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MeSH Review

Longitudinal Ligaments

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Disease relevance of Longitudinal Ligaments


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Chemical compound and disease context of Longitudinal Ligaments


Biological context of Longitudinal Ligaments


Anatomical context of Longitudinal Ligaments


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Gene context of Longitudinal Ligaments


Analytical, diagnostic and therapeutic context of Longitudinal Ligaments


  1. Tissue-nonspecific alkaline phosphatase and plasma cell membrane glycoprotein-1 are central antagonistic regulators of bone mineralization. Hessle, L., Johnson, K.A., Anderson, H.C., Narisawa, S., Sali, A., Goding, J.W., Terkeltaub, R., Millan, J.L. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  2. Functional impact of human collagen alpha2(XI) gene polymorphism in pathogenesis of ossification of the posterior longitudinal ligament of the spine. Maeda, S., Ishidou, Y., Koga, H., Taketomi, E., Ikari, K., Komiya, S., Takeda, J., Sakou, T., Inoue, I. J. Bone Miner. Res. (2001) [Pubmed]
  3. Ossification of the thoracic posterior longitudinal ligament in a fixed population. Radiological and neurological manifestations. Ono, M., Russell, W.J., Kudo, S., Kuroiwa, Y., Takamori, M., Motomura, S., Murakami, J. Radiology. (1982) [Pubmed]
  4. Association of the human NPPS gene with ossification of the posterior longitudinal ligament of the spine (OPLL). Nakamura, I., Ikegawa, S., Okawa, A., Okuda, S., Koshizuka, Y., Kawaguchi, H., Nakamura, K., Koyama, T., Goto, S., Toguchida, J., Matsushita, M., Ochi, T., Takaoka, K., Nakamura, Y. Hum. Genet. (1999) [Pubmed]
  5. Sequence variations in the collagen IX and XI genes are associated with degenerative lumbar spinal stenosis. Noponen-Hietala, N., Kyllönen, E., Männikkö, M., Ilkko, E., Karppinen, J., Ott, J., Ala-Kokko, L. Ann. Rheum. Dis. (2003) [Pubmed]
  6. Dietary habits and risk of ossification of the posterior longitudinal ligaments of the spine (OPLL); findings from a case-control study in Japan. Okamoto, K., Kobashi, G., Washio, M., Sasaki, S., Yokoyama, T., Miyake, Y., Sakamoto, N., Ohta, K., Inaba, Y., Tanaka, H. J. Bone Miner. Metab. (2004) [Pubmed]
  7. Mutation in Npps in a mouse model of ossification of the posterior longitudinal ligament of the spine. Okawa, A., Nakamura, I., Goto, S., Moriya, H., Nakamura, Y., Ikegawa, S. Nat. Genet. (1998) [Pubmed]
  8. Genetic mapping of ossification of the posterior longitudinal ligament of the spine. Koga, H., Sakou, T., Taketomi, E., Hayashi, K., Numasawa, T., Harata, S., Yone, K., Matsunaga, S., Otterud, B., Inoue, I., Leppert, M. Am. J. Hum. Genet. (1998) [Pubmed]
  9. Homeobox protein MSX2 acts as a molecular defense mechanism for preventing ossification in ligament fibroblasts. Yoshizawa, T., Takizawa, F., Iizawa, F., Ishibashi, O., Kawashima, H., Matsuda, A., Endo, N., Kawashima, H. Mol. Cell. Biol. (2004) [Pubmed]
  10. Bone morphogenetic protein receptors and activin receptors are highly expressed in ossified ligament tissues of patients with ossification of the posterior longitudinal ligament. Yonemori, K., Imamura, T., Ishidou, Y., Okano, T., Matsunaga, S., Yoshida, H., Kato, M., Sampath, T.K., Miyazono, K., ten Dijke, P., Sakou, T. Am. J. Pathol. (1997) [Pubmed]
  11. Ossification of the posterior longitudinal ligament in ankylosing spondylitis. Olivieri, I., Trippi, D., Gemignani, G., Pasero, G., Grazzini, R. Arthritis Rheum. (1988) [Pubmed]
  12. Ossification of the posterior longitudinal ligament, diffuse, idiopathic skeletal hyperostosis, abnormal retinol and retinol binding protein: a familial observation. De Bandt, M., Meyer, O., Fuster, J.M., Kahn, M.F. J. Rheumatol. (1995) [Pubmed]
  13. Internal carotid artery thrombosis after cervical corpectomy. Chozick, B.S., Watson, P., Greenblatt, S.H. Spine. (1994) [Pubmed]
  14. Fracture of the axis after dome-like cervical laminoplasty. Ito, H., Shimizu, A., Miyamoto, T., Tabuchi, C. Archives of orthopaedic and trauma surgery. (1998) [Pubmed]
  15. Cervical cord compression secondary to ossification of the posterior longitudinal ligament. Sasaki, M. The Journal of orthopaedic and sports physical therapy. (2005) [Pubmed]
  16. Potential role of streptozotocin in enhancing ossification of the posterior longitudinal ligament of the cervical spine in the hereditary spinal hyperostotic mouse (twy/twy). Baba, H., Furusawa, N., Fukuda, M., Maezawa, Y., Imura, S., Kawahara, N., Nakahashi, K., Tomita, K. European journal of histochemistry : EJH. (1997) [Pubmed]
  17. Significance of serum levels of type I procollagen peptide and intact osteocalcin and bone mineral density in patients with ossification of the posterior longitudinal ligaments. Matsui, H., Yudoh, K., Tsuji, H. Calcif. Tissue Int. (1996) [Pubmed]
  18. The location of the paths subserving micturition: studies in patients with cervical myelopathy. Sakakibara, R., Hattori, T., Tojo, M., Yamanishi, T., Yasuda, K., Hirayama, K. J. Auton. Nerv. Syst. (1995) [Pubmed]
  19. Gender-specific haplotype association of collagen alpha2 (XI) gene in ossification of the posterior longitudinal ligament of the spine. Maeda, S., Koga, H., Matsunaga, S., Numasawa, T., Ikari, K., Furushima, K., Harata, S., Takeda, J., Sakou, T., Komiya, S., Inoue, I. J. Hum. Genet. (2001) [Pubmed]
  20. Restriction fragment length polymorphism of genes of the alpha 2(XI) collagen, bone morphogenetic protein-2, alkaline phosphatase, and tumor necrosis factor-alpha among patients with ossification of posterior longitudinal ligament and controls from the Japanese population. Koga, H., Hayashi, K., Taketomi, E., Matsunaga, S., Yashiki, S., Fujiyoshi, T., Sonoda, S., Sakou, T. Spine. (1996) [Pubmed]
  21. Genetic analysis of ossification of the posterior longitudinal ligament. Matsunaga, S., Yamaguchi, M., Hayashi, K., Sakou, T. Spine. (1999) [Pubmed]
  22. Effects of bone-seeking hormones on DNA synthesis, cyclic AMP level, and alkaline phosphatase activity in cultured cells from human posterior longitudinal ligament of the spine. Ishida, Y., Kawai, S. J. Bone Miner. Res. (1993) [Pubmed]
  23. Acute cervical cord injury associated with ossification of the posterior longitudinal ligament. Koyanagi, I., Iwasaki, Y., Hida, K., Imamura, H., Fujimoto, S., Akino, M. Neurosurgery (2003) [Pubmed]
  24. Orthotopic ossification of the spinal ligaments of Zucker fatty rats: a possible animal model for ossification of the human posterior longitudinal ligament. Okano, T., Ishidou, Y., Kato, M., Imamura, T., Yonemori, K., Origuchi, N., Matsunaga, S., Yoshida, H., ten Dijke, P., Sakou, T. J. Orthop. Res. (1997) [Pubmed]
  25. Nerve supply to the posterior longitudinal ligament and the intervertebral disc of the rat vertebral column as studied by acetylcholinesterase histochemistry. II. Regional differences in the distribution of the nerve fibres and their origins. Kojima, Y., Maeda, T., Arai, R., Shichikawa, K. J. Anat. (1990) [Pubmed]
  26. Biomechanics of indirect reduction of bone retropulsed into the spinal canal in vertebral fracture. Harrington, R.M., Budorick, T., Hoyt, J., Anderson, P.A., Tencer, A.F. Spine. (1993) [Pubmed]
  27. Anterior atlantoaxial subluxation in a patient with diffuse idiopathic skeletal hyperostosis. Oostveen, J.C., van de Laar, M.A., Tuynman, F.H. J. Rheumatol. (1996) [Pubmed]
  28. Insulin secretory response is positively associated with the extent of ossification of the posterior longitudinal ligament of the spine. Akune, T., Ogata, N., Seichi, A., Ohnishi, I., Nakamura, K., Kawaguchi, H. The Journal of bone and joint surgery. American volume. (2001) [Pubmed]
  29. Ultrastructure of early calcification in cervical ossification of the posterior longitudinal ligament. Kubota, T., Sato, K., Kawano, H., Yamamoto, S., Hirano, A., Hashizume, Y. J. Neurosurg. (1984) [Pubmed]
  30. Tyrosine hydroxylase-immunoreactive nerve fibres in rat posterior longitudinal ligament. Imai, S., Konttinen, Y.T., Tokunaga, Y., Maeda, T., Hukuda, S., Santavirta, S. J. Auton. Nerv. Syst. (1997) [Pubmed]
  31. Hypertrophy of the posterior longitudinal ligament is a prodromal condition to ossification: a cervical myelopathy case report. Kondo, S., Onari, K., Watanabe, K., Hasegawa, T., Toguchi, A., Mihara, H. Spine. (2001) [Pubmed]
  32. Ossification of the posterior longitudinal ligament in three geographically and genetically different populations of ankylosing spondylitis and other spondyloarthropathies. Ramos-Remus, C., Russell, A.S., Gomez-Vargas, A., Hernandez-Chavez, A., Maksymowych, W.P., Gamez-Nava, J.I., Gonzalez-Lopez, L., García-Hernández, A., Meoño-Morales, E., Burgos-Vargas, R., Suarez-Almazor, M.E. Ann. Rheum. Dis. (1998) [Pubmed]
  33. Uniaxial cyclic stretch induces osteogenic differentiation and synthesis of bone morphogenetic proteins of spinal ligament cells derived from patients with ossification of the posterior longitudinal ligaments. Tanno, M., Furukawa, K.I., Ueyama, K., Harata, S., Motomura, S. Bone (2003) [Pubmed]
  34. Bone morphogenetic protein-2 stimulates differentiation of cultured spinal ligament cells from patients with ossification of the posterior longitudinal ligament. Kon, T., Yamazaki, M., Tagawa, M., Goto, S., Terakado, A., Moriya, H., Fujimura, S. Calcif. Tissue Int. (1997) [Pubmed]
  35. Uni-axial cyclic stretch induces Cbfa1 expression in spinal ligament cells derived from patients with ossification of the posterior longitudinal ligament. Iwasaki, K., Furukawa, K.I., Tanno, M., Kusumi, T., Ueyama, K., Tanaka, M., Kudo, H., Toh, S., Harata, S., Motomura, S. Calcif. Tissue Int. (2004) [Pubmed]
  36. Comparison of the results of laminectomy and open-door laminoplasty for cervical spondylotic myeloradiculopathy and ossification of the posterior longitudinal ligament. Nakano, N., Nakano, T., Nakano, K. Spine. (1988) [Pubmed]
  37. Bone mineral density of the radius in patients with ossification of the cervical posterior longitudinal ligament. A longitudinal study. Morio, Y., Yamamoto, K., Kishimoto, H., Hagino, H., Kuranobu, K., Kagawa, T. Spine. (1993) [Pubmed]
  38. Biomechanical evaluation of hydroxyapatite intervertebral graft and anterior cervical plating in a porcine cadaveric model. Takahashi, T., Tominaga, T., Yoshimoto, T., Koshu, K., Yokobori, A.T., Aizawa, Y. Bio-medical materials and engineering. (1997) [Pubmed]
  39. Surgical treatment for ossification of the posterior longitudinal ligament of the cervical spine. Kawano, H., Handa, Y., Ishii, H., Sato, K., Oku, T., Kubota, T. Journal of spinal disorders. (1995) [Pubmed]
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