before death of the cotwin at 21 weeks' gestation [7].
• Effects of vitamin E and aspirin on the incidence of encephalomalacia, fatty acid status and serum thromboxane levels in chicks [8].
• This study was initiated to examine the role of prostanoids (thromboxane) in the development of nutritional encephalomalacia (NE) [8].
• Preventive effect of selenium, methionine and antioxidants against encephalomalacia of chicks induced by dilauryl succinate [9].

Chemical compound and disease context of Encephalomalacia

• No significant difference in vitamin E deficiency symptoms except incidence of encephalomalacia was observed between the chicks given DLS and UFA [10].
• Supplementation of selenium and methionine with or without simultaneous supplementation of a low level of dl-alpha-tocopheryl acetate had little effect on preventing encephalomalacia [9].
• The protective effect of supplemental selenium, methionine, ascorbic acid, menaquinone and five antioxidants against encephalomalacia of chicks fed a diet containing dilauryl succinate was examined [9].
• Lipoxygenase and other enzymes of arachidonic acid metabolism in the brain of chicks affected by nutritional encephalomalacia [11].
• Vitamin E deficiency and linoleic acid-feeding lead to nutritional encephalomalacia (NE) in chicks, affecting the cerebellum exclusively [12].

Anatomical context of Encephalomalacia

• Diauryl succinate induces vitamin E deficiency signs such as fragility of the erythrocytes and encephalomalacia [9].
• All four patients developed microcephaly, and one patient had encephalomalacia in the distribution of the right anterior and middle cerebral arteries [13].
• For males with elevated serum prolactin even when associated with focal encephalomalacia and seizure disorder, bromocriptine therapy can offer safe benefits including improved semen parameters and normal serum testosterone levels [14].

Gene context of Encephalomalacia

• Cerebral atrophy and cystic encephalomalacia were observed with neuroradiologic imaging and were noted in all 3 postmortem reports of isolated sulfite oxidase deficiency [15].
• Resection of frontal encephalomalacias for intractable epilepsy: outcome and prognostic factors [16].
• Multiple cystic encephalomalacia causes irregular cavities in both hemispheres which often enlarge causing shift of midline structures and increase in head size [17].
• Major etiologic factors leading to infarction, encephalomalacia, leukomalacia, included trauma, hvpoxicischemic encephalopathy (HIE), systemic lupus erythematosus (SLE), encephalitis, vasculitis, venous thrombosis, vasculopathies, and heart problems (22 cases) [18].

References